Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Puay-Wah Phuan"'
Autor:
Onur Cil, Puay-Wah Phuan, Sujin Lee, Joseph Tan, Peter M. Haggie, Marc H. Levin, Liang Sun, Jay R. Thiagarajah, Tonghui Ma, Alan S. Verkman
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 3, Pp 317-327 (2016)
Background & Aims: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel i
Externí odkaz:
https://doaj.org/article/e1ed29e354e3480ab8fec86c297f2023
Autor:
Mark J. Kurth, Peter M. Haggie, Marina E. Shatskikh, Julia Y. Lu, Jung-Ho Son, Alan S. Verkman, Amber A. Rivera, Joseph-Anthony Tan, Jie S. Zhu, Puay-Wah Phuan
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 29, iss 16
Bioorg Med Chem Lett
Bioorg Med Chem Lett
Pendrin is a transmembrane chloride/anion antiporter that is strongly upregulated in the airways in rhinoviral infection, asthma, cystic fibrosis and chronic rhinosinusitis. Based on its role in the regulation of airway surface liquid depth, pendrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5b365bb1f538164643be9aacb68beb
https://doi.org/10.1016/j.bmcl.2019.07.003
https://doi.org/10.1016/j.bmcl.2019.07.003
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106824 (2014)
Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and inflammation resulti
Externí odkaz:
https://doaj.org/article/83f3d25240314191980d6571390a9f9d
Autor:
Puay-Wah Phuan, Alan S. Verkman, Jie S. Zhu, Jung-Ho Son, Ka Yi Tsui, Peter M. Haggie, Soren Lipman, Mark J. Kurth, Amy Cheung, Dean J. Tantillo
Publikováno v:
Eur J Med Chem
We previously identified a spiro [piperidine-4,1-pyrido [3,4-b]indole] class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957bd2600c5dd46874441017af9e5bc3
https://escholarship.org/uc/item/2jt1m0z8
https://escholarship.org/uc/item/2jt1m0z8
Publikováno v:
Neuropharmacology
Pathogenesis in seropositive neuromyelitis optica spectrum disorders (herein called NMO) involves binding of IgG1 autoantibodies to aquaporin-4 (AQP4) on astrocytes in the central nervous system, which initiates complement and cellular injury. We pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defddbc39525727084cff39762b331ff
https://escholarship.org/uc/item/4s64g6bg
https://escholarship.org/uc/item/4s64g6bg
Autor:
Misol Ahn, Sina Ghaemmaghami, Yong Huang, Puay-Wah Phuan, Barnaby C H May, Kurt Giles, Stephen J DeArmond, Stanley B Prusiner
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39112 (2012)
The lipophilic cationic compound quinacrine has been used as an antimalarial drug for over 75 years but its pharmacokinetic profile is limited. Here, we report on the pharmacokinetic properties of quinacrine in mice. Following an oral dose of 40 mg/k
Externí odkaz:
https://doaj.org/article/b1378581b9864925bf5d24e3b527f0f3
Autor:
Peter M. Haggie, Walter E. Finkbeiner, Joseph-Anthony Tan, Alan S. Verkman, Dennis W. Nielson, Jung-Ho Son, Luis J. V. Galietta, Mark J. Kurth, Lorna Zlock, Puay-Wah Phuan, Ilaria Musante, Clarabella J. Li
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, vol 17, iss 5
Background Current modulator therapies for some cystic fibrosis-causing CFTR mutants, including N1303K, have limited efficacy. We provide evidence here to support combination potentiator (co-potentiator) therapy for mutant CFTRs that are poorly respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff281dd2963975887cc2ef3535c3e964
https://doi.org/10.1016/j.jcf.2018.05.010
https://doi.org/10.1016/j.jcf.2018.05.010
Akademický článek
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Autor:
Elena Diez-Cecilia, Luis J. V. Galietta, Sujin Lee, Puay-Wah Phuan, Onur Cil, Sarah E Levy, Marc O. Anderson, Loretta Ferrera, Amanda L. Reggi, Alannah C Moises, Alan S. Verkman, Eric C. Truong
Publikováno v:
Journal of Medicinal Chemistry. 60:4626-4635
Transmembrane protein 16A (TMEM16A), also called anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian cells, including epithelia, vascular smooth muscle tissue, electrically excitable cells, and some tumors. TMEM16A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b691ef009cb957673a0f23c46b0d57
https://doi.org/10.1021/acs.jmedchem.7b00020
https://doi.org/10.1021/acs.jmedchem.7b00020
Autor:
Alan S. Verkman, Amber A. Rivera, Lorna Zlock, Dennis W. Nielson, Puay-Wah Phuan, Walter E. Finkbeiner, Peter M. Haggie, Joseph-Anthony Tan
Publikováno v:
Scientific Reports
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64b46f7be6481fe2a050f58427d89b7
https://pubmed.ncbi.nlm.nih.gov/31776420
https://pubmed.ncbi.nlm.nih.gov/31776420