Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Pui-Yee Ng"'
Autor:
Richard B. Pearson, Ross D. Hannan, Grant A. McArthur, Ricky W. Johnstone, Sean O'Brien, Denis Drygin, Jian Kang, Elaine Sanij, Gretchen Poortinga, Megan J. Bywater, Jake Shortt, Amee J. George, Pui Yee Ng, Eric Kusnadi, Carleen Cullinane, Nadine Hein, Katherine M. Hannan, Jennifer R. Devlin
This document contains additional materials and methods details, tables of antibody and primer details and supplementary data figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a9e7e51dc04791e93b78a1579b31e2
https://doi.org/10.1158/2159-8290.22530947.v1
https://doi.org/10.1158/2159-8290.22530947.v1
Autor:
Richard B. Pearson, Ross D. Hannan, Grant A. McArthur, Ricky W. Johnstone, Sean O'Brien, Denis Drygin, Jian Kang, Elaine Sanij, Gretchen Poortinga, Megan J. Bywater, Jake Shortt, Amee J. George, Pui Yee Ng, Eric Kusnadi, Carleen Cullinane, Nadine Hein, Katherine M. Hannan, Jennifer R. Devlin
This figure shows supplementary data pertinent to Figure 2 including cell death and tumour cell analysis data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7efb60b62e756d8d869c7465704dc4
https://doi.org/10.1158/2159-8290.22530956
https://doi.org/10.1158/2159-8290.22530956
Autor:
Yoon-Chi Han, Pui-Yee Ng, Luisa Shin Ogawa, Shao Ning Yang, Miao Chen, Noboru Ishiyama, Tai-An Lin, Elizabeth Buck
Publikováno v:
Cancer Research. 83:3415-3415
Mutations in BRAF and RAS are often oncogenic and lead to a constitutively active MAPK pathway that promotes aberrant cell proliferation and tumor growth. Currently approved BRAF inhibitors are selective against monomeric BRAF V600 mutants. These dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7452b4d22de18faa4a9d6580c96545a0
https://doi.org/10.1158/1538-7445.am2023-3415
https://doi.org/10.1158/1538-7445.am2023-3415
Autor:
Yoon-Chi Han, Pui Yee Ng, Ryan Schulz, Shao Ning Yang, Alana Lelo, Luisa Shin, Matthew O'Connor, Ivan Jewett, Noboru Ishiyama, Darlene Romashko, Shalabh Thakur, Andrei Salomatov, Sherri Smith, Elizabeth Buck, Christopher Roberts, Matthew Lucas, Tai-An Lin
Publikováno v:
Molecular Cancer Therapeutics. 20:P229-P229
The canonical BRAF V600E (Class I) mutation is a potent oncogene uniquely active as a RAS-independent monomer, successfully targeted by several FDA-approved inhibitors. However, these first-generation BRAF inhibitors are not active against non-canoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e795319bac3cdfa16146edd1a4fbb198
https://doi.org/10.1158/1535-7163.targ-21-p229
https://doi.org/10.1158/1535-7163.targ-21-p229
Autor:
Ross L. Levine, Chiara Conti, Lanzhu Yue, Eva Sahakian, Nathan P. Horvat, Amit Verma, John Powers, Narmin E. Amin, Afua A. Akuffo, Kenneth L. Wright, C. Gary Marshall, Pui Yee Ng, Ling Zhang, Javier Pinilla-Ibarz, Xiaozhang Zheng, John M. Koomen, Julia M.R. Billington, Zonghong Shao, Matthew Beatty, Lancia Darville, Christelle M. Colin, Pearlie K. Epling-Burnette, Eduardo M. Sotomayor, Que T. Lambert-Showers, Jennifer Y. Lee, Matthew W. Martin, Gary W. Reuther, Cem Murdun, H. Leighton Grimes, William E. Goodheart, Vasundhara Sharma
Publikováno v:
Blood
Protein acetylation is an important contributor to cancer initiation. Histone deacetylase 6 (HDAC6) controls JAK2 translation and protein stability and has been implicated in JAK2-driven diseases best exemplified by myeloproliferative neoplasms (MPNs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634ceea44a77557b60fe813516a9e8b7
