Safety and efficacy of dexpramipexole in eosinophilic asthma (EXHALE): a randomized controlled trial

Autor: Siddiqui, S, Wenzel, SE, Bozik, ME, Archibald, DG, Dworetzky, SI, Mather, JL, Killingsworth, R, Ghearing, N, Schwartz, JT, Ochkur, SI, Jacobsen, EA, Busse, WW, Panettieri, RA, Prussin, C

BACKGROUND: There is a need for new and effective oral asthma therapies. Dexpramipexole, an oral eosinophil-lowering drug, has not previously been studied in asthma. OBJECTIVE: We sought to evaluate the safety and efficacy of dexpramipexole in loweri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::73e260c767a588262a5d5e8485d79e67
http://hdl.handle.net/10044/1/105271

Urine eosinophil-derived neurotoxin: A potential marker of activity in select eosinophilic disorders.

Autor: Makiya MA; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Khoury P; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Kuang FL; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA.; Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Mata AD; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Mahmood S; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Bowman A; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Espinoza D; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Kovacs N; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Brown T; Clinical Parasitology Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Holland N; Clinical Parasitology Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Wetzler L; Clinical Parasitology Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Ware JM; Clinical Parasitology Section, LPD, NIAID, NIH, Bethesda, Maryland, USA., Dyer AM; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA., Akuthota P; Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, California, USA., Bochner BS; Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Chinchilli VM; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA., Gleich GJ; Departments of Dermatology and Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA., Langford C; Rheumatologic and Immunologic Disease, Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, Ohio, USA., Merkel PA; Division of Rheumatology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Specks U; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA., Weller PF; Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Wechsler ME; Department of Medicine, National Jewish Health, Denver, Colorado, USA., Prussin C; Knopp Biosciences, Pittsburgh, Pennsylvania, USA., Fay MP; Biostatistical Research Branch, NIAID, NIH, Bethesda, Maryland, USA., Klion AD; Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Maryland, USA.

Publikováno v: Allergy [Allergy] 2023 Jan; Vol. 78 (1), pp. 258-269. Date of Electronic Publication: 2022 Sep 01.

Integrative Cross-Talk in Asthma: Unraveling the Complex Interactions Between Eosinophils, Immune, and Structural Cells in the Airway Microenvironment.

Autor: Januskevicius, Andrius¹ (AUTHOR) andrius.januskevicius@lsmu.lt, Vasyle, Egle¹ (AUTHOR) airidas.rimkunas@lsmu.lt, Rimkunas, Airidas¹ (AUTHOR) kestutis.malakauskas@lsmu.lt, Malakauskas, Kestutis^1,2 (AUTHOR)

Publikováno v: Diagnostics (2075-4418). Nov2024, Vol. 14 Issue 21, p2448. 17p.

A Flow Cytometry-Based Examination of the Mouse White Blood Cell Differential in the Context of Age and Sex.

Autor: Arlt, Elise¹ (AUTHOR) andrea.kindermann@uk-halle.de, Kindermann, Andrea¹ (AUTHOR) anne-kristin.fritsche@medizin.uni-leipzig.de, Fritsche, Anne-Kristin^1,2 (AUTHOR) heike.kielstein@uk-halle.de, Navarrete Santos, Alexander³ (AUTHOR) alexander.navarrete@uk-halle.de, Kielstein, Heike¹ (AUTHOR) ivonne.bazwinsky@uk-halle.de, Bazwinsky-Wutschke, Ivonne¹ (AUTHOR)

Publikováno v: Cells (2073-4409). Sep2024, Vol. 13 Issue 18, p1583. 24p.

Interleukin-5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils.

Autor: Buchheit KM; Division of Allergy and Clinical Immunology, AERD Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Shaw D; Department of Respiratory Medicine and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, Leicester, UK., Chupp G; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Lehtimaki L; Faculty of Medicine and Health Technology, Allergy Centre, Tampere University Hospital, Tampere University, Tampere, Finland., Heffler E; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Personalized Medicine, Asthma and Allergy Clinic, IRCCS Humanitas Research Hospital, Milan, Italy., Finney-Hayward T; Global Medical Affairs, Respiratory Specialty Care, GSK, London, UK., Zangrilli J; Clinical Science, GSK, Collegeville, Pennsylvania, USA., Kwiatek J; US Medical Affairs, GSK, Collegeville, Pennsylvania, USA., Siddiqui S; National Heart and Lung Institute, NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK., Roufosse F; Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium., Thamboo A; Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada., West N; School of Pharmacy and Medical Sciences, Griffith University, Southport, Queensland, Australia., Vichiendilokkul A; Clinical Science, GSK, Collegeville, Pennsylvania, USA., Hellings PW; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.; Upper Airways Disease Research Unit, University of Ghent, Ghent, Belgium., Peters A; Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Howarth PH; Global Medical Affairs, Respiratory Specialty Care, GSK, London, UK.

Publikováno v: Allergy [Allergy] 2024 Oct; Vol. 79 (10), pp. 2662-2679.