MAT2A inhibition combats metabolic and transcriptional reprogramming in cancer.

Autor: Pulous FE; Insilico Medicine US Inc, 1000 Massachusetts Avenue, Suite 126, Cambridge, MA 02138, USA., Steurer B; Insilico Medicine US Inc, 1000 Massachusetts Avenue, Suite 126, Cambridge, MA 02138, USA., Pun FW; Insilico Medicine Hong Kong Ltd, Unit 310, 3/F, Building 8W, Hong Kong Science and Technology Park, Hong Kong SAR, China., Zhang M; Insilico Medicine Shanghai Ltd, 9F, Chamtime Plaza Block C, Lane 2889, Jinke Road, Pudong New Area, China., Ren F; Insilico Medicine Shanghai Ltd, 9F, Chamtime Plaza Block C, Lane 2889, Jinke Road, Pudong New Area, China., Zhavoronkov A; Insilico Medicine US Inc, 1000 Massachusetts Avenue, Suite 126, Cambridge, MA 02138, USA; Insilico Medicine Hong Kong Ltd, Unit 310, 3/F, Building 8W, Hong Kong Science and Technology Park, Hong Kong SAR, China; Insilico Medicine AI Ltd, Level 6, Unit 08, Block A, IRENA HQ Building, Masdar City, Abu Dhabi, UAE. Electronic address: alex@insilico.com.

Publikováno v: Drug discovery today [Drug Discov Today] 2024 Nov; Vol. 29 (11), pp. 104189. Date of Electronic Publication: 2024 Sep 19.

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

Autor: Lyu YX; Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China.; Max Planck Institute for Biology of Ageing, Cologne, Germany., Fu Q; Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China.; Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China.; Shandong Cellogene Pharmaceutics Co. LTD, Yantai, China., Wilczok D; Duke Kunshan University, Kunshan, Jiangsu, China.; Duke University, Durham, NC, USA., Ying K; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA., King A; Foresight Institute, San Francisco, CA 91125, USA., Antebi A; Max Planck Institute for Biology of Ageing, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Vojta A; Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia., Stolzing A; Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK., Moskalev A; Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia., Georgievskaya A; HautAI OÜ, Tallinn, Estonia., Maier AB; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Olsen A; California Institute of Technology, Pasadena, CA 91125, USA., Groth A; Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Simon AK; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; The Kennedy Institute of Rheumatology, Oxford, UK., Brunet A; Department of Genetics, Stanford University, Stanford, CA 94305, USA., Jamil A; Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE., Kulaga A; Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.; Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany., Bhatti A; America's Frontier Fund, VA 23320, USA., Yaden B; Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University - Purdue University Indianapolis, Indianapolis Indiana 46077, USA., Pedersen BK; Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark., Schumacher B; Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany., Djordjevic B; 199 Biotechnologies Ltd., London, UK.; University College London, London, UK., Kennedy B; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chen C; Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA.; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA., Huang CY; Hong Kong Quantum AI Lab, Hong Kong., Correll CU; Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA.; Charité - University Medicine, Berlin, Germany., Murphy CT; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA., Ewald CY; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland., Chen D; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.; Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.; Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA., Valenzano DR; Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany., Sołdacki D; Longevity Center Europe, Warsaw, Poland., Erritzoe D; Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK., Meyer D; Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany., Sinclair DA; Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA., Chini EN; Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA., Teeling EC; School of Biology and Environmental Science, Belfield, Univeristy College Dublin, Dublin 4, Ireland., Morgen E; BioAge Labs, Richmond, CA 94530, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA 94945, USA., Vernet E; Research and Early Development, Maaleov 2760, Denmark., Pinilla E; VitaDAO, Ottawa, ON K1V 9K6, Canada., Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway., Bischof E; Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Mercken EM; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark., Finger F; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark., Kuipers F; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Pun FW; Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China., Gyülveszi G; Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland., Civiletto G; Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland., Zmudze G; LongeVC, Riga, Latvia., Blander G; InsideTracker, Cambridge, MA 02114, USA., Pincus HA; Department of Psychiatry, Columbia University, New York, NY 10012, USA., McClure J; Maxwell Biosciences, Austin, TX 73301, USA., Kirkland JL; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Peyer J; Cambrian Bio, Inc., New York, NY 10012, USA., Justice JN; XPRIZE Foundation, Culver City, CA 90230, USA., Vijg J; Department of Genetics Albert Einstein College of Medicine, New York, NY 10461, USA., Gruhn JR; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., McLaughlin J; Life Biosciences, Boston, MA 02116, USA., Mannick J; Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA., Passos J; Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA., Baur JA; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA., Betts-LaCroix J; Retro Biosciences, Inc., Redwood City, CA 94061, USA., Sedivy JM; Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA., Speakman JR; Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Shlain J; Private Medical, San Francisco, CA 94107, USA., von Maltzahn J; Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany., Andreasson KI; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Moody K; Ichor Life Sciences, Inc., LaFayette, NY 13084, USA., Palikaras K; Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Fortney K; BioAge Labs, Richmond, CA 94530, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA., Rasmussen LJ; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark., Veenhoff LM; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Melton L; Nature Biotechnology, Springer Nature, London, UK., Ferrucci L; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA., Quarta M; Rubedo Life Sciences, Sunnyvale, CA 94043, USA.; Turn Biotechnologies, Mountain View 94039, CA, USA.; Phaedon Institute, Oakland, CA 94501, USA., Koval M; Institute of Biochemistry of the Romanian Academy, Romania., Marinova M; Fertility and Research Centre, Discipline of Women's Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Hamalainen M; Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA., Unfried M; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore., Ringel MS; Boston Consulting Group, Boston, MA 02210, USA., Filipovic M; Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany., Topors M; Repair Biotechnologies, Inc., Syracuse, NY 13210, USA., Mitin N; Sapere Bio, Triangle Research Park, NC 27213, USA., Roy N; Holmusk, New York, NY 10012, USA., Pintar N; AniBiome, Zagreb, Croatia., Barzilai N; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA., Binetti P; VitaDAO, Ottawa, ON K1V 9K6, Canada., Singh P; Buck Institute for Research on Aging, Novato, CA 94945, USA., Kohlhaas P; Molecule, Neuhausen am Rheinfall, Switzerland., Robbins PD; Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA., Rubin P; BioAge Labs, Richmond, CA 94530, USA., Fedichev PO; Gero PTE, Singapore, Singapore., Kamya P; Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8 Canada., Muñoz-Canoves P; Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA., de Cabo R; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, Maryland 21201, USA., Faragher RGA; Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK., Konrad R; Biolytica, Zug, Switzerland., Ripa R; Max Planck Institute for Biology of Ageing, Cologne, Germany., Mansukhani R; Deciduous Therapeutics, San Francisco, CA 94107, USA., Büttner S; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden., Wickström SA; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Brunemeier S; Healthspan Capital, El Cerrito, CA 94530, USA., Jakimov S; LongeVC, Riga, Latvia., Luo S; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong., Rosenzweig-Lipson S; Life Biosciences, Boston, MA 02116, USA., Tsai SY; Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Dimmeler S; Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany., Rando TA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA., Peterson TR; Bioio, Inc., St. Louis, MO 63110, USA., Woods T; Collider Heath, London, UK.; Healthy Longevity Champion, National Innovation Centre for Ageing, UK., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Finkel T; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA., Strauss T; Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel.; Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02108, USA., Longo VD; Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA., Dwaraka VB; TruDiagnostic, Lexington, KY 40503, USA., Gorbunova V; Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA., Acosta-Rodríguez VA; Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Sorrentino V; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sebastiano V; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA., Li W; Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China., Suh Y; Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA., Zhavoronkov A; Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE., Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark., Bakula D; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

