Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Prouty Catherine P"'
Autor:
Gilbert Moachon, Lars J. S. Knutsen, Nadine C. Becknell, Mark A. Ator, Joanne R. Mathiasen, Lisa D. Aimone, Rita Raddatz, Michael J. Marino, Robert L. Hudkins, Michael Williams, Mehran Yazdanian, Edward R. Bacon, John P. Mallamo, Prouty Catherine P, Ming Tao
Publikováno v:
Journal of Medicinal Chemistry. 54:4781-4792
Optimization of a novel series of pyridazin-3-one histamine H(3) receptor (H(3)R) antagonists/inverse agonists identified 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (8a, CEP-26401; irdabisant) as a lead candidate for poten
Publikováno v:
Journal of Heterocyclic Chemistry. 38:1003-1006
This report describes an improved synthesis of enantiomerically pure (S)-2-[4-(Dimethylamino)phenyl]-2,3-dihydro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)-phenyl]-1-piperazinyl]propyl]-1,3-dioxo-1H-isoindole-5-carboxamide (RWJ 69442), a potent and select
Autor:
Virginia L. Pulito, Mary Evangelisto, Sally S. Varga, Peter K. Cheung, Linda K. Jolliffe, William V. Murray, Prouty Catherine P, Jian Wang, Gee-Hong Kuo
Publikováno v:
Journal of Medicinal Chemistry. 43:2183-2195
Beginning from the screening hit and literature alpha(1)-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective alpha(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibil
Autor:
Prouty Catherine P, Roland E. Dolle, Joost Strastes, Mark A. Ator, Speier Gary J, Carla T. Helaszek, Hoyer Denton W, Todd L. Graybill, Joanne Uhl
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:41-46
Aryl-substituted tetronic acids, tetramic acids, and cyclic β-dicarbonyl moieties were evaluated as leaving groups in the peptidyl-COCH2-X type inhibitor iii. Tripeptidyl aspartyl α-((tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone derivatives
Autor:
Hoyer Denton W, Schmidt Stanley J, Roland E. Dolle, C. V. C. Prasad, I. Kelly Osifo, Mark A. Ator, Carla T. Helaszek, Prouty Catherine P, Mohamad M. A. Awad, Tina Morgan Ross, Robert E. Miller, Salvino Joseph M, Todd L. Graybill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:315-318
Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P 2 and P 3 positions. It appears th
Autor:
A. Yawman, T.J. Caulfield, W.C. Schairer, C.V.C. Prasad, Prouty Catherine P, Ashis K. Saha, L. I. Kruse, D. A. Upson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:411-414
A stereoselective method for the synthesis of 3′-α-or 3′-β-carbon substituted pyrimidine nucleosides was developed. The synthesis of the CH 2 NHCH 2 linkage is described. The linkage offers enhanced resistance to 3′-exonuclease.
Autor:
D. A. Upson, T.J. Caulfield, Prouty Catherine P, C.V.C. Prasad, D.J. Delecki, Ashis K. Saha, L. I. Kruse
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1497-1500
The synthesis of an O-CH2-CH2 internucleoside linkage has been achieved. The crucial carbon to oxygen bond was formed by trapping a π-allyl palladium complex with 3' alcohol6. An antisense oligonucleoside containing this dimer modification hybridize
Autor:
D. A. Upson, W.C. Schairer, L. I. Kruse, M. Sardaro, T.J. Caulfield, Ashis K. Saha, C.V.C. Prasad, A. Yawman, Prouty Catherine P
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2771-2776
The synthesis of CH2-CH2-NH and NH-CH2-CH2 internucleoside linkages are described. Antisense oligonucleosides containing these dimer modifications hybridized to the sense sequence. Furthermore incorporation of these backbone modifications enhanced th
Publikováno v:
ChemInform. 32
This report describes an improved synthesis of enantiomerically pure (S)-2-[4-(Dimethylamino)phenyl]-2,3-dihydro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)-phenyl]-1-piperazinyl]propyl]-1,3-dioxo-1H-isoindole-5-carboxamide (RWJ 69442), a potent and select
Autor:
Wang, Aihua, Prouty, Catherine P., Pelton, Patricia D., Yong, Maria, Demarest, Keith T., Murray, William V., Kuo, Gee-Hong
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(4):1432-1435