Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pui Yeng Lam"'
Autor:
Duy Pham, Xiao Tan, Brad Balderson, Jun Xu, Laura F. Grice, Sohye Yoon, Emily F. Willis, Minh Tran, Pui Yeng Lam, Arti Raghubar, Priyakshi Kalita-de Croft, Sunil Lakhani, Jana Vukovic, Marc J. Ruitenberg, Quan H. Nguyen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Spatial transcriptomics (ST) technologies generate multiple data types from biological samples, namely gene expression, physical distance between data points, and/or tissue morphology. Here we developed three computational-statistical algori
Externí odkaz:
https://doaj.org/article/90386dc9c14b4450ad2ce44635d342ec
Autor:
Arti M. Raghubar, Duy T. Pham, Xiao Tan, Laura F. Grice, Joanna Crawford, Pui Yeng Lam, Stacey B. Andersen, Sohye Yoon, Siok Min Teoh, Nicholas A. Matigian, Anne Stewart, Leo Francis, Monica S. Y. Ng, Helen G. Healy, Alexander N. Combes, Andrew J. Kassianos, Quan Nguyen, Andrew J. Mallett
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Available transcriptomes of the mammalian kidney provide limited information on the spatial interplay between different functional nephron structures due to the required dissociation of tissue with traditional transcriptome-based methodologies. A dee
Externí odkaz:
https://doaj.org/article/f9f48ceb22244753811383cd23084a84
Autor:
Daniel Kerage, Megan S. F. Soon, Brianna L. Doff, Takumi Kobayashi, Michael D. Nissen, Pui Yeng Lam, Graham R. Leggatt, Stephen R. Mattarollo
Publikováno v:
OncoImmunology, Vol 7, Iss 10 (2018)
Immunomodulatory therapies can effectively control haematological malignancies. Previously we reported the effectiveness of combination immunotherapies that centre on 4-1BB-targeted co-stimulation of CD8 + T cells, particularly when simultaneously ha
Externí odkaz:
https://doaj.org/article/6c4f4e3291b5469c93c248b83ded3645
Autor:
Sara J. McKee, Zewen K. Tuong, Takumi Kobayashi, Brianna L. Doff, Megan SF Soon, Michael Nissen, Pui Yeng Lam, Colm Keane, Frank Vari, Davide Moi, Roberta Mazzieri, Graham Leggatt, Maher K. Gandhi, Stephen R. Mattarollo
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Monocytosis is considered a poor prognostic factor for many cancers, including B cell lymphomas. The mechanisms by which different monocyte subsets support the growth of lymphoma is poorly understood. Using a pre-clinical mouse model of B cell non-Ho
Externí odkaz:
https://doaj.org/article/5598b069cc7b452b8f1ee3c736e64cbf
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers. They predom
Externí odkaz:
https://doaj.org/article/11b837f892124786bd2b7cca2605e9c2
Autor:
Stephen R. Mattarollo, Ranjeny Thomas, Graham Leggatt, Riccardo Dolcetti, Bijun Zeng, Megan Soon, Takumi Kobayashi, Pui Yeng Lam
Invariant natural killer T (iNKT) cells are a subset of lymphocytes with immune regulatory activity. Their ability to bridge the innate and adaptive immune systems has been studied using the glycolipid ligand α-galactosylceramide (αGC). To better h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e79093595c6398c9ca3098a315f12b
https://doi.org/10.1158/2326-6066.c.6549799.v1
https://doi.org/10.1158/2326-6066.c.6549799.v1
Autor:
Stephen R. Mattarollo, Ranjeny Thomas, Graham Leggatt, Riccardo Dolcetti, Bijun Zeng, Megan Soon, Takumi Kobayashi, Pui Yeng Lam
Supplementary Figures 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e49f7fecfe92c18cbd0058ae26fcae8
https://doi.org/10.1158/2326-6066.22542109
https://doi.org/10.1158/2326-6066.22542109
Autor:
Tuan Vo, Kahli Jones, Sohye Yoon, Pui Yeng Lam, Yung-Ching Kao, Chenhao Zhou, P. Prakrithi, Joanna Crawford, Shaun Walters, Ishaan Gupta, H. Peter Soyer, Kiarash Khosrotehrani, Mitchell S. Stark, Quan Nguyen
AbtractsApplying spatial transcriptomics (ST) to explore a vast amount of formalin-fixed paraffin-embedded (FFPE) archival cancer tissues has been highly challenging due to several critical technical issues. In this work, we optimised ST protocols to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74132c88a9206007a7a46ff8871b0563
https://doi.org/10.1101/2023.02.11.527941
https://doi.org/10.1101/2023.02.11.527941
Autor:
Duy Pham, Pui Yeng Lam, Siok Min Teoh, Stacey B. Andersen, Alexander N. Combes, Anne Stewart, Helen Healy, Andrew Mallett, Laura F. Grice, Quan Nguyen, Andrew J. Kassianos, L. Francis, Joanna Crawford, Sohye Yoon, Monica S.Y. Ng, Arti Raghubar, Samuel Holland, Xiao Tan
Understanding the molecular mechanisms underlying mammalian kidney function requires transcriptome profiling of the interplay between cells comprising nephron segments. Traditional transcriptomics requires cell dissociation, resulting in loss of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f9a3034f94be4bbc30dd1b5724fe95d
https://doi.org/10.1101/2020.09.29.317917
https://doi.org/10.1101/2020.09.29.317917
Autor:
Arti Raghubar, Xiao Tan, Jun Xu, Jana Vukovic, Marc J. Ruitenberg, Quan Nguyen, Laura F. Grice, Duy Pham, Pui Yeng Lam
Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and tissue morphology to the genome-wide transcriptional profile of cells in an undissociated tissue. Integrating these three types of data creates a vast potential fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c908ec3abbe1e3a410e727fd760808d
https://doi.org/10.1101/2020.05.31.125658
https://doi.org/10.1101/2020.05.31.125658