Výsledky vyhledávání - "Pullooru Bhanumoorthy"

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics

Autor: David E. Timm, Ronald W. McClard, Thomas D. Hurley, Markus Grompe, Raynard L. Bateman, L.-J. Baker, John F. Witte, Justin Ashworth, Pullooru Bhanumoorthy

Publikováno v: Biochemical Journal. 402:251-260

FAH (fumarylacetoacetate hydrolase) catalyses the final step of tyrosine catabolism to produce fumarate and acetoacetate. HT1 (hereditary tyrosinaemia type 1) results from deficiency of this enzyme. Previously, we prepared a partial mimic of the puta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b37ffbe71334da191b79933cdbf3a7
https://doi.org/10.1042/bj20060961

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Akademický článek

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.

Autor: Raynard L. Bateman, Justin Ashworth, John F. Witte, L.-J. Baker, Pullooru Bhanumoorthy, David E. Timm, Thomas D. Hurley, Markus Grompe, Ronald W. McClard

Publikováno v: Biochemical Journal; 2007, Vol. 402 Issue 2, p251-260, 10p

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