Extravascular Transport of Drugs in Tumor Tissue:  Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures

Autor: Pruijn, F. B., Sturman, J. R., Liyanage, H. D. S., Hicks, K. O., Hay, M. P., Wilson, W. R.

Publikováno v: Journal of Medicinal Chemistry; February 2005, Vol. 48 Issue: 4 p1079-1087, 9p

Effect of Nitroreduction on the Alkylating Reactivity and Cytotoxicity of the 2,4-Dinitrobenzamide-5-aziridine CB 1954 and the Corresponding Nitrogen Mustard SN 23862:  Distinct Mechanisms of Bioreductive Activation

Autor: Helsby, N. A., Wheeler, S. J., Pruijn, F. B., Palmer, B. D., Yang, S., Denny, W. A., Wilson, W. R.

Publikováno v: Chemical Research in Toxicology; April 2003, Vol. 16 Issue: 4 p469-478, 10p

Abstracts of papers medicinal chemical meeting

Autor: Damsma, G., Westerink, B. H. C., de Vries, J. B., Horn, A. S., Rettenmayr, N., de Miranda, J. F. Rodrigues, Lambrecht, G., Mutschler, E., Russel, F. G. M., van Galen, P. J. M., van Viijmen, H. W. Th., Ijzerman, A. P., Soudijn, W., Vromans, R. M., van de Straat, R., Groeneveld, M., Vermeiden, N. P. E., Siero, H. L. M., van Zwam, A. J. G., de Miranda, J. F. Rodriques, van Ginneken, C. A. M., Willems, P. H. G. M., de Pont, J. J. H. H. M., van Gelderen, J. G., Pruijn, F. B., Bast, A., de Zwart, M. A. H., van der Goot, H., Timmerman, H., Kramer, K., Voss, H. P., Grimbergen, J. A., Goeptar, A. R., Haenen, G. R. M. M., Veerman, M., Vermeulen, N. P. E., Boom, S. P. A., Koper, J. G., Leurs, J. N. L. Go. R., Rekka, E., Sterk, G. J., van der Weide, Jan, Tendijck, H., Tepper, P. G., Horn, A. B., Bosker, F. J., van Bussel, F. J., Plug, M. J., Dijk, J., Tepper, P., Möller, W., Leusen, F. J. J., van Vlijmen, H. W. Th., de Kaste, D., van Amsterdam, J. G. C., Llorens-Cortes, C., Vleeming, W., v. d. Wouw, P. A., v. Rooij, H. H., Wemer, J., Porsius, A. J., Lusthof, K. J., de Mol, N. J., Janssen, L. H. M., Bakri, Aziz, Janssen, Lambert H. M., Wilting, Jaap, Kelder, P. P., Kuit, M. C. A. W., van Sterkenburg, E. L. M., Wilting, J., Bos, O. J. M., Fischer, M. J. E.

Publikováno v: Pharmacy World & Science; December 1987, Vol. 9 Issue: 6 p338-345, 8p

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Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells.

Autor: Hicks KO; Auckland Cancer Society Research Centre, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand. k.hicks@auckland.ac.nz, Pruijn FB, Baguley BC, Wilson WR

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2001 Jun; Vol. 297 (3), pp. 1088-98.