https://pubmed.ncbi.nlm.nih.gov/31750881
https://pubmed.ncbi.nlm.nih.gov/31750881
Autor:
Elaine Sanij, Jake Shortt, Amee J George, Richard B. Pearson, Jian Kang, Ross D. Hannan, Gretchen Poortinga, Denis Drygin, Carleen Cullinane, Jennifer R. Devlin, Nadine Hein, Ricky W. Johnstone, Sean O'Brien, Eric P Kusnadi, Katherine M. Hannan, Megan J. Bywater, Grant A. McArthur, Pui Yee Ng
Publikováno v:
Cancer Discovery. 6:59-70
Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those driven by the proto-oncogene c-MYC characterized by elevated Pol I–mediated ribosomal rDNA transcription and mTORC1/eIF4E-driven mRNA translation. Here, we demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f80e48176daf974e69b2096925a8c1
https://doi.org/10.1158/2159-8290.cd-14-0673
https://doi.org/10.1158/2159-8290.cd-14-0673
Autor:
C. Gary Marshall, Maureen S. Lynes, Collis Alan John, Lili Yao, Kshama Doshi, Pui Yee Ng, Aleksandra Rudnitskaya, Jennifer R. Thomason, Monica A. Alvarez Morales, Xiaozhang Zheng, Matthew W. Martin, Bingsong Han, Jennifer Y. Lee, David R. Lancia, Chiara Conti
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(12)
N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827461c72e8428af478f504b9d6536c3
https://pubmed.ncbi.nlm.nih.gov/29776742
https://pubmed.ncbi.nlm.nih.gov/29776742
Autor:
Eduardo M. Sotomayor, Ross L. Levine, Narmin E. Amin, Julia M.R. Billington, Amit Verma, John Powers, Nathan P. Horvat, Zonghong Shao, Lancia Darville, Pearlie K. Epling-Burnette, Afua A. Akuffo, Kenneth P. Wright, H. Leighton Grimes, Cem Murdun, Gary C. Marshall, Vasundhara Sharma, Gary W. Reuther, Ling Zhang, Xiaozhang Zheng, Que T. Lambert-Showers, Mathew W. Martin, Jennifer Lee, Pui Yee Ng, Mathew Beatty, Lanzhu Yue, John M. Koomen, Eva Sahakian, Agni Christodoulidou, William E. Goodheart, Javier Pinilla Ibarz
Publikováno v:
Blood. 134:474-474
Introduction: Acetylated histone and non-histone proteins are pharmacologic targets for both solid and hematological cancers including myeloproliferative neoplasms (MPNs), a group of clonal hematological malignancies driven by aberrant JAK2/STAT sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f559c691cb93214f84ccd1cf335b79a3
https://doi.org/10.1182/blood-2019-127235
https://doi.org/10.1182/blood-2019-127235
Autor:
Jill C. Milne, Angela Tornblom, Jean Bemis, Jeremy S. Disch, George P. Vlasuk, Peter Elliot, Amy V. Lynch, Robert B. Perni, Pui Yee Ng, James L. Ellis, Akanksha Gupta, Christopher Oalmann, Joseph J. Nunes, J. Joshua Smith, Kristina Kriksciukaite, Michael R. Jirousek, Marie Yeager, Vipin Suri, David P. Carney, Meghan Duncan, Jeffrey Song, Siva Lavu, Thomas V. Riera, Chi B. Vu
Publikováno v:
Letters in Drug Design & Discovery. 10:793-797
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0097b909e7a83a1c2a6561804d09532
https://doi.org/10.2174/15701808113100990021
https://doi.org/10.2174/15701808113100990021
Autor:
Jake Shortt, Richard B. Pearson, Ross D. Hannan, Pui Yee Ng, Jennifer R. Devlin, Ricky W. Johnstone, Carleen Cullinane, Katherine M. Hannan, Megan J. Bywater, Grant A. McArthur
Publikováno v:
FEBS Journal. 280:5307-5316
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high proportion of human cancers, and together they form a 'super signalling' network mediating malignancy. A fundamental downstream action of this signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e77a27a2e1d02d94d92ceb830d5e5d
https://doi.org/10.1111/febs.12135
https://doi.org/10.1111/febs.12135