New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity

Autor: Mitrović, Ana, Senjor, Emanuela, Jukić, Marko, Bolčina, Lara, Prunk, Mateja, Proj, Matic, Nanut, Milica Perišić, Gobec, Stanislav, Kos, Janko

Publikováno v: In Computational and Structural Biotechnology Journal 2022 20:4667-4687

Vloga cistatina F in cisteinskih katepsinov pri delovanju citotoksičnih limfocitov T

Autor: Prunk, Mateja

Citotoksični limfociti T CD8+ (CTL) in naravne celice ubijalke (celice NK) imajo ključno vlogo v imunskem odzivu proti celicam, okuženim z virusi in proti rakavim celicam, saj jih lahko neposredno ubijejo. CTL in celice NK se bistveno razlikujejo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3505::2e97c1f325a40bca7daca99171cff382
https://hdl.handle.net/20.500.12556/RUL-137320

Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 - Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes

Autor: Schlichtner, Stephanie, Yasinska, Inna M, Ruggiero, Sabrina, Berger, Steffen M, Aliu, Nijas, Prunk, Mateja, Kos, Janko, Meyer, N Helge, Gibbs, Bernhard F, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

Publikováno v: Schlichtner, Stephanie; Yasinska, Inna M; Ruggiero, Sabrina; Berger, Steffen M; Aliu, Nijas; Prunk, Mateja; Kos, Janko; Meyer, N Helge; Gibbs, Bernhard F; Fasler-Kan, Elizaveta; Sumbayev, Vadim V (2022). Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1-Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes. Frontiers in medicine, 9, p. 790995. Frontiers 10.3389/fmed.2022.790995

Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of blocking th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3071::6b035b6b2f29b0208cc85fcd17e7adee
https://boris.unibe.ch/166212/1/fmed-09-790995.pdf

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The fungal Clitocybe nebularis lectin binds distinct cell surface glycoprotein receptors to induce cell death selectively in Jurkat cells.

Autor: Perišić Nanut, Milica, Žurga, Simon, Konjar, Špela, Prunk, Mateja, Kos, Janko, Sabotič, Jerica

Publikováno v: FASEB Journal; Apr2022, Vol. 36 Issue 4, p1-20, 20p