Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pulak Tripathi"'
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/862fc49caa3b44738e41013affe9889a
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A major goal of genetics research is to elucidate mechanisms explaining how genetic variation contributes to phenotypic variation. The genetic variants identified in genome-wide association studies (GWASs) generally explain only a small proportion of
Externí odkaz:
https://doaj.org/article/dd041971c2394d2ab5f83d0c3eb48caa
Autor:
Fukun Guo, Shuangmin Zhang, Pulak Tripathi, Jochen Mattner, James Phelan, Alyssa Sproles, Jun Mo, Marsha Wills-Karp, H Leighton Grimes, David Hildeman, Yi Zheng
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18002 (2011)
Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific. By a T cell-specific deletion of Cdc42 in mouse, we have recently shown tha
Externí odkaz:
https://doaj.org/article/56edbda6e08a40a5abba09afabedcc09
Publikováno v:
Genetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f6c8e516485f2cfb766c71aa69e9e6
https://doi.org/10.1136/lupus-2022-lupus21century.60
https://doi.org/10.1136/lupus-2022-lupus21century.60
Autor:
Charles Perkins, David A. Hildeman, Suzanne C. Morris, Pulak Tripathi, Allyson Sholl, Fred D. Finkelman
Publikováno v:
European Journal of Immunology. 46:2333-2339
Virtual memory (VM) CD8+ T cells are present in unimmunized mice, yet possess T-cell receptors specific for foreign antigens. To date, VM cells have only been characterized in C57BL/6 mice. Here, we assessed the cytokine requirements for VM cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e2489e6ed5511f9b480ad4b2b49823
https://doi.org/10.1002/eji.201646404
https://doi.org/10.1002/eji.201646404
Autor:
Allyson Sholl, Celine S. Lages, David R. Plas, David A. Hildeman, Pamela J. Fink, Pulak Tripathi, Claire A. Chougnet, Jana Raynor
Publikováno v:
The Journal of Immunology. 186:156-163
We have previously shown that regulatory T cells (Treg) accumulate dramatically in aged animals and negatively impact the ability to control persistent infection. However, the mechanisms underlying the age-dependent accrual of Treg remain unclear. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0c1b65ba4422416240756cd3211675
https://doi.org/10.4049/jimmunol.1001505
https://doi.org/10.4049/jimmunol.1001505
Autor:
David A. Hildeman, Pulak Tripathi, Fukun Guo, H. Leighton Grimes, Chinavenmeni S. Velu, Yi Zheng
Publikováno v:
Proceedings of the National Academy of Sciences. 107:18505-18510
T-cell homeostasis is essential for normal functioning of the immune system. IL-7 receptor (IL-7R) and T-cell receptor (TCR) signaling are pivotal for T-cell homeostatic regulation. The detailed mechanisms regulating T-cell homeostasis and how IL-7R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdfc6b1a201f09d717d21f715306440
https://doi.org/10.1073/pnas.1010249107
https://doi.org/10.1073/pnas.1010249107
Autor:
Suzanne C. Morris, David A. Hildeman, Allyson Sholl, Pulak Tripathi, H. Leighton Grimes, Kasper Hoebe, Sema Kurtulus, Sara Wojciechowski, Fred D. Finkelman
Publikováno v:
The Journal of Immunology. 185:2116-2124
During an immune response, most effector T cells die, whereas some are maintained and become memory T cells. Factors controlling the survival of effector CD4+ and CD8+ T cells remain unclear. In this study, we assessed the role of IL-7, IL-15, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b72d20b67dcbd3aaacdc8987293fe1
https://doi.org/10.4049/jimmunol.1000842
https://doi.org/10.4049/jimmunol.1000842
Publikováno v:
Immunological Reviews. 236:54-67
Maintenance of T-cell homeostasis is critical for normal functioning of the immune system. After thymocyte selection, T cells enter the peripheral lymphoid organs, where they are maintained as naive cells. Transient disruption of homeostasis occurs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bac037270d58e2ff872841b77fbf3a3
https://doi.org/10.1111/j.1600-065x.2010.00920.x
https://doi.org/10.1111/j.1600-065x.2010.00920.x
Autor:
Aaron J. Johnson, Georgette L. Suidan, Kim B. Seroogy, Yi Chen, Istvan Pirko, Pulak Tripathi, Jeremiah McDole, Jonathan W. Dickerson
Publikováno v:
The Journal of Immunology. 184:1031-1040
Dysregulation of the blood-brain barrier (BBB) is a hallmark feature of numerous neurologic disorders as diverse as multiple sclerosis, stroke, epilepsy, viral hemorrhagic fevers, cerebral malaria, and acute hemorrhagic leukoencephalitis. CD8 T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff34e20d7aac67967848e1030911810e
https://doi.org/10.4049/jimmunol.0902773
https://doi.org/10.4049/jimmunol.0902773