Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Prox, Johannes"'
Autor:
Petrowitz Bettina, Jorissen Ellen, Thurm Dana, Bernreuther Christian, Kluth Mark A, Puig Berta, Prox Johannes, Altmeppen Hermann C, Bartsch Udo, De Strooper Bart, Saftig Paul, Glatzel Markus
Publikováno v:
Molecular Neurodegeneration, Vol 6, Iss 1, p 36 (2011)
Abstract Background The cellular prion protein (PrPC) fulfils several yet not completely understood physiological functions. Apart from these functions, it has the ability to misfold into a pathogenic scrapie form (PrPSc) leading to fatal transmissib
Externí odkaz:
https://doaj.org/article/b6e18e3740224ec4a8f8d805102c79c6
Autor:
Prox, Johannes1, Saftig, Paul2
Publikováno v:
Neuroforum. Jun2014, Vol. 20 Issue 2, p212-221. 10p.
Autor:
Altmeppen, Hermann C.1, Prox, Johannes2, Puig, Berta1, Dohler, Frank1, Falker, Clemens1, Krasemann, Susanne1, Glatzel, Markus1
Publikováno v:
FEBS Journal. Sep2013, Vol. 280 Issue 18, p4338-4347. 10p.
Autor:
Altmeppen, Hermann C.1, Prox, Johannes2, Puig, Berta1, Kluth, Mark A3, Bernreuther, Christian1, Thurm, Dana1, Jorissen, Ellen4,5, Petrowitz, Bettina6, Bartsch, Udo6, De Strooper, Bart4,5, Saftig, Paul2, Glatzel, Markus1 m.glatzel@uke.de
Publikováno v:
Molecular Neurodegeneration. 2011, Vol. 6 Issue 1, p36-47. 12p.
Autor:
Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Wichert, Rielana, Prox, Johannes, Altmeppen, Hermann, Kumar, Sathish, Walter, Jochen, Lichtenthaler, Stefan F., Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus
Publikováno v:
Molecular Neurodegeneration
Molecular neurodegeneration 11(1), 19 (2016). doi:10.1186/s13024-016-0084-5
Molecular neurodegeneration 11(1), 19 (2016). doi:10.1186/s13024-016-0084-5
Background The metalloprotease meprin β cleaves the Alzheimer’s Disease (AD) relevant amyloid precursor protein (APP) as a β-secretase reminiscent of BACE-1, however, predominantly generating N-terminally truncated Aβ2-x variants. Results Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b3ffc0bea4e42c4722b52d80dd5991
http://europepmc.org/articles/PMC4759862
http://europepmc.org/articles/PMC4759862
Autor:
Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Rielana Wichert, Prox, Johannes, Altmeppen, Hermann, Sathish Kumar, Walter, Jochen, Lichtenthaler, Stefan, Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus
Meprin β prefers cleavage of wt APP compared to APP A673T. 15 nM recombinant meprin β was incubated with synthetic APP peptides for different time intervals. HPLC analysis showed that processing kinetics of APP A376T (F-J) were decreased compared t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42a1a0e20642d003928322ad3075c40
Autor:
Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Rielana Wichert, Prox, Johannes, Altmeppen, Hermann, Sathish Kumar, Walter, Jochen, Lichtenthaler, Stefan, Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus
APP A673T mutation protects from meprin β mediated cleavage. HEK-293 T cells were transiently transfected with APPwt or APP A673T mutant and co-transfected with the empty vector or meprin β. 24 h post transfection supernatants were immunoprecipitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6adfa9f887c9c83a6d643ef2e355c8a
Autor:
Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Rielana Wichert, Prox, Johannes, Altmeppen, Hermann, Sathish Kumar, Walter, Jochen, Lichtenthaler, Stefan, Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus
APP and meprin β colocalize in the secretory pathway and at the cell surface. HEK cells were co-transfected with APP-GFP and meprin β-dsRed. Both proteins predominantly colocalize in the cis-golgi compartment. Colocalization in early endosomes was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e30d1b133023547e94162800ce6e8bb
Autor:
Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Rielana Wichert, Prox, Johannes, Altmeppen, Hermann, Sathish Kumar, Walter, Jochen, Lichtenthaler, Stefan, Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus
Antibodies 192wt and 7a6 only detect sAPP in brain soluble fractions of wildtype mice. To test the specificity of the antibodies 7A6 and 192wt we compared brain soluble fractions of wildtype and APP ko mice. Here, we could show that by using the corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8cf506ffdd2aa197d4473353666c69
Autor:
Schönherr, Caroline, Bien, Jessica, Isbert, Simone, Rielana Wichert, Prox, Johannes, Altmeppen, Hermann, Sathish Kumar, Walter, Jochen, Lichtenthaler, Stefan, Weggen, Sascha, Glatzel, Markus, Becker-Pauly, Christoph, Pietrzik, Claus
ADAM10 protein levels are not altered in Mep1b−/− animals. To exclude that the lack of meprin β has any effect on ADAM10 levels, which could affect sAPP levels, we analyzed lysates of whole brains from 16 week old Mep1b−/− and wt animals via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f6243bafa9c8ffd25d0000fe6504c8