Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Przemysław B. Radwański"'
Autor:
Mikhail Tarasov, Heather L. Struckman, Yusuf Olgar, Alec Miller, Mustafa Demirtas, Vladimir Bogdanov, Radmila Terentyeva, Andrew M. Soltisz, Xiaolei Meng, Dennison Min, Galina Sakuta, Izabella Dunlap, Antonia D. Duran, Mark P. Foster, Jonathan P. Davis, Dmitry Terentyev, Sándor Györke, Rengasayee Veeraraghavan, Przemysław B. Radwański
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Calmodulin (CaM) plays critical roles in cardiomyocytes, regulating Na+ (NaV) and L-type Ca2+ channels (LTCCs). LTCC dysregulation by mutant CaMs has been implicated in action potential duration (APD) prolongation and arrhythmogenic long QT (LQT) syn
Externí odkaz:
https://doaj.org/article/81e38ae2959b485889b6727a408e1abd
Autor:
Louisa Mezache, Heather L. Struckman, Amara Greer-Short, Stephen Baine, Sándor Györke, Przemysław B. Radwański, Thomas J. Hund, Rengasayee Veeraraghavan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF patients have elevated levels of inflammatory cytokines known to promote vascular leak, such as vascular endothelial growth factor A (VEGF). Howev
Externí odkaz:
https://doaj.org/article/339058eefeee476198027db5f79e00fe
Autor:
Mark A. Munger, Yusuf Olğar, Megan L. Koleske, Heather L. Struckman, Jessica Mandrioli, Qing Lou, Ingrid Bonila, Kibum Kim, Roberto Ramos Mondragon, Silvia G. Priori, Pompeo Volpe, Héctor H. Valdivia, Joseph Biskupiak, Cynthia A. Carnes, Rengasayee Veeraraghavan, Sándor Györke, Przemysław B. Radwański
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 11 (2020)
Background Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca2+‐dependent nature of both of these pathologies, AF often responds to Na+ channel blockers.
Externí odkaz:
https://doaj.org/article/c3b12da609534a84822dec8d477ebd3b
Autor:
Przemysław B. Radwański, PharmD, PhD, Hsiang-Ting Ho, PhD, Rengasayee Veeraraghavan, PhD, Lucia Brunello, PhD, Bin Liu, PhD, Andriy E. Belevych, PhD, Sathya D. Unudurthi, PhD, Michael A. Makara, PhD, Silvia G. Priori, MD, PhD, Pompeo Volpe, PhD, Antonis A. Armoundas, PhD, Wolfgang H. Dillmann, MD, Bjorn C. Knollmann, MD, PhD, Peter J. Mohler, PhD, Thomas J. Hund, PhD, Sándor Györke, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 4, Pp 251-266 (2016)
Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the sub
Externí odkaz:
https://doaj.org/article/14f969abcf034b40ad9a83088e11255d
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
A nanodomain is a collection of proteins localized within a specialized, nanoscale structural environment, which can serve as the functional unit of macroscopic physiologic processes. We are beginning to recognize the key roles of cardiomyocyte nanod
Externí odkaz:
https://doaj.org/article/43be401a135743119b5b7f0d0ffcc398
Autor:
Bin Liu, Shane D. Walton, Hsiang‐Ting Ho, Andriy E. Belevych, Svetlana B. Tikunova, Ingrid Bonilla, Vikram Shettigar, Bjorn C. Knollmann, Silvia G. Priori, Pompeo Volpe, Przemysław B. Radwański, Jonathan P. Davis, Sándor Györke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine rece
Externí odkaz:
https://doaj.org/article/17b2d1203c6b4fb18ec412e87dd32e52
Autor:
Heather L. Struckman, Nicolae Moise, D. Ryan King, Andrew Soltisz, Andrew Buxton, Izabella Dunlap, Zhenhui Chen, Przemysław B. Radwański, Seth H. Weinberg, Rengasayee Veeraraghavan
Publikováno v:
bioRxiv
During each heartbeat, the propagation of action potentials through the heart coordinates the contraction of billions of individual cardiomyocytes and is thus, a critical life process. Unsurprisingly, intercalated discs, which are cell-cell contact s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51fadc1d61522da2d5e07738dcaed0
https://doi.org/10.1101/2023.02.13.528369
https://doi.org/10.1101/2023.02.13.528369
Autor:
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8607
Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e3187d625b91e0b11b4e75f38bca4d
Autor:
Sandor Gyorke, Stephen Baine, Rengasayee Veeraraghavan, Ingrid M. Bonilla, Przemysław B. Radwański, Marina S. Ivanova, Justin Thomas, Cynthia A. Carnes, Jiaoni Li, Andriy E. Belevych
Publikováno v:
J Biol Chem
Post-translational modifications of proteins involved in calcium handling in myocytes, such as the cardiac ryanodine receptor (RyR2), critically regulate cardiac contractility. Recent studies have suggested that phosphorylation of RyR2 by protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2982c4582a4b291d0a7e5cbdc7ae6aec
https://doi.org/10.1074/jbc.ra120.014054
https://doi.org/10.1074/jbc.ra120.014054
Autor:
Justin Thomas, Louisa Mezache, Stephen Baine, Rengasayee Veeraraghavan, Przemysław B. Radwański, Kirk Mykytyn, Heather Struckman, Sandor Gyorke
Publikováno v:
Microscopy and Microanalysis. 26:157-165
The voltage-gated sodium channel [pore-forming subunit of the neuronal voltage-gated sodium channel (NaV1.6)] has recently been found in cardiac myocytes. Emerging studies indicate a role for NaV1.6 in ionic homeostasis as well as arrhythmogenesis. L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d13bab742012e584d0f79f05f6fb569
https://doi.org/10.1017/s1431927619015289
https://doi.org/10.1017/s1431927619015289