Nexrutine® preserves muscle mass similar to exercise in prostate cancer mouse model

Autor: Darpan I. Patel, Derek Wallace, Kira Abuchowski, Paul Rivas, Amber Gallegos, Nicolas Musi, Addanki Pratap. Kumar

Publikováno v: Physiological Reports, Vol 7, Iss 16, Pp n/a-n/a (2019)

Abstract Muscle loss is a debilitating side effect to prostate cancer (PCa) experienced by nearly 60% of men. The purpose of this study was to test the hypothesis that Nexrutine®, a bark extract from the Phellodendrum amurense, can protect against p

Externí odkaz: https://doaj.org/article/00bf1b87b0fa4220a62981c7a6f3ecd8

Redução do crescimento e resistência celular de carcinoma mamário após silenciamento do gene PIF/DCD (Proteolysis-Inducing Factor) via shRNAi.

Autor: Moreira, Dayson Friaça

A expressão do PIF/DCD em tumores tem sido relacionada ao crescimento e resistência à morte celular e à indução de caquexia em camundongos. O objetivo deste estudo foi investigar o papel do PIF/DCD nestes processos. Foram construídos três PIF

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/42/42136/tde-18102007-144836/

The Janus-Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts

Autor: Mohamad Assi, Amélie Rébillard

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Hindawi, 2016, 2016, pp.1-19. ⟨10.1155/2016/9579868⟩
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Oxidative Medicine and Cellular Longevity, 2016, 2016, pp.1-19. ⟨10.1155/2016/9579868⟩

International audience; Chronic inflammation and excessive loss of skeletal muscle usually occur during cancer cachexia, leading to functional impairment and delaying the cure of cancer. The release of cytokines by tumor promotes the formation of rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1052cba4bebbb3ce16d7fd27eb948b62
https://doi.org/10.1155/2016/9579868

Catabolic mediators of cancer cachexia

Autor: Michael J. Tisdale

Publikováno v: Current Opinion in Supportive & Palliative Care. 2:256-261

This review compares the catabolic actions of tumour necrosis factor-alpha (TNF-alpha) and proteolysis-inducing factor (PIF) and their involvement in human cancer cachexia.TNF-alpha has a direct catabolic effect on skeletal muscle and adipose tissue,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628d3cf6b6e9413568bb6c243b41235e
https://doi.org/10.1097/spc.0b013e328319d7fa

NF-κB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitin–proteasome system in skeletal muscle

Autor: Michael J. Tisdale, Stacey M. Wyke

Publikováno v: British Journal of Cancer

Loss of skeletal muscle in cancer cachexia has a negative effect on both morbidity and mortality. The role of nuclear factor-kappaB (NF-kappaB) in regulating muscle protein degradation and expression of the ubiquitin-proteasome proteolytic pathway in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd2ed0ceffd0697710633273a68da78
http://europepmc.org/articles/PMC2361865