Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae

Autor: Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard Baker, Munira A. Basrai

Publikováno v: G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2057-2068 (2020)

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN

Externí odkaz: https://doaj.org/article/18406182fbf848b19238234c13a0f3b1

N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin

Autor: Richard Baker, Yoshimitsu Takahashi, Kentaro Ohkuni, Jack Warren, Reuben Levy-Myers, Wei-Chun Au, Munira A. Basrai

Publikováno v: G3: Genes|Genomes|Genetics

Stringent regulation of cellular levels of evolutionarily conserved centromeric histone H3 variant (CENP-A in humans, CID in flies, Cse4 in yeast) prevents its mislocalization to non-centromeric chromatin. Overexpression and mislocalization of CENP-A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4560b4c0839782648217118a2c76c41f
https://doi.org/10.1534/g3.117.300419

N-terminal formylmethionine as a novel initiator and N-degron of eukaryotic proteins

Autor: Jeong-Mok Kim

Publikováno v: BMB Reports

The ribosomal synthesis of proteins in the eukaryotic cytosol has always been thought to start from the unformylated N-terminal (Nt) methionine (Met). In contrast, in virtually all nascent proteins in bacteria and eukaryotic organelles, such as mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662d026f6f99846b12d8a059e067058a
https://pubmed.ncbi.nlm.nih.gov/30885288

Ubiquitin protease Ubp8 is necessary for S. cerevisiae respiration

Autor: Arianna Montanari, Patrizia Filetici, Mariafrancesca La Greca, Raffaele Antonio Palladino, Serena Di Vito, Silvia Francisci, Manuela Leo, Barbara Traversetti, Giulia Fanelli

Publikováno v: Biochimica et biophysica acta. Molecular cell research 1865 (2018): 1491–1500. doi:10.1016/j.bbamcr.2018.07.025
info:cnr-pdr/source/autori:Leo M.; Fanelli G.; Di Vito S.; Traversetti B.; La Greca M.; Palladino R.A.; Montanari A.; Francisci S.; Filetici P./titolo:Ubiquitin protease Ubp8 is necessary for S. cerevisiae respiration/doi:10.1016%2Fj.bbamcr.2018.07.025/rivista:Biochimica et biophysica acta. Molecular cell research/anno:2018/pagina_da:1491/pagina_a:1500/intervallo_pagine:1491–1500/volume:1865

Healthy mitochondria are required in cell metabolism and deregulation of underlying mechanisms is often involved in human diseases and neurological disorders. Post-translational modifications of mitochondrial proteins regulate their function and acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0bf0035de5bf488c2f4009aadd972a
https://pubmed.ncbi.nlm.nih.gov/30077637

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