Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging.

Autor: Arriola Apelo SI; Department of Dairy Science, University of Wisconsin-Madison, Madison, United States.; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Lin A; Department of Dairy Science, University of Wisconsin-Madison, Madison, United States.; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Brinkman JA; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Meyer E; Department of Dairy Science, University of Wisconsin-Madison, Madison, United States.; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Morrison M; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Tomasiewicz JL; William S. Middleton Memorial Veterans Hospital, Madison, United States., Pumper CP; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Baar EL; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States., Richardson NE; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, United States., Alotaibi M; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, United States., Lamming DW; William S. Middleton Memorial Veterans Hospital, Madison, United States.; Department of Medicine, University of Wisconsin-Madison, Madison, United States.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, United States.; University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, United States.

Publikováno v: ELife [Elife] 2020 Jul 28; Vol. 9. Date of Electronic Publication: 2020 Jul 28.

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.

Autor: Arriola Apelo SI; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Neuman JC; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Interdisciplinary Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA., Baar EL; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Syed FA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Cummings NE; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA., Brar HK; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Pumper CP; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Kimple ME; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Interdisciplinary Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Interdisciplinary Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Endocrinology and Reproductive Physiology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin Carbone Cancer Center, Madison, WI, USA.

Publikováno v: Aging cell [Aging Cell] 2016 Feb; Vol. 15 (1), pp. 28-38. Date of Electronic Publication: 2015 Oct 13.

From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling.

Autor: Vo, Nathaniel, Qiwei Zhang, Hoon-Ki Sung

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences; 2024, p1-14, 14p

Rapamycin does not alter bone microarchitecture or material properties quality in young-adult and aged female C57BL/6 mice.

Autor: Devine, Connor C, Brown, Kenna C, Paton, Kat O, Heveran, Chelsea M, Martin, Stephen A

Publikováno v: JBMR Plus; Feb2024, Vol. 8 Issue 2, p1-10, 10p

The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage.

Autor: Shirzad, Shima, Vafaee, Farzaneh, Forouzanfar, Fatemeh

Publikováno v: Cellular & Molecular Neurobiology; Nov2023, Vol. 43 Issue 8, p4219-4230, 12p