Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pu-Ping Lu"'
Autor:
Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14930-14941
The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
https://doi.org/10.1021/acs.jmedchem.1c01067
https://doi.org/10.1021/acs.jmedchem.1c01067
Autor:
A Kennedy, Aaron C. Hinken, William F. Browne, Kwan Leung, Matthew Tomlinson, Bradley P Morgan, James J. Hartman, Pu-Ping Lu, Gustave Bergnes, Fady I. Malik, David J. Morgans, Alexander Muci, David Marquez, Marc Garard, Ion Suehiro, Scott Collibee, Kenneth Lee, Donghong Xu, Alan J. Russell, Julia Schaletzky, Raja Kawas, Darren Hwee
Publikováno v:
ACS Medicinal Chemistry Letters
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1cd746965443b1eee2a4f71ea7923b
http://europepmc.org/articles/PMC5900333
http://europepmc.org/articles/PMC5900333
Autor:
Collibee, Scott E., Bergnes, Gustave, Chihyuan Chuang, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R., Kevin Lu, Pu-Ping Lu, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wenyue Wang, Warrington, Jeffrey, Bing Yao, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia
Publikováno v:
Journal of Medicinal Chemistry; 10/28/2021, Vol. 64 Issue 20, p14930-14941, 12p
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application
Autor:
Pu-Ping Lu, Fady I. Malik, Bradley P. Morgan, Anne Houdusse, James J. Hartman, Edward G. Barrett, Karin Rudolph, Enrico A. Stura, Grace Chuang, Xiangping Qian, Virginie Ropars, Sheila Clancy, Christopher Royer, Serena Sirigu, Xi Wang, Vicente J. Planelles-Herrero
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Direct inhibition of smooth muscle myosin (SMM) is a potential means to treat hypercontractile smooth muscle diseases. The selective inhibitor CK-2018571 prevents strong binding to actin and promotes muscle relaxation in vitro and in vivo. The crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af322f90158835df4ba025977e604fc7
https://doi.org/10.1073/pnas.1609342113
https://doi.org/10.1073/pnas.1609342113
Autor:
James J. Hartman, David Ernest Clarke, Hector P. Rodriguez, Richard Hansen, Fady I. Malik, Bradley P. Morgan, Daniel L. Albertus, Michael M. Chen, Raja Kawas, William F. Browne, Khalil G. Saikali, Vipin Vijayakumar, David Marquez, Aaron C. Hinken, Alexander Muci, Scott Collibee, Alan J. Russell, Julia Schaletzky, Pu Ping Lu, Kenneth Lee, Marc Garard, David J. Morgans, Guillermo Godinez, Lena Driscoll, Zhiheng Jia, Dennis R. Claflin
Publikováno v:
Nature Medicine. 18:452-455
Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission. We developed a small-molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a15c06980cff853cda6d8b7c025847
https://doi.org/10.1038/nm.2618
https://doi.org/10.1038/nm.2618
Autor:
Katjuša Brejc, Jeffrey T. Finer, Maria Pokrovskii, David R. Cox, Daniel W. Pierce, Marc Garard, Ramesh Baliga, Congrong Niu, Todd Tochimoto, Kathleen A. Elias, Guillermo Godinez, Stephen F. Vatner, You Tang Shen, Roman Sakowicz, Bradley P. Morgan, Sandra H. Sueoka, Pu Ping Lu, Fady I. Malik, Tatsuo Katori, Alexander Muci, David Lenzi, David J. Morgans, Corey Valdez, Sheila Sylvester, Kenneth Lee, Xiangping Qian, Ion Suehiro, Erica Kraynack, Raja Kawas, David A. Kass, James J. Hartman, Hector P. Rodriguez, Robert L. Anderson, Wenyue Wang
Publikováno v:
Science. 331:1439-1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b655534b7d4dbf40b4a85dea7dd873d
https://doi.org/10.1126/science.1200113
https://doi.org/10.1126/science.1200113
Autor:
Todd Tochimoto, Zhengping Wang, Erica Kraynack, Xiangping Qian, Sheila Sylvester, Ion Suehiro, Alexander Muci, Hong Jiang, S. Corey Valdez, Adam Lewis Tomasi, Smith Whitney W, Kenneth Lee, Robert F. Anderson, Marc Garard, James J. Hartman, Donghong Xu, Hector M. Rodriguez, Guillermo Godinez, Sandra H. Sueoka, Pu-Ping Lu, Scott Collibee, Fady I. Malik, Wenyue Wang, Raja Kawas, Bradley P. Morgan, Nebojsa Djordjevic, Kathleen A. Elias, David J. Morgans
Publikováno v:
ACS Medicinal Chemistry Letters. 1:472-477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fa6e36712323135868eb9a2d577637
https://doi.org/10.1021/ml100138q
https://doi.org/10.1021/ml100138q
Autor:
Keigo Gohda, Jean-Yves Sancéau, Sandra W. Cowan-Jacob, Philippe Chemla, Lars Prade, Raymonde Fonne-Pfister, Stephen Hanessian, Pu-Ping Lu
Publikováno v:
Angewandte Chemie. 111:3353-3356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d014af11d22f5b375ed8145660a1c9
https://doi.org/10.1002/(sici)1521-3757(19991102)111:21<3353::aid-ange3353>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19991102)111:21<3353::aid-ange3353>3.0.co
Autor:
Lars Prade, Raymonde Fonne-Pfister, Stephen Hanessian, Keigo Gohda, Jean-Yves Sancéau, Philippe Chemla, Pu-Ping Lu, Sandra W. Cowan-Jacob
Publikováno v:
Angewandte Chemie International Edition. 38:3159-3162
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C3 chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate–enzyme complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e12f687c2bc13f62dff9ffa645fceb
https://doi.org/10.1002/(sici)1521-3773(19991102)38:21<3159::aid-anie3159>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19991102)38:21<3159::aid-anie3159>3.0.co
Publikováno v:
Journal of the American Chemical Society. 120:13296-13300
The reaction of 2-(1,2-trans-glycopyranosyloxy)-3-methoxypyridines (MOP glycosides) with phosphoric acid leads to the corresponding 1,2-cis-1-phosphates in good yield and excellent stereoselectivity. 1-Phosphate esters of α-d-glucopyranose, α-d-gal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::808bea849ef77a04ce938dc549455554
https://doi.org/10.1021/ja982783i
https://doi.org/10.1021/ja982783i