Publikováno v: Aging [Aging (Albany NY)] 2024 Oct 16; Vol. 16 (20), pp. 12955-12976. Date of Electronic Publication: 2024 Oct 16.

Leveraging AI to identify dual-purpose aging and disease targets.

Autor: Leung GHD; Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park, Hong Kong, China., Wong CW; Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park, Hong Kong, China., Pun FW; Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park, Hong Kong, China., Aliper A; Insilico Medicine AI Ltd, Abu Dhabi, United Arab Emirates., Ren F; Insilico Medicine Shanghai Ltd, Shanghai, China., Zhavoronkov A; Insilico Medicine Hong Kong Ltd, Hong Kong Science and Technology Park, Hong Kong, China.; Insilico Medicine AI Ltd, Abu Dhabi, United Arab Emirates.; Buck Institute for Research on Aging, Novato, CA, USA.

Publikováno v: Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2024 Jun; Vol. 28 (6), pp. 473-476. Date of Electronic Publication: 2023 Dec 01.

PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery.

Autor: Kamya P; Insilico Medicine Canada Inc., 3710-1250 René-Lévesque Blvd. W, Montreal, Quebec, Canada H3B 4W8., Ozerov IV; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Pun FW; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Tretina K; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Fokina T; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Chen S; Insilico Medicine Shanghai Limited, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Naumov V; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Long X; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Lin S; Insilico Medicine Shanghai Limited, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Korzinkin M; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong., Polykovskiy D; Insilico Medicine Canada Inc., 3710-1250 René-Lévesque Blvd. W, Montreal, Quebec, Canada H3B 4W8., Aliper A; Insilico Medicine AI Limited, Level 6, Unit 08, Block A, IRENA HQ Building, P.O. Box 145748, Masdar City, Abu Dhabi, United Arab Emirates., Ren F; Insilico Medicine Shanghai Limited, Suite 901, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong New District, Shanghai 201203, China., Zhavoronkov A; Insilico Medicine Hong Kong Limited, Hong Kong Science and Technology Park, Hong Kong.; Insilico Medicine AI Limited, Level 6, Unit 08, Block A, IRENA HQ Building, P.O. Box 145748, Masdar City, Abu Dhabi, United Arab Emirates.; Buck Institute for Research on Aging, Novato, California 94945, United States.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2024 May 27; Vol. 64 (10), pp. 3961-3969. Date of Electronic Publication: 2024 Feb 25.

Applying Artificial Intelligence to Identify Common Targets for Treatment of Asthma, Eczema, and Food Allergy.

Autor: Liu HM; Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong, Hong Kong, China, bonnie.liu@insilico.com., Rayner A; Henry M. Gunn High School, Palo Alto, California, USA.; Regenerative Sciences Institute, Sunnyvale, California, USA., Mendelsohn AR; Regenerative Sciences Institute, Sunnyvale, California, USA., Shneyderman A; Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong, Hong Kong, China., Chen M; Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong, Hong Kong, China., Pun FW; Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong, Hong Kong, China.

Publikováno v: International archives of allergy and immunology [Int Arch Allergy Immunol] 2024; Vol. 185 (2), pp. 99-110. Date of Electronic Publication: 2023 Nov 21.