Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Przemek M. Krawczyk"'
Autor:
Sergio Mingo Barba, Fernando Lobo-Cerna, Przemek M. Krawczyk, Marco Lattuada, Rudolf M. Füchslin, Alke Petri-Fink, Stephan Scheidegger
Publikováno v:
Dose-Response, Vol 22 (2024)
Introduction Cell repair dynamics are crucial in optimizing anti-cancer therapies. Various assays (eg, comet assay and γ-H2AX) assess post-radiation repair kinetics, but interpreting such data is challenging and model-based data analyses are require
Externí odkaz:
https://doaj.org/article/f770c92d2a7b4d409b29139a9f6640f9
Autor:
Selami Baglamis, Vivek M. Sheraton, Debora Meijer, Haibin Qian, Ron A. Hoebe, Kristiaan J Lenos, Max A. Betjes, Sander Tans, Jeroen van Zon, Louis Vermeulen, Przemek M. Krawczyk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Clonal growth and competition underlie processes of key relevance in etiology, progression and therapy response across all cancers. Here, we demonstrate a novel experimental approach, based on multi-color, fluorescent tagging of cell nuclei,
Externí odkaz:
https://doaj.org/article/05a85a4d65f946e1b17ffb699bf1566f
Autor:
Jenny Kaur Singh, Rebecca Smith, Magdalena B. Rother, Anton J. L. de Groot, Wouter W. Wiegant, Kees Vreeken, Ostiane D’Augustin, Robbert Q. Kim, Haibin Qian, Przemek M. Krawczyk, Román González-Prieto, Alfred C. O. Vertegaal, Meindert Lamers, Sébastien Huet, Haico van Attikum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZN
Externí odkaz:
https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
Autor:
Haibin Qian, Ron A. Hoebe, Michel R. Faas, Marc Jan van Goethem, Emiel R. van der Graaf, Christoph Meyer, Harry Kiewiet, Sytze Brandenburg, Przemek M. Krawczyk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Cellular responses to DNA double-strand breaks (DSBs) not only promote genomic integrity in healthy tissues, but also largely determine the efficacy of many DNA-damaging cancer treatments, including X-ray and particle therapies. A growing bo
Externí odkaz:
https://doaj.org/article/f53b3751d3154ed185a148a298d26f11
Autor:
Rohit Prakash, Thomas Sandoval, Florian Morati, Jennifer A. Zagelbaum, Pei-Xin Lim, Travis White, Brett Taylor, Raymond Wang, Emilie C. B. Desclos, Meghan R. Sullivan, Hayley L. Rein, Kara A. Bernstein, Przemek M. Krawczyk, Jean Gautier, Mauro Modesti, Fabio Vanoli, Maria Jasin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. Here the authors reveal roles for the mouse SWS1–SWSAP1–SPIDR complex in inter-homolog recombination, including during meiosis, and sister chromat
Externí odkaz:
https://doaj.org/article/1b96dd6800dc4b43afc200198f18973b
Autor:
Teun J. de Vries, Ton Schoenmaker, Henk A. van Veen, Jolanda Hogervorst, Przemek M. Krawczyk, Carolyn G. J. Moonen, Ineke D. C. Jansen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Acquiring immunology laboratory skills during undergraduate studies is often a prerequisite for admission to Masters’ programs. Many broad liberal arts and sciences honors degree colleges struggle in teaching these essentials since only limited tim
Externí odkaz:
https://doaj.org/article/2c59bf22cb70408586a41bdaedc480d4
Autor:
Enzo M. Scutigliani, Edwin R. Scholl, Anita E. Grootemaat, Sadhana Khanal, Jakub A. Kochan, Przemek M. Krawczyk, Eric A. Reits, Atefeh Garzan, Huy X. Ngo, Keith D. Green, Sylvie Garneau-Tsodikova, Jan M. Ruijter, Henk A. van Veen, Nicole N. van der Wel
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multidrug-resist
Externí odkaz:
https://doaj.org/article/57ed75988fc9476a83114ff066bc32be
Autor:
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy I. Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Publikováno v:
Cancers, 14(21):5250. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers; Volume 14; Issue 21; Pages: 5250
Cancers; Volume 14; Issue 21; Pages: 5250
Hyperthermia is being used as a radio- and chemotherapy sensitizer for a growing range of tumor subtypes in the clinic. Its potential is limited, however, by the ability of cancer cells to activate a protective mechanism known as the heat stress resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d50a4880dffeeb81fc955ae73e2fa6
https://pure.amc.nl/en/publications/evaluation-of-the-heat-shock-protein-90-inhibitor-ganetespib-as-a-sensitizer-to-hyperthermiabased-cancer-treatments(bbb07e88-3cd7-4c56-859d-f5edddd25274).html
https://pure.amc.nl/en/publications/evaluation-of-the-heat-shock-protein-90-inhibitor-ganetespib-as-a-sensitizer-to-hyperthermiabased-cancer-treatments(bbb07e88-3cd7-4c56-859d-f5edddd25274).html
Autor:
Enzo M. Scutigliani, Fernando Lobo-Cerna, Sergio Mingo Barba, Stephan Scheidegger, Przemek M. Krawczyk
Publikováno v:
Cancers
Hyperthermia is clinically applied cancer treatment in conjunction with radio- and/or chemotherapy, in which the tumor volume is exposed to supraphysiological temperatures. Since cells can effectively counteract the effects of hyperthermia by protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f374539b06e1c357d06c1e8b1e212be
Autor:
Christoph F. J. Meyer, Haibin Qian, Harry Kiewiet, Sytze Brandenburg, Przemek M. Krawczyk, Emiel R van der Graaf, Marc-Jan van Goethem, Ron A. Hoebe, Michel R Faas
Publikováno v:
Scientific reports, 11(1):14528. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports, 11(1):14528. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports, 11(1):14528. Nature Publishing Group
Cellular responses to DNA double-strand breaks (DSBs) not only promote genomic integrity in healthy tissues, but also largely determine the efficacy of many DNA-damaging cancer treatments, including X-ray and particle therapies. A growing body of evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0619283b9251e6d645c91a284a7c8c89
https://doi.org/10.1038/s41598-021-92950-1
https://doi.org/10.1038/s41598-021-92950-1