Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Puja R. Mehta"'
Autor:
Sarah Opie-Martin, Alfredo Iacoangeli, Simon D. Topp, Olubunmi Abel, Keith Mayl, Puja R. Mehta, Aleksey Shatunov, Isabella Fogh, Harry Bowles, Naomi Limbachiya, Thomas P. Spargo, Ahmad Al-Khleifat, Kelly L. Williams, Jennifer Jockel-Balsarotti, Taha Bali, Wade Self, Lyndal Henden, Garth A. Nicholson, Nicola Ticozzi, Diane McKenna-Yasek, Lu Tang, Pamela J. Shaw, Adriano Chio, Albert Ludolph, Jochen H. Weishaupt, John E. Landers, Jonathan D. Glass, Jesus S. Mora, Wim Robberecht, Philip Van Damme, Russell McLaughlin, Orla Hardiman, Leonard van den Berg, Jan H. Veldink, Phillippe Corcia, Zorica Stevic, Nailah Siddique, Vincenzo Silani, Ian P. Blair, Dong-sheng Fan, Florence Esselin, Elisa de la Cruz, William Camu, Nazli A. Basak, Teepu Siddique, Timothy Miller, Robert H. Brown, Ammar Al-Chalabi, Christopher E. Shaw
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/8e0ad59b00f44e48822c11311414e619
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of incurable, heterogeneous, and in
Externí odkaz:
https://doaj.org/article/c2741b5e80194d549e3f338eb6ddeb60
The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
Autor:
Sarah Opie-Martin, Alfredo Iacoangeli, Simon D. Topp, Olubunmi Abel, Keith Mayl, Puja R. Mehta, Aleksey Shatunov, Isabella Fogh, Harry Bowles, Naomi Limbachiya, Thomas P. Spargo, Ahmad Al-Khleifat, Kelly L. Williams, Jennifer Jockel-Balsarotti, Taha Bali, Wade Self, Lyndal Henden, Garth A. Nicholson, Nicola Ticozzi, Diane McKenna-Yasek, Lu Tang, Pamela J. Shaw, Adriano Chio, Albert Ludolph, Jochen H. Weishaupt, John E. Landers, Jonathan D. Glass, Jesus S. Mora, Wim Robberecht, Philip Van Damme, Russell McLaughlin, Orla Hardiman, Leonard van den Berg, Jan H. Veldink, Phillippe Corcia, Zorica Stevic, Nailah Siddique, Vincenzo Silani, Ian P. Blair, Dong-sheng Fan, Florence Esselin, Elisa de la Cruz, William Camu, Nazli A. Basak, Teepu Siddique, Timothy Miller, Robert H. Brown, Ammar Al-Chalabi, Christopher E. Shaw
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Abstract Superoxide dismutase (SOD1) gene variants may cause amyotrophic lateral sclerosis, some of which are associated with a distinct phenotype. Most studies assess limited variants or sample sizes. In this international, retrospective observation
Externí odkaz:
https://doaj.org/article/3a2b8e9a76094f53a4b32e441bb751a4
Autor:
Paris Hosseini, Rebecca Whincup, Karrish Devan, Dory Anthony Ghanem, Jack B. Fanshawe, Aman Saini, Benjamin Cross, Apoorva Vijay, Tomas Mastellari, Umesh Vivekananda, Steven White, Franz Brunnhuber, Michael S. Zandi, Anthony S. David, Ben Carter, Dominic Oliver, Glyn Lewis, Charles Fry, Puja R. Mehta, Biba Stanton, Jonathan P. Rogers
Publikováno v:
EClinicalMedicine, Vol 56, Iss , Pp 101808- (2023)
Summary: Background: Catatonia is a psychomotor syndrome that has a wide range of aetiologies. Determining whether catatonia is due to a medical or psychiatric cause is important for directing treatment but is clinically challenging. We aimed to asce
Externí odkaz:
https://doaj.org/article/24da5b696f3f4f7e9227c000a6761a8d
Autor:
Laura A. Benjamin, Ross W. Paterson, Rachel Moll, Charis Pericleous, Rachel Brown, Puja R. Mehta, Dilan Athauda, Oliver J. Ziff, Judith Heaney, Anna M. Checkley, Catherine F. Houlihan, Michael Chou, Amanda J. Heslegrave, Arvind Chandratheva, Benedict D. Michael, Kaj Blennow, Vinojini Vivekanandam, Alexander Foulkes, Catherine J. Mummery, Michael P. Lunn, Stephen Keddie, Moira J. Spyer, Tom Mckinnon, Melanie Hart, Francesco Carletti, Hans Rolf Jäger, Hadi Manji, Michael S. Zandi, David J. Werring, Eleni Nastouli, Robert Simister, Tom Solomon, Henrik Zetterberg, Jonathan M. Schott, Hannah Cohen, Maria Efthymiou
Publikováno v:
EClinicalMedicine, Vol 39, Iss , Pp 101070- (2021)
Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.
Externí odkaz:
https://doaj.org/article/3eef6c9f06c243ceb51ecb95ba2fa15f
Autor:
Oliver J. Ziff, Nicholas J. Ashton, Puja R. Mehta, Rachel Brown, Dilan Athauda, Judith Heaney, Amanda J. Heslegrave, Andrea Lessa Benedet, Kaj Blennow, Anna M. Checkley, Catherine F. Houlihan, Serge Gauthier, Pedro Rosa‐Neto, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Laura A. Benjamin, Ross W. Paterson
Publikováno v:
Journal of Neurochemistry. 161:146-157
SARS-CoV-2 infection can damage the nervous system with multiple neurological manifestations described. However, there is limited understanding of the mechanisms underlying COVID-19 neurological injury. This is a cross-sectional exploratory prospecti
Autor:
Priya, Rogers, Ieuan, Walker, Jason, Yeung, Abeera, Khan, Anmol, Gangi, Behnaz, Mobashwera, Robert, Ayto, Ali, Shah, Joannes, Hermans, Andrew, Murchison, Matthew, Benger, Sean, Apap Mangion, Puja R, Mehta, Laszlo, Sztriha, Simrit, Ghatorae, Brian, Craven, Marie, Scully, Timothy, Bray, Margaret, Hall-Craggs, Conrad, von Stempel
Publikováno v:
Radiology. 305(3)
Vaccination strategies have been at the forefront of controlling the COVID-19 pandemic. An association between vaccine-induced immune thrombotic thrombocytopenia (VITT) and one of these vaccines, the ChAdOx1 nCov-19 vaccine, is now recognized. The pu
Publikováno v:
The Journal of pathologyReferences. 257(3)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. Despite the unifying pathological hallmark of TDP-43 proteinopathy, ALS is clinically a highly heterogeneous disease, and little is known about the underlying mechanisms drivi
Autor:
I, Ashmole, D V, Vavoulis, P J, Stansfeld, Puja R, Mehta, J F, Feng, M J, Sutcliffe, P R, Stanfield
Publikováno v:
The Journal of Physiology
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through
Autor:
Gowland, Alison, Opie-Martin, Sarah, Scott, Kirsten M., Jones, Ashley R., Puja R. Mehta, Batts, Christine J., Ellis, Cathy M., P. Nigel Leigh, Shaw, Christopher E., Jemeen Sreedharan, Al-Chalabi, Ammar
Objective: To model the effects of demographic change under various scenarios of possible future treatment developments in ALS. Methods: Patients diagnosed with ALS at the King’s College Hospital Motor Nerve Clinic between 2004 and 2017, and living
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adae4206ca4baafce2b36d62b9bc12b