Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Przemyslaw Grudnik"'
Autor:
Ismael Rodriguez, Justyna Kocik-Krol, Lukasz Skalniak, Bogdan Musielak, Aneta Wisniewska, Agnieszka Ciesiołkiewicz, Łukasz Berlicki, Jacek Plewka, Przemyslaw Grudnik, Malgorzata Stec, Maciej Siedlar, Tad A. Holak, Katarzyna Magiera-Mularz
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-8 (2023)
Abstract Recent advances in immuno-oncology have opened up new and impressive treatment options for cancer. Notwithstanding, overcoming the limitations of the current FDA-approved therapies with monoclonal antibodies (mAbs) that block the PD-1/PD-L1
Externí odkaz:
https://doaj.org/article/4d89b666a61e477c85c3abb086044bda
Autor:
Krzysztof M. Zak, Mark J. Bostock, Irena Waligorska, Ida B. Thøgersen, Jan J. Enghild, Grzegorz M. Popowicz, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)
Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a “cysteine-switch” mechanism exerted by Cys23 in the
Externí odkaz:
https://doaj.org/article/facc41ee0c7f40019822708c69e05cfb
Autor:
Stanislaw Malicki, Miroslaw Ksiazek, Pawel Majewski, Aleksandra Pecak, Piotr Mydel, Przemyslaw Grudnik, Grzegorz Dubin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 638-643 (2019)
Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we developed a family of novel,
Externí odkaz:
https://doaj.org/article/bdf17d8dea0e4e3a9c78cd0b1d122473
Autor:
Katarzyna Magiera-Mularz, Justyna Kocik, Bogdan Musielak, Jacek Plewka, Dominik Sala, Monika Machula, Przemyslaw Grudnik, Malgorzata Hajduk, Marcin Czepiel, Maciej Siedlar, Tad A. Holak, Lukasz Skalniak
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101960- (2021)
Summary: In the development of PD-L1-blocking therapeutics, it is essential to transfer initial in vitro findings into proper in vivo animal models. Classical immunocompetent mice are attractive due to high accessibility and low experimental costs. H
Externí odkaz:
https://doaj.org/article/60bd188bec4540759a79eec5931735b6
Autor:
Malgorzata Magoch, Przemyslaw Nogly, Przemyslaw Grudnik, Pikyee Ma, Bozena Boczkus, Ana Rute Neves, Margarida Archer, Grzegorz Dubin
Publikováno v:
Molecules, Vol 25, Iss 20, p 4633 (2020)
Streptococcus pneumoniae is a frequent bacterial pathogen of the human respiratory tract causing pneumonia, meningitis and sepsis, a serious healthcare burden in all age groups. S. pneumoniae lacks complete respiratory chain and relies on carbohydrat
Externí odkaz:
https://doaj.org/article/e2e785fbef0144cd87a83d667bce0aa7
Autor:
Keerthiraju Ethiraju Ravichandran, Kaduhr, Lars, Kwasna, Dominika, Glatt, Sebastian, Perez, Sebastian Guzman, Leidel, Sebastian, Brachmann, Cindy, Mikołaj Sokołowski, Rościsław Krutyhołowa, Schaffrath, Raffael, Jankowska, Urszula, Przemyslaw Grudnik, Bozena Skupien-Rabian, Wilk, Piotr, Shvetsova, Ekaterina, Kösters, Manuel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1aad7978397128e6c8014a640ff926
Autor:
Keerthiraju Ethiraju Ravichandran, Glatt, Sebastian, Leidel, Sebastian, Pabis, Marta, Rościsław Krutyhołowa, Mikołaj Sokołowski, Jankowska, Urszula, Przemyslaw Grudnik, Termathe, Martin, Kienast, Sandra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64059055dbc979d08830454a0f9412d2
Autor:
Piotr Wilk, Artur Biela, Jonathan G. Heddle, Julian David Janna Olmos, Przemyslaw Grudnik, Joanna Markiewicz-Mizera, Małgorzata Jemioła-Rzemińska, Mantu Kumar, Soumyananda Chakraborti, Andrzej Górecki
Publikováno v:
Nanoscale. 13(27)
Cage forming proteins have numerous potential applications in biomedicine and biotechnology, where the iron storage ferritin is a widely used example. However, controlling ferritin cage assembly/disassembly remains challenging, typically requiring ex
Autor:
Ida B. Thøgersen, Krzysztof M. Zak, Mark J Bostock, Jan Potempa, Irena Waligorska, Jan J. Enghild, Grzegorz M Popowicz, Przemyslaw Grudnik, Miroslaw Ksiazek
Publikováno v:
Zak, K M, Bostock, M J, Waligorska, I, Thøgersen, I B, Enghild, J J, Popowicz, G M, Grudnik, P, Potempa, J & Ksiazek, M 2021, ' Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia ', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 36, no. 1, pp. 1267-1281 . https://doi.org/10.1080/14756366.2021.1937619
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)
Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a “cysteine-switch” mechanism exerted by Cys23 in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe83f78b12e748673165bea71b66b00
Autor:
Tad A. Holak, Dominik Sala, Katarzyna Magiera-Mularz, Benedykt Wladyka, Grzegorz Dubin, Jacek Plewka, Justyna Kocik, Kazimierz Weglarczyk, Małgorzata Stec, Lukasz Skalniak, Bogdan Musielak, Przemyslaw Grudnik, Katarzyna Kuska, Maciej Siedlar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c76cc20b42efff5f1685b0af242ab16
https://ruj.uj.edu.pl/xmlui/handle/item/267441
https://ruj.uj.edu.pl/xmlui/handle/item/267441