Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Pumpens, P"'
Autor:
Dace Skrastina, Ivars Petrovskis, Ilva Lieknina, Janis Bogans, Regina Renhofa, Velta Ose, Andris Dishlers, Yuri Dekhtyar, Paul Pumpens
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114006 (2014)
Advances in nanotechnology and nanomaterials have facilitated the development of silicon dioxide, or Silica, particles as a promising immunological adjuvant for the generation of novel prophylactic and therapeutic vaccines. In the present study, we h
Externí odkaz:
https://doaj.org/article/12bad5f3bcae4beab56ceb1d8bc16ffb
Autor:
Milena Lange, Melanie Fiedler, Dorothea Bankwitz, William Osburn, Sergei Viazov, Olena Brovko, Abdel-Rahman Zekri, Yury Khudyakov, Michael Nassal, Paul Pumpens, Thomas Pietschmann, Jörg Timm, Michael Roggendorf, Andreas Walker
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102235 (2014)
Hepatitis C virus (HCV) infection is still a serious global health burden. Despite improved therapeutic options, a preventative vaccine would be desirable especially in undeveloped countries. Traditionally, highly conserved epitopes are targets for a
Externí odkaz:
https://doaj.org/article/494b5dace8e14b3e8d30f38535f02c0d
Autor:
Irina Sominskaya, Dace Skrastina, Ivars Petrovskis, Andris Dishlers, Ieva Berza, Maria Mihailova, Juris Jansons, Inara Akopjana, Irina Stahovska, Dzidra Dreilina, Velta Ose, Paul Pumpens
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75938 (2013)
An efficient pBR327- and Ptrp-based E. coli expression system was used to generate a large-scale library of virus like particles (VLP) formed by recombinant hepatitis B virus (HBV) core (HBc) protein derivatives. To construct the library, the gene of
Externí odkaz:
https://doaj.org/article/d1434cb5e39749f59f3d43f3fafc8cc0
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11703 (2010)
The rheumatoid arthritis (RA) shared epitope (SE), a major risk factor for severe disease, is a five amino acid motif in the third allelic hypervariable region of the HLA-DRbeta chain. The molecular mechanisms by which the SE affects susceptibility t
Externí odkaz:
https://doaj.org/article/83a0ebf9485b4ce3a7c586367f854e3f
Autor:
Alain C Tissot, Regina Renhofa, Nicole Schmitz, Indulis Cielens, Edwin Meijerink, Velta Ose, Gary T Jennings, Philippe Saudan, Paul Pumpens, Martin F Bachmann
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9809 (2010)
BACKGROUND: Recombinant proteins and in particular single domains or peptides are often poorly immunogenic unless conjugated to a carrier protein. Virus-like-particles are a very efficient means to confer high immunogenicity to antigens. We report he
Externí odkaz:
https://doaj.org/article/db42a84988b544db8609e97c6ce271ff
Autor:
Birgit Rabe, Mildred Delaleau, Andreas Bischof, Michael Foss, Irina Sominskaya, Paul Pumpens, Christian Cazenave, Michel Castroviejo, Michael Kann
Publikováno v:
PLoS Pathogens, Vol 5, Iss 8, p e1000563 (2009)
Assembly and disassembly of viral capsids are essential steps in the viral life cycle. Studies on their kinetics are mostly performed in vitro, allowing application of biochemical, biophysical and visualizing techniques. In vivo kinetics are poorly u
Externí odkaz:
https://doaj.org/article/3428e2e01b054f139d717c7dcfcc80bc
Autor:
Beck Markus, Keller Iris, Martina Byron EE, Jennings Gary T, Spohn Gunther, Pumpens Paul, Osterhaus Albert DME, Bachmann Martin F
Publikováno v:
Virology Journal, Vol 7, Iss 1, p 146 (2010)
Abstract Background Since its first appearance in the USA in 1999, West Nile virus (WNV) has spread in the Western hemisphere and continues to represent an important public health concern. In the absence of effective treatment, there is a medical nee
Externí odkaz:
https://doaj.org/article/bf66e4aef2e34c67b95243be637d4003
Akademický článek
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Akademický článek
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Autor:
Schmitz, N, Beerli, R, Bauer, M, Jegerlehner, A, Dietmeier, K, Maudrich, M, Pumpens, P, Saudan, P, Bachmann, M
Publikováno v:
European journal of immunology. 42(4)
A vaccine protecting against all influenza strains is a long-sought goal, particularly for emerging pandemics. As previously shown, vaccines based on the highly conserved extracellular domain of M2 (M2e) may protect against all influenza A strains. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d5627bf3745ea9dedac887e0759aaa16
http://ora.ox.ac.uk/objects/uuid:da96cc77-3aa4-446a-8faf-529752b3f829
http://ora.ox.ac.uk/objects/uuid:da96cc77-3aa4-446a-8faf-529752b3f829