Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Pui-Kai Li"'
Publikováno v:
Molecules, Vol 28, Iss 7, p 3043 (2023)
The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes. They are epigenetic readers of histone a
Externí odkaz:
https://doaj.org/article/d971e40697a3416aa0a2c4a195a845ac
Autor:
Emma J. Montgomery, Enming Xing, Moray J. Campbell, Pui-Kai Li, James S. Blachly, Allan Tsung, Christopher C. Coss
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13768 (2022)
Hepatocellular carcinoma (HCC) is the predominant type of liver cancer and a leading cause of cancer-related death globally. It is also a sexually dimorphic disease with a male predominance both in HCC and in its precursors, non-alcoholic fatty liver
Externí odkaz:
https://doaj.org/article/7df34a83242d4a3fa00b8c3c520e558a
Autor:
Paula A. Agudelo-Garcia, Jessica K. De Jesus, Shante P. Williams, Michal O. Nowicki, Ennio Antonio Chiocca, Sandya Liyanarachchi, Pui-Kai Li, John J. Lannutti, Jed K. Johnson, Sean E. Lawler, Mariano S. Viapiano
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 9, Pp 831-840 (2011)
A hallmark of malignant gliomas is their ability to disperse through neural tissue, leading to long-term failure of all known therapies. Identifying new antimigratory targets could reduce glioma recurrence and improve therapeutic efficacy, but screen
Externí odkaz:
https://doaj.org/article/70e89dedea95496eaed38ddd00abd254
Autor:
Li Lin, Brian Hutzen, Pui-Kai Li, Sarah Ball, Mingxin Zuo, Stephanie DeAngelis, Elizabeth Foust, Matthew Sobo, Lauren Friedman, Deepak Bhasin, Ling Cen, Chenglong Li, Jiayuh Lin
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 39-50 (2010)
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) signaling is frequently detected in cancer, promoting its emergence as a promising target for cancer treatment. Inhibiting constitutive STAT3 signaling represents a
Externí odkaz:
https://doaj.org/article/c3a5375c5bac4a59bd50fdd833084992
Autor:
Li Lin, Brian Hutzen, Hsiu-Fang Lee, Zhengang Peng, Wenlong Wang, Chongqiang Zhao, Huey-Jen Lin, Duxin Sun, Pui-Kai Li, Chenglong Li, Hasan Korkaya, Max S Wicha, Jiayuh Lin
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82821 (2013)
STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment. Recent experimental evidence suggests ALDH-positive (ALDH(+)), or cell surface molecule CD44-positive (CD44(
Externí odkaz:
https://doaj.org/article/284652a4bed94c1faa0710b55d99ed0c
Autor:
Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinski
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e40724 (2012)
The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3) pathway is critical for promoting an oncogenic and metastatic phenotype in several types of cancer including renal cell carcinoma (RCC) and melanoma. This study desc
Externí odkaz:
https://doaj.org/article/5599ab05f7594c22bf3b3ba8343111bc
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18820 (2011)
Tumors of the central nervous system represent a major source of cancer-related deaths, with medulloblastoma and glioblastoma being the most common malignant brain tumors in children and adults respectively. While significant advances in treatment ha
Externí odkaz:
https://doaj.org/article/6b01772ee5404d378ac9fb56a32acbd7
Autor:
Jennifer R. Grandis, Daniel E. Johnson, Kusum Pandit, Naftali Kaminski, Xiaomin Chen, William E. Gooding, Raja R. Seethala, Simion Chiosea, Lin Wang, Pui-Kai Li, Jonathan P. Etter, Srinivas Rapireddy, Danith Ly, Changyou Li, Haibin Shi, Maria L. Freilino, Sonali Joyce, Nivedita Sahu, Jessica Lee, Umamaheswar Duvvuri, Jonas T. Johnson, Robert L. Ferris, Joanne I. Yeh, Seungwon Kim, Sufi M. Thomas, Malabika Sen
PDF file - 2.2MB, Modified STAT3 decoys demonstrate enhanced resistance to thermal denaturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f5870414757b94ce3c02ac424e1aa7
https://doi.org/10.1158/2159-8290.22528743.v1
https://doi.org/10.1158/2159-8290.22528743.v1
Autor:
Jennifer R. Grandis, Daniel E. Johnson, Kusum Pandit, Naftali Kaminski, Xiaomin Chen, William E. Gooding, Raja R. Seethala, Simion Chiosea, Lin Wang, Pui-Kai Li, Jonathan P. Etter, Srinivas Rapireddy, Danith Ly, Changyou Li, Haibin Shi, Maria L. Freilino, Sonali Joyce, Nivedita Sahu, Jessica Lee, Umamaheswar Duvvuri, Jonas T. Johnson, Robert L. Ferris, Joanne I. Yeh, Seungwon Kim, Sufi M. Thomas, Malabika Sen
PDF file - 1.2MB, Modified STAT3 decoys bind to pSTAT3 protein with similar affinity as the parental STAT3 decoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30539ef8faef811ec7986b2385e8d410
https://doi.org/10.1158/2159-8290.22528740.v1
https://doi.org/10.1158/2159-8290.22528740.v1
Autor:
Jennifer R. Grandis, Daniel E. Johnson, Kusum Pandit, Naftali Kaminski, Xiaomin Chen, William E. Gooding, Raja R. Seethala, Simion Chiosea, Lin Wang, Pui-Kai Li, Jonathan P. Etter, Srinivas Rapireddy, Danith Ly, Changyou Li, Haibin Shi, Maria L. Freilino, Sonali Joyce, Nivedita Sahu, Jessica Lee, Umamaheswar Duvvuri, Jonas T. Johnson, Robert L. Ferris, Joanne I. Yeh, Seungwon Kim, Sufi M. Thomas, Malabika Sen
PDF file - 107K, Systemic delivery of cyclic STAT3 decoy does not affect total or pSTAT3 expression levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2098d043169646d758cfedaf2f14b31a
https://doi.org/10.1158/2159-8290.22528731
https://doi.org/10.1158/2159-8290.22528731