Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Pudzianowski AT"'
Autor:
Celia D’Arienzo, Ananta Karmakar, Marta Dabros, Michael Galella, Jingwu Duan, John S. Sack, Dhanya Kumar Raut, David S. Weinstein, Andrew T. Pudzianowski, Ding-Ren Shen, Sylwia Stachura, Joel C. Barrish, Arun Kumar Gupta, Huadong Sun, William R. Foster, Javed Khan, Melissa Yarde, Dan Camac, Lauren Haque, Qihong Zhao, Dauh-Rurng Wu, Carolyn A. Weigelt, Faye Wang, Percy H. Carter, Luisa Salter-Cid, Hemalatha Hemagiri, Jenny Xie, T. G. Murali Dhar, Zhonghui Lu, Virna Borowski, Hua Gong, John E. Somerville
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:85-93
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists. However, a majority of these compounds showed potent activity against pregnane X receptor (
Autor:
Gong, Hua, Weinstein, David S., Lu, Zhonghui, Duan, James J.-W., Stachura, Sylwia, Haque, Lauren, Karmakar, Ananta, Hemagiri, Hemalatha, Raut, Dhanya Kumar, Gupta, Arun Kumar, Khan, Javed, Camac, Dan, Sack, John S., Pudzianowski, Andrew, Wu, Dauh-Rurng, Yarde, Melissa, Shen, Ding-Ren, Borowski, Virna, Xie, Jenny H., Sun, Huadong, D'Arienzo, Celia, Dabros, Marta, Galella, Michael A., Wang, Faye, Weigelt, Carolyn A., Zhao, Qihong, Foster, William, Somerville, John E., Salter-Cid, Luisa M., Barrish, Joel C., Carter, Percy H., Dhar, T.G. Murali
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 January 2018 28(2):85-93
Autor:
Animesh Goswami, Feng Qiu, Carl P. Decicco, Andrew T. Pudzianowski, Quentin Michaudel, Adrienne A. Tymiak, Patrick Y.S. Lam, Samuel J. Bonacorsi, Yingru Zhang, Benjamin P. Vokits, Bei Wang, Brad D. Maxwell, Bang-Chi Chen, Ronald L. Hanson, Jun Dai, Arvind Mathur, Dauh-Rurng Wu, Scott A. Shaw, W. Griffith Humphreys, Shun Su, Phil S. Baran, Janet Caceres Cortes, Balu Balasubramanian, Ruth R. Wexler, Zhiwei Guo, Rulin Zhao, Dawn Sun, Wenying Li, Li Peng, Kevin Cao
Publikováno v:
The Journal of Organic Chemistry. 80:7019-7032
Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and thus inhibit platelet activation. However, gaining an understanding of patient response has been limited due to imprecise und
Autor:
Stanisław Pudzianowski, Magdalena Szalewska, Natalia Pochroń, Leszek Szalewski, Janusz Borowicz, Marta Lupa, Andrzej Bożyk
Publikováno v:
Polish Journal of Public Health. 124:73-76
Introduction. The joint hypermobility syndrome is a connective tissue disorder affecting the entire organism. The symptoms include laxity of joint-stabilizing capsules and ligaments, excessive joint mobility and other accompanying symptoms. Some symp
Autor:
Joseph Yanchunas, Eddie C.-K. Liu, Christine Huang, S. M. Seiler, Yan Shi, Ying Wang, Karnail S. Atwal, Thomas E. Steinbacher, Doree F. Sitkoff, Andrew T. Pudzianowski, William A. Schumacher, Karen S. Hartl, Sharon N. Bisaha, Chi Li, Stephen P. O'connor, Kevin Kish, Mengxiao Shi, Philip D. Stein, Herbert E. Klei, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6882-6889
We report the design and synthesis of a novel class of N,N'-disubstituted aroylguanidine-based lactam derivatives as potent and orally active FXa inhibitors. The structure-activity relationships (SAR) investigation led to the discovery of the nicotin
Publikováno v:
International Journal of Quantum Chemistry. 18:223-244
Potential energy surfaces for the SS1 and SS2 attack of water on protonated benzene oxide and benzene diol epoxide have been calculated using the mindo/3 method. Calculated enthalpies of activation are consistent with the known experimental behavior
Autor:
Pudzianowski, Andrew T.
Publikováno v:
Journal of Chemical Physics; 5/22/1995, Vol. 102 Issue 20, p8029, 11p
Autor:
Jack Z. Gougoutas, Karen S. Hartl, R. Michael Lawrence, Doree F. Sitkoff, Gregory S. Bisacchi, Steven M. Seiler, Andrew T. Pudzianowski, William A. Schumacher, Philip D. Stein, Eddie C.-K. Liu, Thomas E. Steinbacher, Zhaoxiao Zhang, James C. Sutton
Publikováno v:
Letters in Drug Design & Discovery. 2:625-630
Autor:
Bruce M. Rankin, William J. Pitts, William J. Metzler, Kenneth J. Leavitt, Andrew T. Pudzianowski, Wayne Vaccaro, Richard Liu, Patricia A. McDonnell, Joseph Barbosa, Soong-Hoon Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1101-1106
Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13.
Autor:
Andrew T. Pudzianowski
Publikováno v:
International Journal of Quantum Chemistry. 88:147-153
A methyl diester protoporphyrin IX complex with ferric ion in a low-spin doublet state and with ethyl sulfide as a constant axial ligand, is proposed as a model system for examining cytochrome P-450 Fe-binding inhibitors, e.g., imidazoles and pyridin