Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity

Autor: Bögi K, Ps, Lorenzo, Szállási Z, Acs P, Gs, Wagner, Pm, Blumberg

Publikováno v: Europe PubMed Central

Protein kinase C (PKC) represents the major, high-affinity receptor for the phorbol esters as well as for a series of structurally diverse natural products. The phorbol esters function by binding to the tandem C1a and C1b domains in PKC, leading to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ceb575b9093257ab2194c2064407b3c4
https://pubmed.ncbi.nlm.nih.gov/9537243

RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.

Autor: Sharma A; Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA., Luke CT, Dower NA, Stone JC, Lorenzo PS

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2010 May 21; Vol. 285 (21), pp. 15724-30. Date of Electronic Publication: 2010 Mar 22.

A 2-substituted prodiginine, 2-(p-hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra.

Autor: Fehér D; Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 96822, USA., Barlow RS, Lorenzo PS, Hemscheidt TK

Publikováno v: Journal of natural products [J Nat Prod] 2008 Nov; Vol. 71 (11), pp. 1970-2. Date of Electronic Publication: 2008 Oct 15.

Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin.

Autor: Oki-Idouchi CE; Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA., Lorenzo PS

Publikováno v: Cancer research [Cancer Res] 2007 Jan 01; Vol. 67 (1), pp. 276-80.

Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.

Autor: Tuthill MC; Natural Products and Cancer Biology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Room 315, 1236 Lauhala Street, Honolulu, HI 96813, USA., Oki CE, Lorenzo PS

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2006 Mar; Vol. 5 (3), pp. 602-10.