Tissue-Resident Memory T Cells in Skin Diseases:A Systematic Review

Autor: Josephine Mistegård, Claus Johansen, Lars Iversen, Thomas Emmanuel, Anne Bregnhøj

Publikováno v: Emmanuel, T, Mistegård, J, Bregnhøj, A, Johansen, C & Iversen, L 2021, ' Tissue-Resident Memory T Cells in Skin Diseases : A Systematic Review ', International Journal of Molecular Sciences, vol. 22, no. 16 . https://doi.org/10.3390/ijms22169004
Emmanuel, T, Mistegård, J, Bregnhøj, A, Johansen, C & Iversen, L 2021, ' Tissue-resident memory t cells in skin diseases : A systematic review ', International Journal of Molecular Sciences, vol. 22, no. 16, 9004 . https://doi.org/10.3390/ijms22169004
International Journal of Molecular Sciences, Vol 22, Iss 9004, p 9004 (2021)
International Journal of Molecular Sciences

In health, the non-recirculating nature and long-term persistence of tissue-resident memory T cells (TRMs) in tissues protects against invading pathogens. In disease, pathogenic TRMs contribute to the recurring traits of many skin diseases. We aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c03022c2b85aa284021f6cea28c526
https://pure.au.dk/portal/da/publications/tissueresident-memory-t-cells-in-skin-diseases(c373c8f6-96ef-4ca6-81ac-d18f7b623ec8).html

TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

Autor: Alexander A. Navarini, Curdin Conrad, Alessio Mylonas, Anne-Karine Lapointe, Jeremy Di Domizio, Olivier Demaria, Michel Gilliet, Cyrine Belkhodja, Lars E. French, Maxime Vernez

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 25

Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis. The pathogenesis of this side effect and its distinction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbc7decb248c10970a313c075620f0f
https://doaj.org/article/180fc992d72e4fcbbf1d606055e86015

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

Autor: Lukas Flatz, Pascale Zwicky, Alexander A. Navarini, Phil F. Cheng, Burkhard Becher, Reinhard Dummer, Tom Hartwig, Nikhil Yawalkar, Curdin Conrad, Bettina Schreiner, Christoph Schlapbach

Publikováno v: Cell Reports, Vol 25, Iss 13, Pp 3564-3572.e4 (2018)
Cell reports, vol. 25, no. 13, pp. 3564-3572.e4
Hartwig, Tom; Zwicky, Pascale; Schreiner, Bettina; Yawalkar, Nikhil; Cheng, Phil; Navarini, Alexander; Dummer, Reinhard; Flatz, Lukas; Conrad, Curdin; Schlapbach, Christoph; Becher, Burkhard (2018). Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation. Cell reports, 25(13), 3564-3572.e4. Cell Press 10.1016/j.celrep.2018.12.012

Summary: Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease mediated by the interplay of T cells and polymorphonuclear granulocytes. Although preclinical studies have provided insights into the mechanisms of dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f131119d7f83da2ba133932aa15121a7
https://doi.org/10.1016/j.celrep.2018.12.012

Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation

Autor: Stephanie Zwicker, D. Bureik, Aleksandra Batycka-Baran, Thomas Ruzicka, Simon Rothenfusser, Andreas Schmidt, Ronald Wolf, Michel Gilliet, Eva Hattinger, Peter-Arne Gerber

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175153 (2017)
PloS one, vol. 12, no. 4, pp. e0175153
PLoS ONE

IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. Its production is controlled at the transcriptional level and by subsequent posttranslational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0206ce2320093f408cfb6eb3ea3f67da
https://doi.org/10.1371/journal.pone.0175153

Altered distribution of heparan sulfate proteoglycans in psoriasis

Publikováno v: Acta dermato-venereologica. 77(2):105-109

Heparan sulfate proteoglycans (HSPGs) are components of the basement membrane (BM) of various tissues. They consist of a core protein and negatively charged glycosaminoglycan side chains: the heparan sulfate (HS) moieties. In psoriasis, uninvolved sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::b0a87c728a0558c63bacc2bf74396637
https://hdl.handle.net/11370/453b6aea-64eb-4489-bd64-657f5b24b5bf