Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity.

Autor: Awad D; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.; UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas., Cao PHA; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.; UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas., Pulliam TL; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Spradlin M; Department of Chemistry, The University of Texas at Austin, Austin, Texas.; Department of Surgery, Baylor College of Medicine, Houston, Texas., Subramani E; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Tellman TV; UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas., Ribeiro CF; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Muzzioli R; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jewell BE; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Pakula H; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Ackroyd JJ; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Murray MM; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Han JJ; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Leng M; Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, Texas., Jain A; Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, Texas., Piyarathna B; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas., Liu J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Song X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Klekers AR; Department of Abdominal Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Drake JM; Departments of Pharmacology and Urology, University of Minnesota, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, Minnesota., Ittmann MM; Departments of Pathology and Immunology, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Cancer Center, Houston, Texas.; Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas., Piwnica-Worms D; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas., Farach-Carson MC; Department of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Eberlin LS; Department of Surgery, Baylor College of Medicine, Houston, Texas., Frigo DE; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas.; Department of Biology and Biochemistry, University of Houston, Houston, Texas.

Publikováno v: Cancer research [Cancer Res] 2024 Mar 04; Vol. 84 (5), pp. 703-724.

Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.

Autor: Pulliam TL; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Awad D; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA., Han JJ; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Murray MM; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Ackroyd JJ; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Goli P; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Oakhill JS; St Vincent's Institute of Medical Research, Melbourne, VIC 3065, Australia., Scott JW; St Vincent's Institute of Medical Research, Melbourne, VIC 3065, Australia.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, VIC 3065, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia., Ittmann MM; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.; Dan L. Duncan Cancer Center, Houston, TX 77030, USA.; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA., Frigo DE; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204, USA.; Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Publikováno v: Cells [Cells] 2022 Jun 10; Vol. 11 (12). Date of Electronic Publication: 2022 Jun 10.

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.

Autor: Eduful BJ; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., O'Byrne SN; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Temme L; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Asquith CRM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Liang Y; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Picado A; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Pilotte JR; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Hossain MA; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Wells CI; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Zuercher WJ; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Catta-Preta CMC; Centro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo 13083-875, Brazil.; Structural Genomics Consortium, Departamento de Genética e Evolução, Instituto de Biologia, UNICAMP, Campinas, São Paulo 13083-886, Brazil., Zonzini Ramos P; Centro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo 13083-875, Brazil.; Structural Genomics Consortium, Departamento de Genética e Evolução, Instituto de Biologia, UNICAMP, Campinas, São Paulo 13083-886, Brazil., Santiago AS; Centro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo 13083-875, Brazil.; Structural Genomics Consortium, Departamento de Genética e Evolução, Instituto de Biologia, UNICAMP, Campinas, São Paulo 13083-886, Brazil., Couñago RM; Centro de Química Medicinal (CQMED), Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo 13083-875, Brazil.; Structural Genomics Consortium, Departamento de Genética e Evolução, Instituto de Biologia, UNICAMP, Campinas, São Paulo 13083-886, Brazil., Langendorf CG; St Vincent's Institute and Department of Medicine, The University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia., Nay K; St Vincent's Institute and Department of Medicine, The University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, 215 Spring Street, Melbourne 3000, Australia., Oakhill JS; St Vincent's Institute and Department of Medicine, The University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, 215 Spring Street, Melbourne 3000, Australia., Pulliam TL; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas 77204, United States.; Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, United States., Lin C; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas 77030, United States., Awad D; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas 77030, United States., Willson TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Frigo DE; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas 77204, United States.; Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, United States.; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.; The Methodist Hospital Research Institute, Houston, Texas 77030, United States., Scott JW; St Vincent's Institute and Department of Medicine, The University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, 215 Spring Street, Melbourne 3000, Australia.; The Florey Institute of Neuroscience and Mental Health, 30 Royal Parade, Parkville 3052, Australia., Drewry DH; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; UNC Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 10849-10877. Date of Electronic Publication: 2021 Jul 15.

Prostate Cancer Energetics and Biosynthesis.

Autor: Lin C; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Salzillo TC; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Bader DA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Wilkenfeld SR; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Awad D; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Pulliam TL; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA.; Department of Biology and Biochemistry, University of Houston, Houston, TX, USA., Dutta P; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pudakalakatti S; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Titus M; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McGuire SE; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bhattacharya PK; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Health Science Center at Houston, Houston, TX, USA., Frigo DE; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. frigo@mdanderson.org.; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA. frigo@mdanderson.org.; Department of Biology and Biochemistry, University of Houston, Houston, TX, USA. frigo@mdanderson.org.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. frigo@mdanderson.org.; Molecular Medicine Program, The Houston Methodist Research Institute, Houston, TX, USA. frigo@mdanderson.org.

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2019; Vol. 1210, pp. 185-237.

GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.

Autor: White MA; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA., Tsouko E; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA., Lin C; Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA., Rajapakshe K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., Spencer JM; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA., Wilkenfeld SR; Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA., Vakili SS; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA., Pulliam TL; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA.; Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA., Awad D; Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA., Nikolos F; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., Katreddy RR; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA., Kaipparettu BA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA., Sreekumar A; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA., Zhang X; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA., Cheung E; Biology and Pharmacology, Genome Institute of Singapore, A*STAR, Singapore, Singapore.; Faculty of Health Sciences, University of Macau, Taipa, Macau, China., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., Frigo DE; Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA.; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA.; Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.; Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.; Molecular Medicine Program, The Houston Methodist Research Institute, Houston, Texas, USA.

Publikováno v: Endocrine-related cancer [Endocr Relat Cancer] 2018 Apr; Vol. 25 (4), pp. 453-469. Date of Electronic Publication: 2018 Feb 05.