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Akademický článek

A Precision Engineered Interleukin-2 for Bolstering CD8+ T- and NK-cell Activity without Eosinophilia and Vascular Leak Syndrome in Nonhuman Primates.

Autor: Ma L; Synthorx, Inc., A Sanofi Company, La Jolla, California., Acuff NV; Synthorx, Inc., A Sanofi Company, La Jolla, California., Joseph IB; Synthorx, Inc., A Sanofi Company, La Jolla, California., Ptacin JL; Synthorx, Inc., A Sanofi Company, La Jolla, California., Caffaro CE; Synthorx, Inc., A Sanofi Company, La Jolla, California., San Jose KM; Synthorx, Inc., A Sanofi Company, La Jolla, California., Aerni HR; Synthorx, Inc., A Sanofi Company, La Jolla, California., Carrio R; Sanofi, Orlando, Florida., Byers AM; Sanofi, Orlando, Florida., Herman RW; Synthorx, Inc., A Sanofi Company, La Jolla, California., Pavlova Y; Synthorx, Inc., A Sanofi Company, La Jolla, California., Pena MJ; Synthorx, Inc., A Sanofi Company, La Jolla, California., Chen DB; Synthorx, Inc., A Sanofi Company, La Jolla, California., Buetz C; Synthorx, Inc., A Sanofi Company, La Jolla, California., Ismaili TK; Synthorx, Inc., A Sanofi Company, La Jolla, California., Pham HV; Synthorx, Inc., A Sanofi Company, La Jolla, California., Cucchetti M; Sanofi, Vitry-sur-Seine, France., Sassoon I; Sanofi, Vitry-sur-Seine, France., Koriazova LK; Synthorx, Inc., A Sanofi Company, La Jolla, California., Leveque JA; Synthorx, Inc., A Sanofi Company, La Jolla, California., Shawver LK; Synthorx, Inc., A Sanofi Company, La Jolla, California., Mooney JM; Synthorx, Inc., A Sanofi Company, La Jolla, California., Milla ME; Synthorx, Inc., A Sanofi Company, La Jolla, California.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2799-2814.

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Akademický článek

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism.

Autor: Ptacin JL; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Ma L; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Caffaro CE; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Acuff NV; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Germar K; Sanofi, 350 Water St., Cambridge, MA, 02141, USA., Severy P; Sanofi, 350 Water St., Cambridge, MA, 02141, USA., Qu Y; Sanofi, 350 Water St., Cambridge, MA, 02141, USA., Vela JL; Sanofi, 350 Water St., Cambridge, MA, 02141, USA., Cai X; Sanofi, 350 Water St., Cambridge, MA, 02141, USA., San Jose KM; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Aerni HR; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Chen DB; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Esche E; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Ismaili TK; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Herman R; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Pavlova Y; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Pena MJ; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Nguyen J; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Koriazova LK; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Shawver LK; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Joseph IB; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Mooney J; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA., Peakman M; Sanofi, 350 Water St., Cambridge, MA, 02141, USA., Milla ME; Synthorx, a Sanofi Company, 11099 N. Torrey Pines Rd. Suite 190, La Jolla, CA, 92037, USA. marcos@samsaracap.com.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Mar 26; Vol. 4 (1), pp. 58. Date of Electronic Publication: 2024 Mar 26.

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Akademický článek

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.

Autor: Ptacin JL; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. jptacin@gmail.com., Caffaro CE; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Ma L; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., San Jose Gall KM; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Aerni HR; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Acuff NV; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Herman RW; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Pavlova Y; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Pena MJ; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Chen DB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Koriazova LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Shawver LK; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Joseph IB; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA., Milla ME; Synthorx, Inc., a Sanofi Company, La Jolla, CA, USA. marcos@samsaracap.com.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 09; Vol. 12 (1), pp. 4785. Date of Electronic Publication: 2021 Aug 09.

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Akademický článek

A semi-synthetic organism that stores and retrieves increased genetic information.

Autor: Zhang Y; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA., Ptacin JL; Synthorx, Inc., La Jolla, California 92037, USA., Fischer EC; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA., Aerni HR; Synthorx, Inc., La Jolla, California 92037, USA., Caffaro CE; Synthorx, Inc., La Jolla, California 92037, USA., San Jose K; Synthorx, Inc., La Jolla, California 92037, USA., Feldman AW; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA., Turner CR; Synthorx, Inc., La Jolla, California 92037, USA., Romesberg FE; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

Publikováno v: Nature [Nature] 2017 Nov 29; Vol. 551 (7682), pp. 644-647.

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Akademický článek

Bacterial scaffold directs pole-specific centromere segregation.

Autor: Ptacin JL; Department of Developmental Biology and., Gahlmann A; Department of Chemistry, Stanford University, Stanford, CA 94305., Bowman GR; Department of Developmental Biology and., Perez AM; Department of Developmental Biology and., von Diezmann L; Department of Chemistry, Stanford University, Stanford, CA 94305., Eckart MR; Stanford Protein and Nucleic Acid Facility, Stanford University School of Medicine, Stanford, CA 94305; and., Moerner WE; Department of Chemistry, Stanford University, Stanford, CA 94305., Shapiro L; Department of Developmental Biology and shapiro@stanford.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 May 13; Vol. 111 (19), pp. E2046-55. Date of Electronic Publication: 2014 Apr 28.

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Akademický článek

Oligomerization and higher-order assembly contribute to sub-cellular localization of a bacterial scaffold.

Autor: Bowman GR; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Perez AM, Ptacin JL, Ighodaro E, Folta-Stogniew E, Comolli LR, Shapiro L

Publikováno v: Molecular microbiology [Mol Microbiol] 2013 Nov; Vol. 90 (4), pp. 776-95. Date of Electronic Publication: 2013 Oct 07.

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Akademický článek

Quantitative multicolor subdiffraction imaging of bacterial protein ultrastructures in three dimensions.

Autor: Gahlmann A; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Ptacin JL, Grover G, Quirin S, von Diezmann L, Lee MK, Backlund MP, Shapiro L, Piestun R, Moerner WE

Publikováno v: Nano letters [Nano Lett] 2013 Mar 13; Vol. 13 (3), pp. 987-93. Date of Electronic Publication: 2013 Feb 25.

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