Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Prudencio Herradura"'
Autor:
J.V.N. Vara Prasad, Michael R. Dermyer, Michael D. Huband, Adam R. Renslo, Andy Atuegbu, Karen L. Leach, Prudencio Herradura, Priyadarshini Jaishankar, Mikhail F. Gordeev, Luping Wu, Mingzhe Ji
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5036-5040
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis in
Autor:
Jared Silverman, Prudencio Herradura, Yong He, Judith N. Steenbergen, Andrew D. G. Van Praagh, Lawrence I. Mortin, Ning Yin, Michael F. Mesleh, Andre Lee Pearson, Jing Li, Diane Citron, Carmela T. M. Mascio, Dennis Keith, Chester Metcalf, Grace M. Thorne, Karen Howland
Publikováno v:
Journal of medicinal chemistry. 58(12)
Novel cyclic lipopeptides with different acyl tails were synthesized via a semisynthetic approach. Structure–activity relationship studies revealed that lipophilicity, chain length, and the location of key aromatic functionalities of the tail modul
Autor:
Peter A. Jacobi, Prudencio Herradura
Publikováno v:
Canadian Journal of Chemistry. 79:1727-1735
(+)- and ()-Nephrosteranic acid (16) have been prepared in an enantioselective fashion from alkyne acid 19 (or ent-19) by a three step sequence involving debenzylationlactonization, oxidative cleavage, and selective epimerization at C4. Acids 19
Autor:
Prudencio Herradura, Peter A. Jacobi
Publikováno v:
Tetrahedron Letters. 38:6621-6624
(−)-Blastmycinolactol ( 1b ) has been prepared in an enantioselective fashion from acetylenic acid 5 by a three step sequence involving debenzylation-lactonization, hydration with concurrent C 3 -epimerization, and Baeyer-Villiger oxidation accompa
Autor:
Peter A. Jacobi, Prudencio Herradura
Publikováno v:
Tetrahedron Letters. 37:8297-8300
(+)- and (−)-Phaseolinic acid ( 1 ) have been prepared in an enantioselective fashion from acetylenic acid 26 (or ent- 26 ) by a three step sequence involving lactonization, epimerization at C 3 , and oxidative cleavage. 26 was obtained as a single
Autor:
Prudencio Herradura, Peter A. Jacobi
Publikováno v:
ChemInform. 28
(+)- and (−)-Phaseolinic acid ( 1 ) have been prepared in an enantioselective fashion from acetylenic acid 26 (or ent- 26 ) by a three step sequence involving lactonization, epimerization at C 3 , and oxidative cleavage. 26 was obtained as a single
Autor:
Peter A. Jacobi, Prudencio Herradura
Publikováno v:
ChemInform. 28
(−)-Blastmycinolactol ( 1b ) has been prepared in an enantioselective fashion from acetylenic acid 5 by a three step sequence involving debenzylation-lactonization, hydration with concurrent C 3 -epimerization, and Baeyer-Villiger oxidation accompa
Autor:
Zhengyu Yuan, Bore Raju, Marcela Gomez, Joaquim Trias, Hardwin O'dowd, Bum Tae Kim, Prudencio Herradura, Dinesh V. Patel, Shihai Gu, Richard C. White, Wen Wang, Sampath-Kumar Anandan, Charlotte Wu, C J Hackbarth
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(12)
Deoxynegamycin (1b) is a protein synthesis inhibitor with activity against Gram-negative (GN) bacteria. A series of conformationally restricted analogs were synthesized to probe its bioactive conformation. Indeed, some of the constrained analogs were