Psymberin, a marine-derived natural product, induces cancer cell growth arrest and protein translation inhibition

Autor: Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

Colorectal cancer (CRC) is the third most prevalent form of cancer in the United States and results in over 50,000 deaths per year. Treatments for metastatic CRC are limited, and therefore there is an unmet clinical need for more effective therapies.

Externí odkaz: https://doaj.org/article/a7ae9050338a4bf4b109f13416c91426

Corrigendum: Psymberin, a marine-derived natural product, induces cancer cell growth arrest and protein translation inhibition.

Autor: Dayanidhi DL; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States.; Center for Genomics and Computational Biology, Duke University, Durham, NC, United States., Somarelli JA; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States., Mantyh JB; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States.; Center for Genomics and Computational Biology, Duke University, Durham, NC, United States., Rupprecht G; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States.; Center for Genomics and Computational Biology, Duke University, Durham, NC, United States., Roghani RS; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States.; Center for Genomics and Computational Biology, Duke University, Durham, NC, United States., Vincoff S; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States., Shin I; Department of Chemistry, Duke University, Durham, NC, United States., Zhao Y; Department of Chemistry, Duke University, Durham, NC, United States., Kim SY; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, United States., McCall S; Department of Pathology, Duke University, Durham, NC, United States., Hong J; Department of Chemistry, Duke University, Durham, NC, United States.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States., Hsu DS; Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, United States.; Center for Genomics and Computational Biology, Duke University, Durham, NC, United States.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2023 May 31; Vol. 10, pp. 1193745. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).

Total Synthesis of Psymberin (Irciniastatin A)

Autor: Jie Yu, Yian Guo, Mingze Yang, Tao Ye

Publikováno v: Organic Letters. 21:3670-3673

A convergent, stereocontrolled total synthesis of psymberin, an architecturally complex marine antitumor agent, has been achieved in 27 steps from the known aldehyde 8. Highlights of this synthesis include a novel and efficient transannular Michael a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d2378bf3714c244dbb62de4e2ba62
https://doi.org/10.1021/acs.orglett.9b01113

Synthesis of 8-Desmethoxy Psymberin: A Putative Biosynthetic Intermediate Towards the Marine Polyketide Psymberin.

Autor: Bielitza, Max¹, Pietruszka, Jörg¹ j.pietruszka@fz‐juelich.de

Publikováno v: Chemistry - A European Journal. Jun2013, Vol. 19 Issue 25, p8300-8308. 9p.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.