Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Pulak K. Chakraborty"'
Autor:
Otto Muzik, Csaba Juhász, Sandeep Mittal, Pulak K. Chakraborty, Kaushik Varadarajan, David O. Kamson, Natasha L. Robinette, Michael Snyder, Geoffrey R. Barger, Tiffany J. Lee
Publikováno v:
Journal of Nuclear Medicine. 55:1605-1610
α-(11)C-methyl-L-tryptophan (AMT) PET allows evaluation of brain serotonin synthesis and can also track upregulation of the immunosuppressive kynurenine pathway in tumor tissue. Increased AMT uptake is a hallmark of World Health Organization grade I
Autor:
Majid Janabi, Csaba Juhász, Rouba Ali-Fehmi, Diane C. Chugani, Thomas J. Mangner, Pulak K. Chakraborty, Otto Muzik, Ian M Zitron, Zeina Nahleh, Sandeep Mittal, Sudeshna Bandyopadhyay
Publikováno v:
Nuclear Medicine and Biology. 39:926-932
Tryptophan oxidation via the kynurenine pathway is an important mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin pathway has been linked to malignant progression in breast cancer. In this study, we combined qua
Autor:
Pulak K. Chakraborty, Tong Shi, David C. Markel, Weiping Ren, Jeffrey C. Flynn, Otto Muzik, Nancy Jackson, Basma Khoury
Publikováno v:
Nuclear Medicine Communications. 33:747-756
PURPOSE This study aims to determine the value of PET with C-isoquinoline carboxamide (C-PK11195) and F-fluorodeoxyglucose (F-FDG) in assisting the differentiation of aseptic loosening (AL) from septic loosening (SL) in rat models. PROCEDURES Initial
Autor:
Diane C. Chugani, Pulak K. Chakraborty, Natasha L. Robinette, Geoffrey R. Barger, William J. Kupsky, Otto Muzik, Bálint Alkonyi, Sandeep Mittal, Gautam Bahl, Csaba Juhász
Publikováno v:
Journal of Nuclear Medicine. 53:1058-1064
PET of amino acid transport and metabolism may be more accurate than conventional neuroimaging in differentiating recurrent gliomas from radiation-induced tissue changes. α-(11)C-methyl-l-tryptophan ((11)C-AMT) is an amino acid PET tracer that is no
Publikováno v:
Journal of Child Neurology. 27:598-603
In this study, we determined whether diffusion tensor imaging (DTI), a more widely available imaging modality, is as effective as α-[11C]methyl-l-tryptophan (AMT)–positron emission tomography (PET) in localizing epileptogenic tubers in tuberous sc
Publikováno v:
Pediatric Neurology. 44:143-146
We present findings of (11)C-[R]-PK11195 positron emission tomography in a child with X-linked adrenoleukodystrophy. (11)C-[R]-PK11195 is a radioligand with a high and specific affinity for peripheral benzodiazepine receptors, expressed by activated
Autor:
Roberto Romero, Xin Lu, Otto Muzik, Fadoua Saadani-Makki, Diane C. Chugani, James Janisse, Pulak K. Chakraborty, Bindu Balakrishnan, Sujatha Kannan
Publikováno v:
Developmental Neuroscience. 33:231-240
Intrauterine inflammation is known to be a risk factor for the development of periventricular leukomalacia (PVL) and cerebral palsy. In recent years, activated microglial cells have been implicated in the pathogenesis of PVL and in the development of
Autor:
Aashit Shah, William J. Kupsky, Otto Muzik, Craig Watson, Sandeep Sood, Andrew E. Sloan, Tom J Mangner, Pulak K. Chakraborty, Dafang Wu, Diane C. Chugani, Harry T. Chugani, Geoffrey Barger, Eser Lay Ergun, Csaba Juhász
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 26:345-357
Abnormal metabolism of tryptophan has been implicated in modulation of tumor cell proliferation and immunoresistance. α-[11C]Methyl-l-tryptophan (AMT) is a PET tracer to measure cerebral tryptophan metabolism in vivo. In the present study, we have m
Autor:
Harry T. Chugani, Pulak K. Chakraborty, Otto Muzik, Dilip K. Maiti, Diane C. Chugani, Thomas J. Mangner
Publikováno v:
Applied Radiation and Isotopes. 62:721-727
An improved one-pot synthesis procedure for routine production of [carbonyl-(11)C]desmethyl-WAY-100635 ([(11)C]DWAY) is described. An efficient purification of the crude product has also been developed and was accomplished by C-18 reversed-phase semi
Autor:
Sandeep Sood, Uma N. Padhye, Otto Muzik, Harry T. Chugani, Diane C. Chugani, Pulak K. Chakraborty, Eishi Asano, Aashit Shah, Csaba Juhász, Tom J. Mangner
Publikováno v:
Epilepsia. 45:124-130
Summary: Purpose: Reoperation after failed cortical resection can alleviate seizures in patients with intractable neocortical epilepsy, provided that previously nonresected epileptic regions are accurately defined and removed. Most imaging modalities