Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

Autor: Pryor, Rosina, Norvaisas, Povilas, Marinos, Georgios, Best, Lena, Thingholm, Louise B., Quintaneiro, Leonor M., de Haes, Wouter, Esser, Daniela, Waschina, Silvio, Lujan, Celia, Smith, Reuben L., Scott, Timothy A., Martinez-Martinez, Daniel, Woodward, Orla, Bryson, Kevin, Laudes, Matthias, Lieb, Wolfgang, Houtkooper, Riekelt H., Franke, Andre, Temmerman, Liesbet, Bjedov, Ivana, Cochemé, Helena M., Kaleta, Christoph, Cabreiro, Filipe

Publikováno v: Cell, 178(6), 1299-1312.e29. Cell Press
1312.e29

Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address the fundamental question of how gut microbes and nutrition, key regulators of host physiology, affect the effects of metformin. Co

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https://pure.amc.nl/en/publications/hostmicrobedrugnutrient-screen-identifies-bacterial-effectors-of-metformin-therapy(5a7cf222-7af0-46d1-b856-2b168cc3c1b0).html

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Coupling of Rigor Mortisand Intestinal Necrosis during C. elegansOrganismal Death

Autor: Galimov, Evgeniy R., Pryor, Rosina E., Poole, Sarah E., Benedetto, Alexandre, Pincus, Zachary, Gems, David

Publikováno v: Cell Reports; March 2018, Vol. 22 Issue: 10 p2730-2741, 12p

Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans.

Autor: Coburn, Cassandra, Allman, Erik, Mahanti, Parag, Benedetto, Alexandre, Cabreiro, Filipe, Pincus, Zachary, Matthijssens, Filip, Araiz, Caroline, Mandel, Abraham, Vlachos, Manolis, Edwards, Sally-Anne, Fischer, Grahame, Davidson, Alexander, Pryor, Rosina E., Stevens, Ailsa, Slack, Frank J., Tavernarakis, Nektarios, Braeckman, Bart P., Schroeder, Frank C., Nehrke, Keith

Publikováno v: PLoS Biology; Jul2013, Vol. 11 Issue 7, p1-17, 17p

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Autor: Pryor R; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Norvaisas P; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Marinos G; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Best L; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Thingholm LB; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany., Quintaneiro LM; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., De Haes W; Molecular and Functional Neurobiology, Department of Biology, KU Leuven, 3000 Leuven, Belgium., Esser D; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Waschina S; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Lujan C; UCL Cancer Institute, University College London, London WC1E 6JD, UK., Smith RL; Laboratory of Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Scott TA; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Martinez-Martinez D; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK., Woodward O; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Bryson K; Department of Computer Science, University College London, London WC1E 6BT, UK., Laudes M; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Lieb W; Institute of Epidemiology, Christian Albrechts University Kiel, 24105 Kiel, Germany., Houtkooper RH; Laboratory of Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Franke A; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany., Temmerman L; Molecular and Functional Neurobiology, Department of Biology, KU Leuven, 3000 Leuven, Belgium., Bjedov I; UCL Cancer Institute, University College London, London WC1E 6JD, UK., Cochemé HM; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK., Kaleta C; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany. Electronic address: c.kaleta@iem.uni-kiel.de., Cabreiro F; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK. Electronic address: f.cabreiro@lms.mrc.ac.uk.

Publikováno v: Cell [Cell] 2019 Sep 05; Vol. 178 (6), pp. 1299-1312.e29. Date of Electronic Publication: 2019 Aug 29.