Novel Toscana Virus Reverse Genetics System Establishes NSs as an Antagonist of Type I Interferon Responses

Autor: Franziska Woelfl, Psylvia Léger, Nadia Oreshkova, Felix Pahmeier, Stefan Windhaber, Jana Koch, Megan Stanifer, Gleyder Roman Sosa, Zina M. Uckeley, Felix A. Rey, Steeve Boulant, Jeroen Kortekaas, Paul J. Wichgers Schreur, Pierre-Yves Lozach

Publikováno v: Viruses, Vol 12, Iss 4, p 400 (2020)

The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we have developed a T7 RNA polymerase-driven reverse genetics system to recover infectious part

Externí odkaz: https://doaj.org/article/e379221c062747039e896e986ba66082

NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice

Autor: Susann Kummer, Hans-Georg Kräusslich, Psylvia Léger, Steeve Boulant, Jana Koch, Pierre-Yves Lozach, Megan L. Stanifer, Qilin Xin, Michèle Bouloy, Robin Burk, Carmen Nussbaum-Krammer, Carole Tamietti, Marie Flamand, Karsten Richter, Eliana Nachman, Xavier Montagutelli

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.3281. ⟨10.1038/s41467-020-17101-y⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3281. ⟨10.1038/s41467-020-17101-y⟩

Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to specific human illnesses such as Alzheimer’s disease. Here we show that the major virulence factor of Rift Valley fever virus, the protein NSs, forms fil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcefe0a320669003cafef628cf559b3d
https://doaj.org/article/74f1f51789f34696aeebabd489877a8c

Novel toscana virus reverse genetics system establishes NSS as an antagonist of type I interferon responses

Autor: Megan L. Stanifer, Paul J. Wichgers Schreur, Felix Pahmeier, Pierre-Yves Lozach, Zina M. Uckeley, Stefan Windhaber, Gleyder Roman Sosa, Psylvia Léger, Steeve Boulant, Félix A. Rey, Franziska Woelfl, Nadia Oreshkova, Jeroen Kortekaas, Jana Koch

Publikováno v: Viruses
Volume 12
Issue 4
Viruses, 12(4)
Viruses, MDPI, 2020, 12 (4), pp.400. ⟨10.3390/v12040400⟩
Viruses, vol 12, iss 4
Viruses, Vol 12, Iss 400, p 400 (2020)
Viruses 12 (2020) 4

The sand fly-borne Toscana virus (TOSV) is the major cause of human meningoencephalitis in the Mediterranean basin during the summer season. In this work, we have developed a T7 RNA polymerase-driven reverse genetics system to recover infectious part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033a953fc500d7992667a7cbaa54e3fb
https://doi.org/10.3390/v12040400

Differential Use of the C-Type Lectins L-SIGN and DC-SIGN for Phlebovirus Endocytosis

Autor: Ronan N. Rouxel, Pierre-Yves Lozach, Marilou Tétard, Marie Flamand, Psylvia Léger, Berthe Youness, Nicole Cordes

Publikováno v: Traffic. 17:639-656

Bunyaviruses represent a growing threat to humans and livestock globally. The receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely unidentified and poorly characterized. DC-SIGN is a C-typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d319e2a419b0147cfbe68ad14aad1b19
https://doi.org/10.1111/tra.12393

Deciphering Virus Entry with Fluorescently Labeled Viral Particles

Autor: Psylvia Léger, Anja B. Hoffmann, Magalie Mazelier, Pierre-Yves Lozach

Publikováno v: Influenza Virus
Influenza Virus, pp.159-183, 2018, ⟨10.1007/978-1-4939-8678-1_8⟩
Methods in Molecular Biology ISBN: 9781493986774

To infect host cells, viruses have to gain access to the intracellular compartment. The infection process starts with the attachment of viruses to the cell surface. Then a complex series of events, highly dynamic, tightly intricate, and often hard to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406202413f3d4cf3042941238df29706
https://hal.inrae.fr/hal-03331553