Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Pui Man Hoi"'
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-35 (2024)
Abstract Background Overactive bladder (OAB) presents a high prevalence of 16–18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and h
Externí odkaz:
https://doaj.org/article/08d0abfbe5bc4a409036b329b322adc2
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1272 (2024)
Background: T-006, a novel neuroprotective derivative of tetramethylpyrazine (TMP), exhibits multifunctional neuroprotective properties. T-006 has been shown to improve neurological and behavioral functions in animal models of ischemic stroke and neu
Externí odkaz:
https://doaj.org/article/0796b168a88b46e3a6cc0ba5af13157f
Autor:
Xinhua Zhou, Zeyu Zhu, Shaoming Kuang, Kaipeng Huang, Yueping Li, Yuqiang Wang, Haiyun Chen, Maggie Pui Man Hoi, Benhong Xu, Xifei Yang, Zaijun Zhang
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1005 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with age. A wealth of evidence indicates that the amyloid β (Aβ) aggregates result from dyshomeostasis between Aβ production and clearance, which plays a pivotal role in the pat
Externí odkaz:
https://doaj.org/article/56ed11ec5ac8478c8f4180de06b0412a
Autor:
Qian Yue, Maggie Pui Man Hoi
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 9, Pp 1890-1902 (2023)
Blood-brain barrier disruption occurs in the early stages of Alzheimer’s disease. Recent studies indicate a link between blood-brain barrier dysfunction and cognitive decline and might accelerate Alzheimer’s disease progression. Astrocytes are th
Externí odkaz:
https://doaj.org/article/06ad564efcde4ae29c0a681e0f143cbd
Autor:
Xinhua Zhou, Kaipeng Huang, Yuqiang Wang, Zaijun Zhang, Yingying Liu, Qinghua Hou, Xifei Yang, Maggie Pui Man Hoi
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The pathophysiology of Alzheimer’s disease (AD) is multifactorial with characteristic extracellular accumulation of amyloid-beta (Aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. Development of disease-modifying treatment
Externí odkaz:
https://doaj.org/article/9ce91f4645dc48f3a0b250723e80eaf6
Autor:
Wei Liu, Jian Zheng, Xiaohu Ren, Yuxuan Xie, Dafeng Lin, Peimao Li, Yuan Lv, Maggie Pui Man Hoi, Yanfang Zhang, Jianjun Liu
Publikováno v:
Journal of Occupational Medicine and Toxicology, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Trichloroethylene (TCE) hypersensitivity syndrome (THS) is a dose-independent and potentially life-threatening disease. In this study, we sought to identify THS-related miRNAs and evaluate its potential clinical value. Methods Ser
Externí odkaz:
https://doaj.org/article/2fd2ed107ed04999a1234c6c79f8414b
Autor:
Chen Zhao, Hio-Tong Kam, Yan Chen, Guiyi Gong, Maggie Pui-Man Hoi, Krystyna Skalicka-Woźniak, Alberto Carlos Pires Dias, Simon Ming-Yuen Lee
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Crocetin and crocin are two important carotenoids isolated from saffron (Crocus sativus L.), which have been used as natural biomedicines with beneficial effects for improving the suboptimal health status associated with abnormal angiogenesis. Howeve
Externí odkaz:
https://doaj.org/article/cda241c2b344422fb62a280329ccfd86
Publikováno v:
Molecules, Vol 27, Iss 4, p 1206 (2022)
Dysfunction of the blood–brain barrier (BBB) is involved in the pathogenesis of many cerebral diseases. Oxidative stress and inflammation are contributing factors for BBB injury. Piceatannol, a natural ingredient found in various plants, such as gr
Externí odkaz:
https://doaj.org/article/d700493bafd940b0bc3c1d35be854909
Autor:
Wei Liu, Kaiwu He, Desheng Wu, Li Zhou, Guowei Li, Zequn Lin, Xifei Yang, Jianjun Liu, Maggie Pui Man Hoi
Publikováno v:
Molecules, Vol 27, Iss 4, p 1281 (2022)
Discovering new and effective drugs for the treatment of Alzheimer’s disease (AD) is a major clinical challenge. This study focuses on chemical modulation of the gut microbiome in an established murine AD model. We used the 16S rDNA sequencing tech
Externí odkaz:
https://doaj.org/article/4318451ca9f54737bd4a3aa334bc7e93
Autor:
Chuwen Li, Tongkai Chen, Hefeng Zhou, Chao Zhang, Yu Feng, Fan Tang, Maggie Pui-Man Hoi, Chengwei He, Ying Zheng, Simon Ming-Yuen Lee
Publikováno v:
Cellular Physiology and Biochemistry, Vol 47, Iss 5, Pp 1769-1784 (2018)
Background/Aims: In the present study, we investigated whether schisantherin A (StA) had anti-inflammatory effects under neuroinflammatory conditions. Methods: The effects of StA and its underlying mechanisms were examined in lipopolysaccharide (LPS)
Externí odkaz:
https://doaj.org/article/ed9b9b3c46764af987eb17bde1a707a7