Zobrazeno 1 - 10 of 217 pro vyhledávání: '"Pui Kai LI"'
1
Akademický článek
Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
Autor: Yaogang Zhong, Feng Geng, Logan Mazik, Xinmin Yin, Aline Paixao Becker, Shabber Mohammed, Huali Su, Enming Xing, Yongjun Kou, Cheng-Yao Chiang, Yunzhou Fan, Yongchen Guo, Qiang Wang, Pui-Kai Li, Xiaokui Mo, Etienne Lefai, Liqing He, Xiaolin Cheng, Xiang Zhang, Arnab Chakravarti, Deliang Guo
Publikováno v: Cell Reports Medicine, Vol 5, Iss 9, Pp 101706- (2024)
Summary: Antipsychotic drugs have been shown to have antitumor effects but have had limited potency in the clinic. Here, we unveil that pimozide inhibits lysosome hydrolytic function to suppress fatty acid and cholesterol release in glioblastoma (GBM
Externí odkaz: https://doaj.org/article/19761d521bc9430d9999b8b10ef7bd69
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2
Akademický článek
BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Autor: Kenneth K. W. To, Enming Xing, Ross C. Larue, Pui-Kai Li
Publikováno v: Molecules, Vol 28, Iss 7, p 3043 (2023)
The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes. They are epigenetic readers of histone a
Externí odkaz: https://doaj.org/article/d971e40697a3416aa0a2c4a195a845ac
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