Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Puneet Bharill"'
Publikováno v:
PLoS Genetics, Vol 5, Iss 4, p e1000452 (2009)
Insulin/IGF-1 signaling (IIS) regulates development and metabolism, and modulates aging, of Caenorhabditis elegans. In nematodes, as in mammals, IIS is understood to operate through a kinase-phosphorylation cascade that inactivates the DAF-16/FOXO tr
Externí odkaz:
https://doaj.org/article/cc0cd0e3937d4baab0688ecd33bf42ca
Autor:
Carsten Merkwirth, Roman U. Müller, Christine Kurschat, Martin Höhne, Christina Ising, Bernhard Schermer, Dontscho Kerjaschki, Francesca Fabretti, Henning Hagmann, Sebastian Brähler, Sibylle Brinkkoetter, Wilhelm Bloch, Christina B. Schroeter, Sybille Koehler, Puneet Bharill, Thomas Benzing, Paul T. Brinkkoetter
Publikováno v:
The American Journal of Pathology. 186:1128-1139
Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the mitochondrial inner membrane. Loss of the stomatin/PHB/flotillin/HflK/C (SPFH) domain containing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46819cfc4ae44488c45a83b19602a3d
https://doi.org/10.1016/j.ajpath.2015.12.018
https://doi.org/10.1016/j.ajpath.2015.12.018
Autor:
Robert J. Shmookler Reis, Jawahar L. Mehta, Abhijit Dandapat, Srinivas Ayyadevara, Sona Mitra, Changping Hu, Magomed Khaidakov, Puneet Bharill
Publikováno v:
Antioxidants & Redox Signaling. 18:481-490
Oxidative stress and inflammation are leading risk factors for age-associated functional declines. We assessed aspirin effects on endogenous oxidative-stress levels, lifespan, and age-related functional declines, in the nematode Caenorhabditis elegan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da0c2c188b583ee00fd51e138a98068
https://doi.org/10.1089/ars.2011.4151
https://doi.org/10.1089/ars.2011.4151
Autor:
Priyanka Kohli, Bernard R. Brooks, Markus M. Rinschen, Marcus Krüger, Xiongwu Wu, Puneet Bharill, Matthäus J. Reinert, Isabel Saez, Martin Höhne, Oliver Kretz, Bernhard Schermer, Roman-Ulrich Müller, Thomas Benzing, Malte P. Bartram, Tobias B. Huber, Sriram Aravamudhan, David Vilchez
Publikováno v:
Rinschen, M M, Bharill, P, Wu, X, Kohli, P, Reinert, M J, Kretz, O, Saez, I, Schermer, B, Höhne, M, Bartram, M P, Aravamudhan, S, Brooks, B R, Vilchez, D, Huber, T B, Müller, R U, Krüger, M & Benzing, T 2016, ' The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes ', Human Molecular Genetics, vol. 25, no. 7, ddw016, pp. 1328-1344 . https://doi.org/10.1093/hmg/ddw016
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4580de14010ac6431363a5f34977dc3a
https://pure.au.dk/portal/da/publications/the-ubiquitin-ligase-ubr4-controls-stability-of-podocinmec2-supercomplexes(7576f44b-d303-4119-b1e2-b45520303e66).html
https://pure.au.dk/portal/da/publications/the-ubiquitin-ligase-ubr4-controls-stability-of-podocinmec2-supercomplexes(7576f44b-d303-4119-b1e2-b45520303e66).html
Autor:
John J. Thaden, Lulu Xu, Piotr Zimniak, Cagdas Tazearslan, Eric R. Siegel, Robert J. Shmookler Reis, Srinivas Ayyadevara, Ramani Alla, Puneet Bharill, Minho Chae, Hoonyong Lee
Publikováno v:
Aging. 3:125-147
Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal. Among such metabolites, only lipoperoxides have the ability to produce free-radical chain reactions. For t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6c23a7a18e4a55b3fa0c414da1309c
https://doi.org/10.18632/aging.100275
https://doi.org/10.18632/aging.100275
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:1075-1083
Long-lived mutants provide unique insights into the genetic factors that limit lifespan in wild-type animals. Most mutants and RNA-interference targets found to extend life, typically by 1.5- to 2.5-fold, were discovered in C. elegans. Several longev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493fd72909fb994bf4215659aec09d43
https://doi.org/10.1016/j.bbagen.2009.05.011
https://doi.org/10.1016/j.bbagen.2009.05.011
Autor:
Sibylle Brinkkötter, Bernhard Schermer, Peter Frommolt, Thomas Benzing, Francesca Fabretti, Roman-Ulrich Müller, Puneet Bharill, Markus M. Rinschen, Volker Burst, Hakam Gharbi
Publikováno v:
Aging cell. 12(4)
Summary Signaling through the hypoxia-inducible factor hif-1 controls longevity, metabolism, and stress resistance in Caenorhabditis elegans. Hypoxia-inducible factor (HIF) protein levels are regulated through an evolutionarily conserved ubiquitin li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe0206d8fd3959878f3a709e0cb00b9
https://pubmed.ncbi.nlm.nih.gov/23566034
https://pubmed.ncbi.nlm.nih.gov/23566034
Autor:
Srinivas Ayyadevara, Robert J. Shmookler Reis, Eric R. Siegel, Puneet Bharill, Ramani Alla, Çagdaþ Tazearslan
Summary Two age-1 nonsense mutants, truncating the class-I phosphatidylinositol 3-kinase catalytic subunit (PI3KCS) before its kinase domain, confer extraordinary longevity and stress-resistance to Caenorhabditis elegans. These traits, unique to seco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b438f8bd6b22203f9c9e2722753c18
https://europepmc.org/articles/PMC2917200/
https://europepmc.org/articles/PMC2917200/
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 5, Iss 4, p e1000452 (2009)
PLoS Genetics, Vol 5, Iss 4, p e1000452 (2009)
Insulin/IGF-1 signaling (IIS) regulates development and metabolism, and modulates aging, of Caenorhabditis elegans. In nematodes, as in mammals, IIS is understood to operate through a kinase-phosphorylation cascade that inactivates the DAF-16/FOXO tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee28021e06d74d0dde299b466a69e8bc
https://pubmed.ncbi.nlm.nih.gov/19360094
https://pubmed.ncbi.nlm.nih.gov/19360094