Two desmin gene mutations associated with myofibrillar myopathies in Polish families.

Autor: Jakub Piotr Fichna, Justyna Karolczak, Anna Potulska-Chromik, Przemyslaw Miszta, Mariusz Berdynski, Agata Sikorska, Slawomir Filipek, Maria Jolanta Redowicz, Anna Kaminska, Cezary Zekanowski

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115470 (2014)

Desmin is a muscle-specific intermediate filament protein which forms a network connecting the sarcomere, T tubules, sarcolemma, nuclear membrane, mitochondria and other organelles. Mutations in the gene coding for desmin (DES) cause skeletal myopath

Externí odkaz: https://doaj.org/article/577b5d04d82646d3880d1430b946217f

Cryo-EM structure of the native rhodopsin dimer in nanodiscs

Autor: Oliver P. Ernst, Przemyslaw Miszta, Dorothy Yanling Zhao, Julia Mahamid, Takefumi Morizumi, Matthias Pöge, Slawomir Filipek, Sahil Gulati, Wolfgang Baumeister, Jianye Zhang, Ned Van Eps, Jürgen M. Plitzko, Krzysztof Palczewski

Publikováno v: J Biol Chem
The Journal of biological chemistry, vol 294, iss 39

Imaging of rod photoreceptor outer-segment disc membranes by atomic force microscopy and cryo-electron tomography has revealed that the visual pigment rhodopsin, a prototypical class A G protein-coupled receptor (GPCR), can organize as rows of dimers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf54c4ea13a66b24452d68d6c27175
https://doi.org/10.1074/jbc.ra119.010089

Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

Autor: Przemyslaw Miszta, Piotr Krzeczyński, Slawomir Filipek, Przemysław Rzodkiewicz, Olga Michalak, Pakhuri Mehta

Publikováno v: Life
Life, Vol 10, Iss 50, p 50 (2020)

The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an increasingly attractive drug target. It plays an indispensable role in many cellular pathways, and numerous H4R ligands are being studied for the treatment of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff95851b19ddd9df192f02776ab4d95c
http://europepmc.org/articles/PMC7235846

GPCRmd uncovers the dynamics of the 3D-GPCRome

Autor: Minos-Timotheos Matsoukas, David E. Gloriam, Ismael Rodríguez-Espigares, Agnieszka Sztyler, Davide Provasi, Arnau Cordomí, Peter Kolb, David Aranda-García, Toni Giorgino, Ferran Sanz, Mariona Torrens-Fontanals, Peter W. Hildebrand, Maria Marti-Solano, Mireia Olivella, Alejandro Varela-Rial, Gianni De Fabritiis, José Carlos Gómez-Tamayo, Laura Pérez-Benito, Tomasz Maciej Stepniewski, Eduardo Mayol, Silvana Vasile, Slawomir Filipek, Ulrich Zachariae, Jens Carlsson, Dorota Latek, Harel Weinstein, Gáspár Pándy-Szekeres, Przemyslaw Miszta, Willem Jespers, Nathalie Worp, Mireia Jiménez-Rosés, Juan Manuel Ramírez-Anguita, Marta Filizola, George Khelashvili, Angel Gonzalez, Brian Medel Lacruz, Pierre Matricon, Iván Rodríguez-Torrecillas, Xavier Deupi, Adrián Morales-Pastor, Jessica Sallander, Hugo Gutiérrez-de-Terán, Johanna K. S. Tiemann, Jana Selent, Jon Kapla, Ramon Guixà-González, Santiago Ríos

Publikováno v: Nature Methods
Nature methods (Online) 17 (2020): 777–787. doi:10.1038/s41592-020-0884-y
info:cnr-pdr/source/autori:Rodríguez-Espigares, Ismael; Torrens-Fontanals, Mariona; Tiemann, Johanna K.S.; Aranda-García, David; Ramírez-Anguita, Juan Manuel; Stepniewski, Tomasz Maciej; Worp, Nathalie; Varela-Rial, Alejandro; Morales-Pastor, Adrián; Medel-Lacruz, Brian; Pándy-Szekeres, Gáspár; Mayol, Eduardo; Giorgino, Toni; Carlsson, Jens; Deupi, Xavier; Filipek, Slawomir; Filizola, Marta; Gómez-Tamayo, José Carlos; Gonzalez, Angel; Gutiérrez-de-Terán, Hugo; Jiménez-Rosés, Mireia; Jespers, Willem; Kapla, Jon; Khelashvili, George; Kolb, Peter; Latek, Dorota; Marti-Solano, Maria; Matricon, Pierre; Matsoukas, Minos Timotheos; Miszta, Przemyslaw; Olivella, Mireia; Perez-Benito, Laura; Provasi, Davide; Ríos, Santiago; R. Torrecillas, Iván; Sallander, Jessica; Sztyler, Agnieszka; Vasile, Silvana; Weinstein, Harel; Zachariae, Ulrich; Hildebrand, Peter W.; De Fabritiis, Gianni; Sanz, Ferran; Gloriam, David E.; Cordomi, Arnau; Guixà-González, Ramon; Selent, Jana/titolo:GPCRmd uncovers the dynamics of the 3D-GPCRome/doi:10.1038%2Fs41592-020-0884-y/rivista:Nature methods (Online)/anno:2020/pagina_da:777/pagina_a:787/intervallo_pagine:777–787/volume:17

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes and are the most frequent targets of approved drugs. The explosion in the number of new three-dimensional (3D) molecular structures of GPCRs (3D-GPCRome) over the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb6367e2808eb6eb81235f76f7853ad

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models

Autor: Agnieszka Sztyler, Slawomir Filipek, Przemyslaw Miszta, Jakub Jakowiecki, Dorota Latek, Pawel Pasznik

Publikováno v: Nucleic Acids Research

Due to the involvement of G protein-coupled receptors (GPCRs) in most of the physiological and pathological processes in humans they have been attracting a lot of attention from pharmaceutical industry as well as from scientific community. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec165559c627a8f83c31dc98470387
https://doi.org/10.1093/nar/gky429