Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models

Autor: Paula Olaizola, Pui Yuen Lee-Law, Maite G. Fernandez-Barrena, Laura Alvarez, Massimiliano Cadamuro, Mikel Azkargorta, Colm J. O’Rourke, Francisco J. Caballero-Camino, Irene Olaizola, Rocio I.R. Macias, Jose J.G. Marin, Marina Serrano-Maciá, Maria L. Martinez-Chantar, Matias A. Avila, Patricia Aspichueta, Diego F. Calvisi, Matthias Evert, Luca Fabris, Rui E. Castro, Felix Elortza, Jesper B. Andersen, Luis Bujanda, Pedro M. Rodrigues, Maria J. Perugorria, Jesus M. Banales

Publikováno v: Olaizola, P, Lee-Law, P Y, Fernandez-Barrena, M G, Alvarez, L, Cadamuro, M, Azkargorta, M, O'Rourke, C J, Caballero-Camino, F J, Olaizola, I, Macias, R I R, Marin, J J G, Serrano-Maciá, M, Martinez-Chantar, M L, Avila, M A, Aspichueta, P, Calvisi, D F, Evert, M, Fabris, L, Castro, R E, Elortza, F, Andersen, J B, Bujanda, L, Rodrigues, P M, Perugorria, M J & Banales, J M 2022, ' Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models ', Journal of Hepatology, vol. 77, no. 1, pp. 177-190 . https://doi.org/10.1016/j.jhep.2022.02.007
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[EN] BACKGROUND & AIMS: Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications (PTMs), including NEDDylation, result in abnormal protein dynamics,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc951961d3c4bc25aa43db66243e451
https://doi.org/10.1016/j.jhep.2022.02.007

178 - THERAPEUTIC POTENTIAL OF TARGETING PROTEIN HYPER- SUMOYLATION IN CHOLANGIOCARCINOMA

Autor: Paula Olaizola, Irene Olaizola, Marta Fernández de Ara, Maite G. Fernández-Barrena, Laura Alvarez, Mikel Azkargorta, Colm J. O’Rourke, Pui-Yuen Lee-Law, Luiz Miguel Nova-Camacho, Jose J.G. Marin, Maria L. Martínez-Chantar, Matias A. Avila, Patricia Aspichueta, Felix Elortza, Jesper B. Andersen, Luis Bujanda, Pedro M. Rodrigues, Maria J. Perugorria, Jesus M. Bañales

Publikováno v: Gastroenterología y Hepatología. 46:S210

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56d5119d22e5eb8583bd7f5d1d16602f
https://doi.org/10.1016/s0210-5705(23)00310-2