Zobrazeno 1 - 10
of 26
pro vyhledávání: '"PuiYee Chan"'
Autor:
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 495-503 (2014)
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcr
Externí odkaz:
https://doaj.org/article/04aad9faacbb4c398538fe8973f616b7
Autor:
Peter G. Mikhael, Jeremy Wohlwend, Adam Yala, Ludvig Karstens, Justin Xiang, Angelo K. Takigami, Patrick P. Bourgouin, PuiYee Chan, Sofiane Mrah, Wael Amayri, Yu-Hsiang Juan, Cheng-Ta Yang, Yung-Liang Wan, Gigin Lin, Lecia V. Sequist, Florian J. Fintelmann, Regina Barzilay
Publikováno v:
Journal of Clinical Oncology. 41:2191-2200
PURPOSE Low-dose computed tomography (LDCT) for lung cancer screening is effective, although most eligible people are not being screened. Tools that provide personalized future cancer risk assessment could focus approaches toward those most likely to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96da1647fb094806b8f8f3f614b70bf1
https://doi.org/10.1200/jco.22.01345
https://doi.org/10.1200/jco.22.01345
Autor:
Kamil Slowikowski, Molly Thomas, Kasidet Manakongtreecheep, Pritha Sen, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal Smith, Alice Tirard, Swetha Ramesh, Benjamin Arnold, Linda Nieman, Jonathan Chen, Thomas Eisenhaure, Karin Pelka, Katherine Xu, Vjola Jorgji, Christopher Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan Sullivan, Hamed Khalili, Dejan Juric, Genevieve Boland, Michael Dougan, Nir Hacohen, Bo Li, Kerry Reynolds, Alexandra-Chloé Villani
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d6fac31448a319f6cea960113585b8
https://doi.org/10.1136/jitc-2022-sitc2022.1242
https://doi.org/10.1136/jitc-2022-sitc2022.1242
Autor:
Gary Reynolds, Mazen Nasrallah, Neal Smith, Molly Thomas, Leyre Zubiri, Alice Tirard, John McGuire, Kasidet Manakongtreecheep, Jessica Tantivit, Steven Blum, Daniel Zlotoff, Elaina PuiYee Chan, Dejan Juric, Ryan Sullivan, Genevieve Boland, Andrew Luster, Sara Schoenfeld, Minna Kohler, Kerry Reynolds, Chloe Villani
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0280aa94587a75feadfe16e3238e6832
https://doi.org/10.1136/jitc-2022-sitc2022.0441
https://doi.org/10.1136/jitc-2022-sitc2022.0441
Autor:
Kamil Slowikowski, Benjamin Y. Arnold, Leyre Zubiri, Katherine Xu, Bo Li, Dejan Juric, Christopher J. Pinto, Swetha Ramesh, Michael Dougan, Jonathan H. Chen, Tatyana Sharova, Genevieve M. Boland, Karin Pelka, Elaina PuiYee Chan, Linda T. Nieman, Molly Thomas, Jessica Tantivit, Pritha Sen, Hamed Khalili, Alice Tirard, Mazen Nasrallah, Rachel Glasser, Alexandra-Chloé Villani, Neal P. Smith, Vjola Jorgji, Ryan J. Sullivan, Kasidet Manakongtreecheep, Kerry L. Reynolds, Nir Hacohen, Thomas Eisenhaure
Therapeutic blockade of co-inhibitory immune receptors PD-1 and CTLA-4 has revolutionized oncology, but treatments are limited by immune-related adverse events (IRAEs). IRAE Colitis (irColitis) is the most common, severe IRAE affecting up to 25% of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72e208dc156375234ab358e6b64f874
https://doi.org/10.1101/2021.09.17.460868
https://doi.org/10.1101/2021.09.17.460868
Autor:
Julia Pollak, Kristy Potts, PuiYee Chan, Chen-Hsun Tsai, Angela Liao, Carly Garrison, Taylor Brown, Paul Stull, Zhen Li, Christine Baker, Kavita Garg, Ira Pekker, Michael Farabaugh, Michael Gormley, Lesley Farrington, Katherine Bell, Usha Singh
Publikováno v:
Cancer Research. 82:52-52
Tumor cells of metastatic castration-resistant prostate cancer (mCRPC) patients with homologous recombination deficiency (HRD) are highly sensitive to the blockade of DNA single-strand break repair via the inhibition of the poly(adenosine diphosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4cee0caad6bc84cca67bf10d7cd0dd
https://doi.org/10.1158/1538-7445.am2022-52
https://doi.org/10.1158/1538-7445.am2022-52
Autor:
Ira Pekker, Julia Pollak, Kristy Potts, PuiYee Chan, Chen-Hsun Tsai, Angela Liao, Carly Garrison, Taylor Brown, Paul Stull, Daniella Bianchi-Frias, Zhen Li, Christine Baker, Kavita Garg
Publikováno v:
Journal of Clinical Oncology. 40:3057-3057
3057 Background: KRAS is one of the most commonly mutated oncogenes in cancer. There is a significant need for new treatment options for patients with non–small cell lung cancer (NSCLC) harboring the KRAS G12C mutation. Adagrasib is an investigatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70785d98b7932028325c07d1056f7a2
https://doi.org/10.1200/jco.2022.40.16_suppl.3057
https://doi.org/10.1200/jco.2022.40.16_suppl.3057
Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal
Autor:
Jong-Ryoul Choi, Michael DeRan, Baoen Chen, Jixiao Niu, Gopala K. Jarugumilli, Yang Sun, PuiYee Chan, Meilan Yu, Xu Wu, Cheng Lin, Baohui Zheng, Raphael A. Zoeller
Publikováno v:
ACS Chemical Biology. 13:1130-1136
Lipid-derived electrophiles (LDEs) are reactive metabolites, which can covalently modify proteins and DNA and regulate diverse cellular processes. 2- trans-Hexadecenal (2-HD) is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorgan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102f8579bc74f239dcc0d2deb0585f4
https://doi.org/10.1021/acschembio.7b01063
https://doi.org/10.1021/acschembio.7b01063
Autor:
Jennifer L. Cotton, Gopala K. Jarugumilli, Michael DeRan, Rui Li, Jordi Xiol, Xu Wu, Xuelian Luo, Randy L. Johnson, Y. Tony Ip, Lihua Julie Zhu, Junhao Mao, Qi Li, Yang Sun, Joyce Li, Andrew B. Leiter, Kyvan Dang, PuiYee Chan, Shun Liu, Lifang Ma, Fernando D. Camargo
Publikováno v:
Cell stem cell. 26(5)
Summary Intestinal homeostasis is tightly regulated by complex yet poorly understood signaling networks. Here, we demonstrate that Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intestinal stem cells. Lats1/2 dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1471e5f2d2ea7b677b93eaa99fb484
https://pubmed.ncbi.nlm.nih.gov/32386550
https://pubmed.ncbi.nlm.nih.gov/32386550
Autor:
Xiao Han, Hua Deng, Duojia Pan, Baohui Zheng, Gopala K. Jarugumilli, Michael DeRan, Jianzhong Yu, Xu Wu, Xuelian Luo, PuiYee Chan
Publikováno v:
Nature chemical biology
TEA domain (TEAD) transcription factors bind to the coactivators YAP and TAZ and regulate the transcriptional output of the Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation attaches a fatty acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844fd98ad57151610691db7de55b6d39
http://europepmc.org/articles/PMC4798901
http://europepmc.org/articles/PMC4798901