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pro vyhledávání: '"Proteolipid Protein 1"'
Akademický článek
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Autor:
Tatyana Strekalova, Evgeniy Svirin, Ekaterina Veniaminova, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W.Y. Yung, Andrey Proshin, Susanne Walitza, Daniel C. Anthony, Lee Wei Lim, Klaus-Peter Lesch, Eugene D. Ponomarev
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100306- (2021)
Gangliosides are glycosphingolipids, which are abundant in brain, are known to modulate ion channels and cell-to-cell communication. Deficiencies can result in aberrant myelination and altered immune responses, which can give rise to neurodevelopment
Externí odkaz:
https://doaj.org/article/8608672414da4f6d81d931281e3c4f30
Autor:
Guy Khalaf, Claudia Mattern, Mélina Begou, Odile Boespflug-Tanguy, Charbel Massaad, Liliane Massaad-Massade
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1709 (2022)
Pelizaeus–Merzbacher Disease (PMD) is an inherited leukodystrophy affecting the central nervous system (CNS)—a rare disorder that especially concerns males. Its estimated prevalence is 1.45–1.9 per 100,000 individuals in the general population.
Externí odkaz:
https://doaj.org/article/5e20e7ca452f460d97555da82facb8f1
Autor:
Francesco Nicita, Chiara Aiello, Gessica Vasco, Massimiliano Valeriani, Fabrizia Stregapede, Andrea Sancesario, Michela Armando, Enrico Bertini
Publikováno v:
Brain Sciences, Vol 11, Iss 1, p 93 (2021)
The PLP1 gene, located on chromosome Xq22, encodes the proteolipid protein 1 and its isoform DM20. Mutations in PLP1 cause a spectrum of white matter disorders of variable severity. Here we report on four additional HEMS patients from three families
Externí odkaz:
https://doaj.org/article/24785986051b4fb58dd5d26cd1319f97
Autor:
Masanosuke Kinoshita, William Roston
Publikováno v:
Journal of Nepal Medical Association, Vol 56, Iss 214 (2018)
Pelizaeus Merzbacher Disease (PMD) is a rare X-linked central nervous system (CNS) disease involving the proteolipid protein 1 (PLP1) gene. Patients exhibit signs for instance nystagmus, hypotonia, ataxia. We report a three year old female patient wi
Externí odkaz:
https://doaj.org/article/a66c7397dfdd437a802007165b9f6052
Autor:
Shu Xu, Jian Liu, Hua Yang, Yaxin Hu, Jun Jia, Xuelin Zhang, Zhirui Zeng, Liangzhao Chu, Niya Long, Yushi Yang
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 6643-6654 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 1, Pp 6643-6654 (2021)
Glioblastoma multiforme (GBM) is the most common primary intracranial malignancy in adults. Owing to individual tolerance and tumor heterogeneity, the therapy methods for young adults do not apply to older adults. The present study aimed to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af39c82d853a046389166579ec45c1c8
http://europepmc.org/articles/PMC8806527
http://europepmc.org/articles/PMC8806527
Autor:
Ashish Patel, Kyle S. Saitta, Cheryl F. Dreyfus, Lauren D. Lercher, Yangyang Huang, Geoffrey McAuliffe, Danielle M. Sainato
Publikováno v:
Glia
It is well recognized that astrocytes can produce factors known to affect the myelination process. One such factor, brain-derived neurotrophic factor (BDNF), can enhance the differentiation of oligodendrocyte lineage cells following a demyelinating l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8913c304788da9486a694431f3942c
https://doi.org/10.1002/glia.24003
https://doi.org/10.1002/glia.24003
Autor:
Byung Park, Dennis Bourdette, Steven G. Kohama, Samuel M. Peterson, Betsy Ferguson, Ian J. Tagge, Michael K. Axthelm, Larry S. Sherman, Kristin S. Fitzpatrick, Aparna N. Govindan, Scott W. Wong, William D. Rooney, Minsha Manoharan, Grayson S. Wong
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 456-470 (2021)
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology
Objective To determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and periphery. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2a64809d2ce2a31bee447f2fd6f650
https://doaj.org/article/e3983dd963594c35b1d381ed7a651083
https://doaj.org/article/e3983dd963594c35b1d381ed7a651083
Autor:
Lei Wu, Jian Wang, Qulian Guo, Zhigang Cheng, Zhong Zhang, Yunjiao Wang, Yanping Jian, Zongbin Song, E Wang
Publikováno v:
Toxicology Letters. 336:1-10
Lidocaine induces neurotoxicity in the spinal cord, but the underlying mechanisms remain unclear. In this study, we evaluated the effects of miR-199a-5p on 10 % lidocaine neurotoxicity. Increased expression of miR-199a-5p in the spinal cord of rats t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071d8d6c2072b98fa4e2de77fdf9b4b3
https://doi.org/10.1016/j.toxlet.2020.11.001
https://doi.org/10.1016/j.toxlet.2020.11.001
Autor:
Bruce A. Rheaume, Gwendolyn Schultz, Royce Mohan, Paola Bargagna-Mohan, Sonali Pal-Ghosh, Mary Ann Stepp, Ephraim F. Trakhtenberg, Paul Robson, Wendy B. Macklin, Katherine S. Given
Publikováno v:
Journal of Neuroscience Research
The cornea is the most innervated tissue in the human body. Myelinated axons upon inserting into the peripheral corneal stroma lose their myelin sheaths and continue into the central cornea wrapped by only nonmyelinating corneal Schwann cells (nm‐c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ce6a148bbbaf19b361fd8b2db04265
https://doi.org/10.1002/jnr.24757
https://doi.org/10.1002/jnr.24757