Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports $Pseudomonas\ aeruginosa$-driven pathology

Autor: Flavie Moreau, Geanncarlo Lugo-Villarino, Aurélien Boyance, Arnaud Métais, Peter J. Peters, Karin Santoni, Céline Cougoule, Stephen Adonai Leon-Icaza, Hans Clevers, Lise Lefèvre, Etienne Meunier, Yoann Rombouts, Agnès Coste, Pierre-Jean Bordignon, Miriam Pinilla, Emmanuelle Naser, Audrey Hessel, David Péricat, Ina Attrée, Rémi Planès, Nino Iakobachvili, Dara W. Frank, Elif Eren, Salimata Bagayoko, Céline Berrone

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2021, 17 (9), pp.e1009927. ⟨10.1371/journal.ppat.1009927⟩
PLOS Pathogens
PLoS Pathogens, 17(9). Public Library of Science
PLoS Pathogens, Vol 17, Iss 9, p e1009927 (2021)
PLoS Pathogens, Public Library of Science, 2021, 17 (9), pp.e1009927. ⟨10.1371/journal.ppat.1009927⟩
PLOS PATHOGENS, 17(9):e1009927. Public Library of Science

Regulated cell necrosis supports immune and anti-infectious strategies of the body; however, dysregulation of these processes drives pathological organ damage. Pseudomonas aeruginosa expresses a phospholipase, ExoU that triggers pathological host cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e894e6c2b90a46e338f26354fa5a061
https://hal.science/hal-03355818/document

Binding interface between the Salmonella σ(S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl

Autor: Christina Sizun, Jacques Bellalou, Claudine Mayer, Véronique Monteil, Mireille Nowakowski, Fabienne Levi-Acobas, Françoise Norel, François Bontems, Paola Cavaliere

Publikováno v: Scientific Reports
Scientific Reports, 2015, 5, pp.13564. ⟨10.1038/srep13564⟩
Scientific Reports, Nature Publishing Group, 2015, 5, pp.13564. ⟨10.1038/srep13564⟩
Scientific Reports, Nature Publishing Group, 2015, 5, pp.13564. 〈10.1038/srep13564〉
HAL-Pasteur
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International audience; In many Gram-negative bacteria, including Salmonella enterica serovar Typhimurium (S. Typhimurium), the sigma factor RpoS/σ S accumulates during stationary phase of growth, and associates with the core RNA polymerase enzyme (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7957a2006130b55f47305b95d654bd3c
https://hal-pasteur.archives-ouvertes.fr/pasteur-01392714/file/srep13564.pdf

Systematic mutational analysis of the putative hydrolase PqsE: toward a deeper molecular understanding of virulence acquisition in Pseudomonas aeruginosa

Autor: Eric Déziel, Benjamin Folch, Nicolas Doucet

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73727 (2013)
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (9), pp.e73727. ⟨10.1371/journal.pone.0073727⟩

International audience; Pseudomonas aeruginosa is an important opportunistic human pathogen that can establish bacterial communication by synchronizing the behavior of individual cells in a molecular phenomenon known as "quorum sensing". Through an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1114afd1d349bf84990a3433ef5f1b52
http://europepmc.org/articles/PMC3769375?pdf=render

Unexpected interaction of a siderophore with aluminum and its receptor

Autor: Pierre Cornelis

Pseudomonas aeruginosa is an important opportunistic pathogen, and one of the major factors contributing to its virulence is the capacity to produce a high-affinity iron-scavenging siderophore, pyoverdine ([10][1], [11][2], [21][3]). Pyoverdines form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa8808b0bd9031e6027258900eb5937
https://hdl.handle.net/20.500.14017/9950ee07-f5aa-47a4-8990-82565b36c3d9

The structure-activity relationship of ferric pyoverdine bound to its outer membrane transporter: implications for the mechanism of iron uptake

Autor: Bruno Kieffer, L. Rochet, Gaëtan L.A. Mislin, V. Schons, R. A. Atkinson, Isabelle J. Schalk, Christophe Hennard, R. Graff, Mohamed A. Abdallah, C. Dugave

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2005, 44 (43), pp.14069-79. ⟨10.1021/bi051155s⟩
Biochemistry, American Chemical Society, 2005, 44, pp.14069-79
Biochemistry, 2005, 44 (43), pp.14069-79. ⟨10.1021/bi051155s⟩

0006-2960 (Print) Journal Article; Under iron limitation, Pseudomonas aeruginosa ATCC 15692 secretes a major siderophore, pyoverdine I (PvdI). This molecule chelates iron in the extracellular medium and shuttles it into the cells via a specific outer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e836de6abf83e7234dc8b3dce3be66
https://pubmed.ncbi.nlm.nih.gov/16245923