Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia

Autor: Lin, Bochao D., Pinzón-Espinosa, Justo, Blouzard, Elodie, Van Der Horst, Marte Z., Okhuijsen-pfeifer, Cynthia, Van Eijk, Kristel R., Guloksuz, Sinan, Peyrot, Wouter J., Luykx, Jurjen J., Hasan, Alkomiet, Wagner, Elias, Pantelis, Christos, Everall, Ian P., Ayhan, Y., Babaoğlu, M. O., Bak, Maarten, Alink, Wouter, Beld, E, Bouhuis, A, Edlinger, M, Erdoğan, I .m., Gutwinski, Stefan, Hallikainen, Tero, Jeger-land, E, Lähteenvuo, Markku, De Koning, Mariken B., Morgenroth, Carla, Müderrisoğlu, A., Oviedo-salcedo, Tatiana, Schreiter, Stefanie, Repo-tiihonen, Eila, Tuppurainen, Heli, Veereschild, Mike, Veerman, Selene R.t., Cohen, Dan, De Vos, M, Bogers, Jan P.a.m., Anıl Yağcıoğlu, A.e., Tiihonen, Jari, Ripke, Stephan, Bousman, Chad A., Van Beek, H, Van Der Horst, Marte, Van Eijk, Kristel, Ertuğrul, A., Yoca, G., Görlitz, T., Grootens, K., Leucht, Stefan, Narang, A., Schneider-thoma, J., Kahn, René S., Bekema, Erwin, Kleymann, Phillip, Alizadeh, Behrooz Z., Van Amelsvoort, Therese, Cahn, Wiepke, De Haan, Lieuwe, Schirmbeck, Frederike, Simons, Claudia J.p., Van Os, Jim, Rutten, Bart, Van Winkel, Ruud

Publikováno v: JAMA Psychiatry. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA Psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234
JAMA psychiatry, 80(2), 181-185. American Medical Association
JAMA Psychiatry, 80(2), 181-185. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234

ImportancePredictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b30808f0062dc9476f2ac63918f219
http://www.scopus.com/inward/record.url?scp=85147317982&partnerID=8YFLogxK

Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients

Autor: Sarah Steeg, Darren M. Ashcroft, Matthew J. Carr, Navneet Kapur, Trudie Chalder, Kathryn M Abel, Sally McManus, Carolyn Chew-Graham, Matthias Pierce, Roger T. Webb, Holly Hope

Publikováno v: JAMA Network Open
Abel, K M, Carr, M J, Ashcroft, D M, Chalder, T, Chew-Graham, C A, Hope, H, Kapur, N, McManus, S, Steeg, S, Webb, R T & Pierce, M 2021, ' Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients ', JAMA Network Open, vol. 4, no. 11, e2134803 . https://doi.org/10.1001/jamanetworkopen.2021.34803

Key Points Question Is SARS-CoV-2 infection associated with risk of subsequent psychiatric morbidity, sleep problems, or fatigue? Findings In this cohort study of the health care records of 11 923 105 patients, including 226 521 patients with SARS-Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d4d561f8cc0cd52cb083ba59bba040
https://doi.org/10.1001/jamanetworkopen.2021.34803

Discontinuation of antipsychotic medication-time to rethink trial design

Autor: Nikolai Albert, Iris E. C. Sommer, Wim Veling, Marieke J. H. Begemann, Eoin Killackey, Merete Nordentoft, Amber Weller, Kelly Allott, Helene Speyer

Publikováno v: The Lancet. Psychiatry, 7(10), 841-842. ELSEVIER SCI LTD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba348eab22c1ac7ef7b6a9f6d92554c
https://doi.org/10.1016/S2215-0366(20)30340-0

N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis

Autor: Matcheri S. Keshavan, Martine Cleusix, Raoul Jenni, Michel Cuenod, Philippe Conus, Kim Q. Do, Lijing Xin, Luis Alameda, Chin B. Eap, Rolf Gruetter, T-U Wilson Woo, Philippe Golay, Larry J. Seidman, Thierry Buclin, Philipp S. Baumann, Carina Ferrari, Margot Fournier, Joanne Wojcik, Mehdi Gholam-Rezaee, Ann Cousins

Publikováno v: Schizophrenia Bulletin
Schizophrenia bulletin, vol. 44, no. 2, pp. 317-327

Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N-acetylcysteine (NAC) led to negative symptom reductions in chronic patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9385fb8e8aa5e7e808a58317877257a
https://pubmed.ncbi.nlm.nih.gov/29462456

Adverse cardiac events in out-patients initiating clozapine treatment: a nationwide register-based study

Autor: Bjørn H Ebdrup, Kristian Kragholm, Dan Siskind, Christopher Rohde, Christoffer Polcwiartek, Jimmi Nielsen

Publikováno v: Rohde, C, Polcwiartek, C, Kragholm, K, Ebdrup, B H, Siskind, D & Nielsen, J 2018, ' Adverse cardiac events in out-patients initiating clozapine treatment : a nationwide register-based study ', Acta Psychiatrica Scandinavica, vol. 137, no. 1, pp. 47-53 . https://doi.org/10.1111/acps.12827

OBJECTIVE: Using national Danish registers, we estimated rates of clozapine-associated cardiac adverse events. Rates of undiagnosed myocarditis were estimated by exploring causes of death after clozapine initiation.METHOD: Through nationwide health r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82431a37e820cf7991b54506be74f96
https://pubmed.ncbi.nlm.nih.gov/29064084