Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Pui Kei Wu"'
Autor:
William E. Antholine, Jeannette Vasquez-Vivar, Brendan J. Quirk, Harry T. Whelan, Pui Kei Wu, Jong-In Park, Charles R. Myers
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1143 (2019)
In a previous study on chromate toxicity, an increase in the 2Fe2S electron paramagnetic resonance (EPR) signal from mitochondria was found upon addition of chromate to human bronchial epithelial cells and bovine airway tissue ex vivo. This study was
Externí odkaz:
https://doaj.org/article/43c08b7a4e72403fa641d8177a2a36ce
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Genetic alternation of REarranged during Transfection (RET) that leads to constitutive RET activation is a crucial etiological factor for thyroid cancer. RET is known to regulate mitochondrial processes, although the underlying molecular mec
Externí odkaz:
https://doaj.org/article/49d45021c2924d2d9dc11e4debc940e3
Publikováno v:
Cancer Letters. 502:25-33
Therapy resistance to a selective B-Raf inhibitor (BRAFi) poses a challenge in treating patients with BRAF-mutant melanomas. Here, we report that RNA interference of mortalin (HSPA9/GRP75), a mitochondrial molecular chaperone often upregulated and mi
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13187
International Journal of Molecular Sciences, Vol 22, Iss 13187, p 13187 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 13187, p 13187 (2021)
Deoxyhypusine synthase (DHPS) catalyzes the first step of hypusination of the elongation translation factor 5A (eIF5A), and these two proteins have an exclusive enzyme–substrate relationship. Here we demonstrate that DHPS has a role independent of
Autor:
Seung-Keun Hong, Jason E. Gestwicki, Jong-In Park, Susan Tsai, Hao Shao, Dmytro Starenki, Pui Kei Wu, Kiyoko Oshima
Publikováno v:
Oncogene
Oncogene, vol 39, iss 21
Oncogene, vol 39, iss 21
The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin depletion can selectively induce death of immortalized normal fibroblasts IMR90E1A when combined
Publikováno v:
Cancer Lett
Therapy resistance to a selective B-Raf inhibitor (BRAFi) poses a challenge in treating patients with BRAF-mutant melanomas. Here, we report that RNA interference of mortalin (HSPA9/GRP75), a mitochondrial molecular chaperone often upregulated and mi
Autor:
Pui-Kei, Wu, Seung-Keun, Hong, Wenjing, Chen, Andrew E, Becker, Rebekah L, Gundry, Chien-Wei, Lin, Hao, Shao, Jason E, Gestwicki, Jong-In, Park
Publikováno v:
Sci Signal
Mortalin [also known as heat shock protein family A (Hsp70) member 9 (HSPA9) or glucose-regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often upregulated and mislocalized in tumors with abnormal activation of the kinases
Autor:
Jason E. Gestwicki, Hao Shao, Rebekah L. Gundry, Jong-In Park, Pui Kei Wu, Andrew E. Becker, Seung-Keun Hong, Wenjing Chen, Chien-Wei Lin
Publikováno v:
Science Signaling. 13
Mortalin [also known as heat shock protein family A (HSP70) member 9 (HSPA9) or glucose-regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often up-regulated and mislocalized in tumors with abnormal activation of the kinases
Publikováno v:
Cellular Signalling. 42:11-20
In addition to its conventional role for cell proliferation and survival, the Raf/MEK/Extracellular signal-regulated kinase (ERK) pathway can also induce growth arrest and death responses, if aberrantly activated. Here, we determined a molecular basi
Publikováno v:
Cancer Biology & Therapy. 18:473-483
Although the FDA-approved receptor tyrosine kinases inhibitors, vandetanib and cabozantinib, are used to treat surgically inoperable progressive medullary thyroid carcinoma (MTC), not all patients are responsive while the disease sometimes progresses