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of 4
pro vyhledávání: '"Pulugurta, Rishab"'
Peptide therapeutics, including macrocycles, peptide inhibitors, and bioactive linear peptides, play a crucial role in therapeutic development due to their unique physicochemical properties. However, predicting these properties remains challenging. W
Externí odkaz:
http://arxiv.org/abs/2410.20667
Autor:
Chen, Tianlai, Dumas, Madeleine, Watson, Rio, Vincoff, Sophia, Peng, Christina, Zhao, Lin, Hong, Lauren, Pertsemlidis, Sarah, Shaepers-Cheu, Mayumi, Wang, Tian Zi, Srijay, Divya, Monticello, Connor, Vure, Pranay, Pulugurta, Rishab, Kholina, Kseniia, Goel, Shrey, DeLisa, Matthew P., Truant, Ray, Aguilar, Hector C., Chatterjee, Pranam
Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity strategies, such as PROTACs and molecular glues, have thus gained attention as pharmacological
Externí odkaz:
http://arxiv.org/abs/2310.03842
Autor:
Chen T; Department of Biomedical Engineering, Duke University., Dumas M; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University.; Department of Microbiology, College of Agriculture and Life Sciences, Cornell University., Watson R; Department of Biomedical Engineering, Duke University., Vincoff S; Department of Biomedical Engineering, Duke University., Peng C; Department of Biochemistry and Biomedical Sciences, McMaster University., Zhao L; Department of Biomedical Engineering, Duke University., Hong L; Department of Biomedical Engineering, Duke University., Pertsemlidis S; Department of Biomedical Engineering, Duke University., Shaepers-Cheu M; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University., Wang TZ; Department of Biomedical Engineering, Duke University., Srijay D; Department of Biomedical Engineering, Duke University., Monticello C; Department of Biochemistry and Biomedical Sciences, McMaster University., Vure P; Department of Biomedical Engineering, Duke University., Pulugurta R; Department of Biomedical Engineering, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Goel S; Department of Biomedical Engineering, Duke University., DeLisa MP; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.; Cornell Institute of Biotechnology, Cornell University, Ithaca, NY, USA., Truant R; Department of Biochemistry and Biomedical Sciences, McMaster University., Aguilar HC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.
Publikováno v:
ArXiv [ArXiv] 2024 Aug 11. Date of Electronic Publication: 2024 Aug 11.
Autor:
Vincoff S; Department of Biomedical Engineering, Duke University., Goel S; Department of Computer Science, Duke University., Kholina K; Department of Biomedical Engineering, Duke University., Pulugurta R; Department of Biomedical Engineering, Duke University., Vure P; Department of Biomedical Engineering, Duke University., Chatterjee P; Department of Biomedical Engineering, Duke University.; Department of Computer Science, Duke University.; Department of Biostatistics and Bioinformatics, Duke University.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 04. Date of Electronic Publication: 2024 Jun 04.