Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Psymberin"'
Autor:
Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/3ce819b3570744e6b93e60cc70e9e3ea
Autor:
Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Colorectal cancer (CRC) is the third most prevalent form of cancer in the United States and results in over 50,000 deaths per year. Treatments for metastatic CRC are limited, and therefore there is an unmet clinical need for more effective therapies.
Externí odkaz:
https://doaj.org/article/a7ae9050338a4bf4b109f13416c91426
Akademický článek
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Publikováno v:
Organic Letters. 21:3670-3673
A convergent, stereocontrolled total synthesis of psymberin, an architecturally complex marine antitumor agent, has been achieved in 27 steps from the known aldehyde 8. Highlights of this synthesis include a novel and efficient transannular Michael a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d2378bf3714c244dbb62de4e2ba62
https://doi.org/10.1021/acs.orglett.9b01113
https://doi.org/10.1021/acs.orglett.9b01113
Autor:
Shun Ichiro Uesugi, Takamichi Imaizumi, Tsubasa Watanabe, Masatoshi Shibuya, Yu Ota, Yoko Nagumo, Takumi Chinen, Takeo Usui, Keisuke Yoshida, Haruna Ebisu, Yoshiharu Iwabuchi, Naoki Kanoh
Publikováno v:
The Journal of Organic Chemistry. 80:12333-12350
Irciniastatin A (a.k.a. psymberin) and irciniastatin B are members of the pederin natural product family, which have potent antitumor activity and structural complexity. Herein, we describe a full account of our total synthesis of (+)-irciniastatin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fb1d269437a6cf50ca6e48e9e6c487
https://doi.org/10.1021/acs.joc.5b02256
https://doi.org/10.1021/acs.joc.5b02256
Autor:
Agustinus Robert Uria
Publikováno v:
Squalen, Vol 10, Iss 1, Pp 35-49 (2015)
Symbiotic bacteria associated with marine sponges have frequently been proposed as the true producer of many bioactive natural products with potent anticancer activities. However, the majority of these complex symbiotic bacteria cannot be cultivated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5c36da6d6da1154467831ac5380bf9
http://bbp4b.litbang.kkp.go.id/squalen-bulletin/index.php/squalen/article/view/131
http://bbp4b.litbang.kkp.go.id/squalen-bulletin/index.php/squalen/article/view/131
Publikováno v:
Handbook of Anticancer Drugs from Marine Origin
Pederin, psymberin, and mycalamides are related members of a relatively new family of potent natural antiviral and antitumor compounds originally isolated from marine sponges in 1988. This natural family of chemicals is of great interest to medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::57d978dfc0b66aeb10f8463306fdb8fd
http://europepmc.org/articles/PMC7123710
http://europepmc.org/articles/PMC7123710
Publikováno v:
Organic Letters. 14:4350-4353
The total synthesis and structural confirmation of the marine sponge cytotoxin (-)-irciniastatin B has been achieved via a unified strategy employing a late-stage, selective deprotection/oxidation sequence that provides access to both (+)-irciniastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd272fe3539778f2346362e295ae6ad
https://doi.org/10.1021/ol301783p
https://doi.org/10.1021/ol301783p
Autor:
Max Bielitza, Jörg Pietruszka
Publikováno v:
Synlett. 23:1625-1628
We report an alternative synthetic route towards the tetrahydropyran core of psymberin. The key steps are a catalytic enantioselective Mukaiyama aldol reaction and a syn reduction, which allowed for the rapid assembly of a γ-lactone as a precursor f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d68ecc5215599545e988af0a904e7e82
https://doi.org/10.1055/s-0031-1290379
https://doi.org/10.1055/s-0031-1290379
Autor:
Jason C. Rech, Billy W. Day, Paul E. Floreancig, Michael E. Green, Shuangyi Wan, Fanghui Wu, Raghavan Balachandran, W. Seth Horne
Publikováno v:
Journal of the American Chemical Society. 133:16668-16679
The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff483100cb300ed223e3a111ce7d2096
https://doi.org/10.1021/ja207331m
https://doi.org/10.1021/ja207331m