Zobrazeno 1 - 10
of 830
pro vyhledávání: '"Pu Han"'
Autor:
Runchu Zhao, Lili Wu, Junqing Sun, Dezhi Liu, Pu Han, Yue Gao, Yi Zhang, Yanli Xu, Xiao Qu, Han Wang, Yan Chai, Zhihai Chen, George F. Gao, Qihui Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia vaccinees born before the end o
Externí odkaz:
https://doaj.org/article/9664eac7a5d0478bba42dce3729e9ac5
Autor:
Bo Liu, Honghui Liu, Pu Han, Xiaoyun Wang, Chunmei Wang, Xinxin Yan, Wenwen Lei, Ke Xu, Jianjie Zhou, Jianxun Qi, Ruiwen Fan, Guizhen Wu, Wen-xia Tian, George F. Gao, Qihui Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such as
Externí odkaz:
https://doaj.org/article/58723ee042ad435f85dba65f7ee234a2
Publikováno v:
Energy Reports, Vol 9, Iss , Pp 1671-1680 (2023)
SF6 is widely developed and applied in gas insulated electrical equipment due to its excellent arc extinguishing performance and insulation performance. However, SF6 is very destructive to the ozone layer and has a strong cumulative effect on the gre
Externí odkaz:
https://doaj.org/article/91fa1ba6bf754e96974a17756611f973
Autor:
Xiaojie Hu, Wenbin Li, Kang Zeng, Zhongyuan Xu, Changxing Li, Zhuang Kang, Shenglan Li, Xin Huang, Pu Han, Hongmei Lin, Ai-Min Hui, Yan Tan, Lei Diao, Ben Li, Xingli Wang, Zhuli Wu, Xiaoxi Lin
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Surgery is a common treatment strategy for patients with neurofibromatosis type 1 (NF1)-related plexiform neurofibroma (PN) and has limited efficacy. FCN-159 is a novel anti-tumorigenic drug via selective inhibition of MEK1/2. Thi
Externí odkaz:
https://doaj.org/article/40e19bb09d2a4f40ac6a436eed7cad1e
Autor:
Yulei Li, Peipei Liu, Tianjiao Hao, Sheng Liu, Xi Wang, Yufeng Xie, Ke Xu, Wenwen Lei, Cheng Zhang, Pu Han, Ying Li, Xiyue Jin, Yu Huan, Yafei Lu, Rong Zhang, Xiaoyan Li, Xin Zhao, Kun Xu, Pu Liao, Xuancheng Lu, Yuhai Bi, Hao Song, Guizhen Wu, Baoli Zhu, George F. Gao
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Highly contagious respiratory illnesses like influenza and COVID-19 pose serious risks to public health. A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. Here, we generated a chimeric receptor binding domain of t
Externí odkaz:
https://doaj.org/article/78b599e9f4e1408ba9f1981250f3f088
Autor:
Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu, Zepeng Xu, Zhengrong Gao, Xuemei Zhou, Yaling An, Yuxuan Han, Kefang Liu, Xin Zhao, Lianpan Dai, Peiyi Wang, Guizhen Wu, Jianxun Qi, Kun Xu, George F Gao
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011659 (2023)
SARS-CoV-2 variants with severe immune evasion are a major challenge for COVID-19 prevention, especially the circulating Omicron XBB/BQ.1.1/BF.7 strains. Thus, the next-generation of broad-spectrum vaccines are urgently needed. Previously, we develop
Externí odkaz:
https://doaj.org/article/dee577a6f1524b6fa72c01b3e0d331b1
Autor:
Zhennan Zhao, Jingya Zhou, Mingxiong Tian, Min Huang, Sheng Liu, Yufeng Xie, Pu Han, Chongzhi Bai, Pengcheng Han, Anqi Zheng, Lutang Fu, Yuanzhu Gao, Qi Peng, Ying Li, Yan Chai, Zengyuan Zhang, Xin Zhao, Hao Song, Jianxun Qi, Qihui Wang, Peiyi Wang, George F. Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F subst
Externí odkaz:
https://doaj.org/article/90e8f270726e4bf38984d7f2e5f9e902
Autor:
Linjie Li, Pu Han, Baihan Huang, Yufeng Xie, Weiwei Li, Di Zhang, Pengcheng Han, Zepeng Xu, Bin Bai, Jingya Zhou, Xinrui Kang, Xiaomei Li, Anqi Zheng, Rong Zhang, Shitong Qiao, Xin Zhao, Jianxun Qi, Qihui Wang, Kefang Liu, George Fu Gao
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract The Omicron variant of SARS-CoV-2 carries multiple unusual mutations, particularly in the receptor-binding domain (RBD) of the spike (S) protein. Moreover, host-adapting mutations, such as residues 493, 498, and 501, were also observed in th
Externí odkaz:
https://doaj.org/article/edca1a8f88b1468b9628df57774793d6
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Adverse drug reactions (ADR) are directly related to public health and become the focus of public and media attention. At present, a large number of ADR events have been reported on the Internet, but the mining and utilization of such i
Externí odkaz:
https://doaj.org/article/b7d0ffcf251b4090ad3b8fe659444244
Autor:
Zepeng Xu, Xinrui Kang, Pu Han, Pei Du, Linjie Li, Anqi Zheng, Chuxia Deng, Jianxun Qi, Xin Zhao, Qihui Wang, Kefang Liu, George Fu Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
This study documents equine ACE2 (eqACE2) binding to the RBDs of SARS-CoV-2 and related CoVs, revealing a mechanism of eqACE2 binding with RaTG13-RBD, SARS-CoV-2 prototype-RBD and Omicron BA.1-RBD.
Externí odkaz:
https://doaj.org/article/b2d7bd70a2634ce28943fb8ccea2bf04