Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pu-Guang Chen"'
Autor:
Zhi-Hua Huang, Zhan-Yi Sun, Yue Gao, Pu-Guang Chen, Yan-Fang Liu, Yong-Xiang Chen, Yan-Mei Li
Publikováno v:
Vaccines, Vol 2, Iss 3, Pp 549-562 (2014)
Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-
Externí odkaz:
https://doaj.org/article/76d4864505c5492384b7cf6738fdbdc9
Autor:
Yan-Mei Li, Jun-Jun Wu, Rebecca L. Davis, Pu-Guang Chen, Bo-Dou Zhang, Guanyu Wang, Hong-Guo Hu, Wen-Hao Li
Publikováno v:
ChemBioChem. 21:1150-1154
The activation of toll-like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchab
Autor:
Zhuting Hu, Donna Neuberg, Rebecca L. Holden, Catherine J. Wu, Nir Hacohen, Oriol Olive, Nicholas L. Truex, Bin-You Wang, Pu-Guang Chen, Bradley L. Pentelute, Patrick A. Ott, Stephanie Hanna, Keerthi Shetty, Derin B. Keskin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
High-throughput genome sequencing and computation have enabled rapid identification of targets for personalized medicine, including cancer vaccines. Synthetic peptides are an established mode of cancer vaccine delivery, but generating the peptides fo
Autor:
Pu-Guang Chen, Yu-Qing Liu, Qian-Qian Li, Na Gao, Yun-Yi Luo, Ting-Ting Chu, Yan-Mei Li, Yong-Xiang Chen
Publikováno v:
Chemical communications (Cambridge, England). 56(40)
Herein, we have successfully semi-synthesized a TDP-43 prion-like domain with Ser404 phosphorylation. We have demonstrated that Ser404 phosphorylation could accelerate the amyloid aggregation of the TDP-43 prion-like domain and aggravate its cytotoxi
Autor:
Jun-Jun Wu, Yan-Mei Li, Bo-Dou Zhang, Qian-Qian Li, Pu-Guang Chen, Lang Zhao, Yong-Xiang Chen, Hong-Guo Hu, Wen-Hao Li, Yufen Zhao
Publikováno v:
Chemical Communications. 54:9655-9658
Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to
Autor:
Pu-Guang Chen1, Zhi-Hua Huang1, Zhan-Yi Sun1, Yue Gao1, Yan-Fang Liu1, Lei Shi1, Yong-Xiang Chen1, Yu-Fen Zhao1, Yan-Mei Li1 liym@mail.tsinghua.edu.cn
Publikováno v:
Pure & Applied Chemistry. Jul2017, Vol. 89 Issue 7, p931-939. 9p. 1 Diagram, 1 Chart, 4 Graphs.
Autor:
Bo-Dou Zhang, Yufen Zhao, Yong-Xiang Chen, Jun-Jun Wu, Yan-Mei Li, Zhan-Yi Sun, Pu-Guang Chen, Lei Shi, Yan-Fang Liu
Publikováno v:
ChemBioChem. 18:1721-1729
Immunotherapy has become one of the most promising therapies for the treatment of diseases. Synthetic immunostimulants and nanomaterial immunostimulant systems are indispensable for the activation of the immune system in cancer immunotherapy. Herein,
Autor:
Pu-Guang Chen, Yong-Xiang Chen, Zhi-Hua Huang, Qian-Qian Li, Zhan-Yi Sun, Yan-Mei Li, Yufen Zhao
Publikováno v:
Synlett. 28:1961-1965
Glycopeptide dendrimers are attractive candidates for biomedical applications. Here, an efficient method for preparing multivalent MUC1 glycopeptide dendrimers based on β-cyclodextrin is described. By using copper(I) bromide and thioanisole as a cat
Autor:
Yufen Zhao, Yong-Xiang Chen, Lei Shi, Zhi-Hua Huang, Yue Gao, Yan-Fang Liu, Zhan-Yi Sun, Pu-Guang Chen, Yan-Mei Li
Publikováno v:
Pure and Applied Chemistry. 89:931-939
Cancer immunotherapy based on tumor vaccine is very promising and intriguing for carcinoma treatment. Herein, antitumor nanovaccines consisting of self-assembled chitosan (CS) nanoparticles and two-component mucin1 (MUC1) glycopeptide antigens were r
Autor:
Yuan Cao, Zhi-Wen Hu, Liang-Xiao Chen, Pu-Guang Chen, Yufen Zhao, Yan-Mei Li, Yong-Xiang Chen, Qian-Qian Li
Publikováno v:
Chemical Science
Developing an enzyme-induced gain of function strategy to selectively kill cancer cells with high ALP activity.
The selective killing of cancer cells and the avoidance of drug resistance are still difficult challenges in cancer therapy. Here, we
The selective killing of cancer cells and the avoidance of drug resistance are still difficult challenges in cancer therapy. Here, we