Výsledky vyhledávání - "Proteoglycan binding"

Akademický článek

Assessment of Possible Contributions of Hyaluronan and Proteoglycan Binding Link Protein 4 to Differential Perineuronal Net Formation at the Calyx of Held

Autor: Kojiro Nojima, Haruko Miyazaki, Tetsuya Hori, Lydia Vargova, Toshitaka Oohashi

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The calyx of Held is a giant nerve terminal mediating high-frequency excitatory input to principal cells of the medial nucleus of the trapezoid body (MNTB). MNTB principal neurons are enwrapped by densely organized extracellular matrix structures, kn

Externí odkaz: https://doaj.org/article/06ef2e0ecc8848e4bd342608259f7581

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Akademický článek

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Akademický článek

Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients

Autor: Osman Ahmed, Karin Littmann, Ulf Gustafsson, Camilla Pramfalk, Katariina Öörni, Lilian Larsson, Mirko E. Minniti, Staffan Sahlin, German Camejo, Paolo Parini, Mats Eriksson

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 24 (2018)

Background In randomized trials (SHARP [Study of Heart and Renal Protection], IMPROVE‐IT [Improved Reduction of Outcomes: Vytorin Efficacy International Trial]), combination of statin and ezetimibe resulted in additional reduction of cardiovascular

Externí odkaz: https://doaj.org/article/288d0fb803c24c84b43d61aa5ebe9657

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Akademický článek

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Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins

Autor: Mari Lahelma, Martina B. Lorey, Leanne Hodson, Katariina Öörni, Panu K. Luukkonen, Hannele Yki-Järvinen, Sami Qadri, Petri T. Kovanen, Sanja Sädevirta, Tuulia Hyötyläinen, Maija Ruuth

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology

Supplemental Digital Content is available in the text.
Objective: We recently showed that measurement of the susceptibility of LDL (low-density lipoprotein) to aggregation is an independent predictor of cardiovascular events. We now wished to co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be5d9ab5a644d63a6681383df7d76e0
https://doi.org/10.1161/atvbaha.120.315766

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Akademický článek

Elevated Hapln2 expression contributes to protein aggregation and neurodegeneration in an animal model of Parkinson's disease

Autor: Qinqin Wang, Qinbo Zhou, Shuzhen Zhang, Wei Shao, Yanqing Yin, Yandong Li, Jincan Hou, Xinhua Zhang, Yongshun Guo, Xiaomin Wang, Xiaosong Gu, Jiawei Zhou

Publikováno v: Frontiers in Aging Neuroscience, Vol 8 (2016)

Parkinson’s disease (PD), the second most common age-associated progressive neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SN). The pathogenesis of PD and the mechanisms

Externí odkaz: https://doaj.org/article/cadf3683b0ee43c990e8a45f41d6361a

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Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2

Autor: Grober Baltazar, Anais K. Amaya, Antonette Bennett, Erhua Zhu, Leszek Lisowski, Adrian J. Thrasher, Sophia H.Y. Liao, Renina Gale Navarro, Marti Cabanes-Creus, Mavis Agbandje-McKenna, Ian E. Alexander, Giorgia Santilli, Arkadiusz Rybicki, Suzanne Scott, Erwan Sallard, Matthieu Drouyer, Adrian Westhaus, Claus V. Hallwirth, Kimberley L. Dilworth

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 1139-1154 (2020)

Use of the prototypical adeno-associated virus type 2 (AAV2) capsid delivered unexpectedly modest efficacy in an early liver-targeted gene therapy trial for hemophilia B. This result is consistent with subsequent data generated in chimeric mouse-huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc148bb3a6bcf2b038644a4c8873caa
http://www.sciencedirect.com/science/article/pii/S2329050120300917

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Proteoglycan binding as proatherogenic function metric of apoB-containing lipoproteins and chronic kidney graft failure

Autor: Steffen, Hannah L. M., Anderson, Josephine L. C., Poot, Margot L., Lei, Yu, Connelly, Margery A., Bakker, Stephan J. L., Oorni, Katariina, Tietge, Uwe J. F.

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100083-(2021)
Journal of Lipid Research, 62:100083. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Lipoprotein-proteoglycan binding is an early key event in atherosclerotic lesion formation and thus conceivably could play a major role in vasculopathy-driven chronic graft failure and cardiovascular mortality in renal transplant recipients. The pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e8e7c655712acabcf2220efc6637d0c
http://europepmc.org/articles/PMC8173310

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Akademický článek

Immuno-electron cryo-microscopy imaging reveals a looped topology of apoB at the surface of human LDL[S]

Autor: Yuhang Liu, David Atkinson

Publikováno v: Journal of Lipid Research, Vol 52, Iss 6, Pp 1111-1116 (2011)

A single copy of apoB is the sole protein component of human LDL. ApoB is crucial for LDL particle stabilization and is the ligand for LDL receptor, through which cholesterol is delivered to cells. Dysregulation of the pathways of LDL metabolism is w

Externí odkaz: https://doaj.org/article/630774ab8d854745aaa51d0a3ce3b53f

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