Výsledky vyhledávání - "Protein variation"

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1

Autor: Suchetana Gupta, Ditipriya Mallick, Kumarjeet Banerjee, Shrimon Mukherjee, Soumyadev Sarkar, Sonny TM Lee, Partha Basuchowdhuri, Siddhartha S Jana

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 766-778 (2022)
Computational and Structural Biotechnology Journal

Graphical abstract
The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77e75e84ff2110441d6e92dcaabf7e8
http://www.sciencedirect.com/science/article/pii/S2001037022000241

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Akademický článek

Highlighting Human Enzymes Active in Different Metabolic Pathways and Diseases: The Case Study of EC 1.2.3.1 and EC 2.3.1.9

Autor: Giulia Babbi, Davide Baldazzi, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio

Publikováno v: Biomedicines, Vol 8, Iss 8, p 250 (2020)

Enzymes are key proteins performing the basic functional activities in cells. In humans, enzymes can be also responsible for diseases, and the molecular mechanisms underlying the genotype to phenotype relationship are under investigation for diagnosi

Externí odkaz: https://doaj.org/article/ac59a9543cee4612a54f5b03aceaf177

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Weight and protein variations during the developmental stages of the red flour beetle Tribolium castaneum

Autor: Pranavi Sreeramoju, M.S.K, Prasad, Lakshmipathi, V

Tribolium castaneum, a red flour beetle is now-a-days used as a sophisticated model system for the development and evolutionary studies. As its mode of development is more insect typical than that of Drosophila, Tribolium has become a well-known subj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a3cf237179abcd3fc2475831f54b41

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Whole exome sequencing, in silico and functional studies confirm the association of the GJB2 mutation p.Cys169Tyr with deafness and suggest a role for the TMEM59 gene in the hearing process

Autor: Mona Mahfood, Rania Harati, Jihen Chouchen, Abdullah Al Mutery, Walaa Kamal Eddine Ahmad Mohamed, Abdelaziz Tlili

Publikováno v: Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences, Vol 28, Iss 8, Pp 4421-4429 (2021)

The development of next generation sequencing techniques has facilitated the detection of mutations at an unprecedented rate. These efficient tools have been particularly beneficial for extremely heterogeneous disorders such as autosomal recessive no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64784a76361bd03c51d0cb19e0388e9
http://europepmc.org/articles/PMC8324942

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MutTMPredictor: Robust and accurate cascade XGBoost classifier for prediction of mutations in transmembrane proteins

Autor: Yi-Heng Zhu, Jian Xu Data, Fang Ge, Dong-Jun Yu, Arif Muhammad, Jiangning Song

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6400-6416 (2021)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • Prediction of mutations in transmembrane proteins is of significance for diseases diagnosis. • Building on the evolutionary information, proposed the Gaussian WAPSSM algorithm. • Based on WAPSSM and sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab4583865fc088881c6f516bb043a13
http://www.sciencedirect.com/science/article/pii/S200103702100489X

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In-silico analysis of nonsynonymous genomic variants within CCM2 gene reaffirm the existence of dual cores within typical PTB domain

Autor: Akhil Padarti, Ofek Belkin, Johnathan Abou-Fadel, Jun Zhang

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101218-(2022)

Purpose The objective of this study is to validate the existence of dual cores within the typical phosphotyrosine binding (PTB) domain and to identify potentially damaging and pathogenic nonsynonymous coding single nuclear polymorphisms (nsSNPs) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef96d23ace56c6f3462edfb27158ca35
http://europepmc.org/articles/PMC8808078

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Akademický článek

Efeito da adição de soro de queijo no processo de obtenção de etanol a partir de batata-doce Addition effect of cheese whey in the process of obtaining ethanol from sweet potato

Autor: Isis Prado Meirelles de Castro, Tarso da Costa Alvim, Wesley Rosa de Santana, Valdira Dias Pereira de Carvalho, Marcio Antonio da Silveira

Publikováno v: Ciência e Agrotecnologia, Vol 35, Iss 5, Pp 980-986 (2011)

Estudou-se o incremento na produção convencional de etanol de batata-doce [Ipomoea batatas (L.) Lam.] incorporando soro de queijo ao processo e a variação nos teores de proteína bruta dos resíduos sólidos úmidos gerados por esses processos ut

Externí odkaz: https://doaj.org/article/64c7b8196d3c4ef595b5b0c31896f981

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Solvent Accessibility of Residues Undergoing Pathogenic Variations in Humans: From Protein Structures to Protein Sequences

Autor: Pier Luigi Martelli, Rita Casadio, Matteo Manfredi, Castrense Savojardo

Publikováno v: Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 7 (2021)

Solvent accessibility (SASA) is a key feature of proteins for determining their folding and stability. SASA is computed from protein structures with different algorithms, and from protein sequences with machine-learning based approaches trained on so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacb8042e33abe7b555ef2f7dc89b674
https://doi.org/10.3389/fmolb.2020.626363

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