Zobrazeno 1 - 10
of 2 816
pro vyhledávání: '"Protein translation"'
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract The engineered clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein (Cas) system is currently widely applied in genetic editing and transcriptional regulation. The catalytically inactivated CasRx (dC
Externí odkaz:
https://doaj.org/article/b5ba92a021994fa0a4fb4af6f6d5ec96
Autor:
Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Guptta, Suganya Sakthivel, Wei Wen Teo, Yadanar Than Naing, Kabilesh Arul, Keziah Tikno, Sung-Hee Park, Yajun Wu, Lijin Wang, Boon-Huat Bay, Lei Sun, Vincent Giguere, Pierce K.H. Chow, Sujoy Ghosh, Donald P. McDonnell, Paul M. Yen, Brijesh K. Singh
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101997- (2024)
Objective: Currently, little is known about the mechanism(s) regulating global and specific protein translation during metabolic dysfunction-associated steatohepatitis (MASH; previously known as non-alcoholic steatohepatitis, NASH). Methods: Unbiased
Externí odkaz:
https://doaj.org/article/17f87e3dbde54cfa8579d8857c0fe2d1
Autor:
Álvaro Gómez-Morón, Ilya Tsukalov, Camila Scagnetti, Clara Pertusa, Marta Lozano-Prieto, Pedro Martínez-Fleta, Silvia Requena, Pilar Martín, Aranzazu Alfranca, Enrique Martin-Gayo, Noa B Martin-Cofreces
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCD8+ cytotoxic T lymphocytes (CTLs) are highly effective in defending against viral infections and tumours. They are activated through the recognition of peptide–MHC-I complex by the T-cell receptor (TCR) and co-stimulation. This cognat
Externí odkaz:
https://doaj.org/article/0ac181f7f4fc4d9c8e1b085025124003
Autor:
Rebecca Meyer-Schuman, Allison R. Cale, Jennifer A. Pierluissi, Kira E. Jonatzke, Young N. Park, Guy M. Lenk, Stephanie N. Oprescu, Marina A. Grachtchouk, Andrzej A. Dlugosz, Asim A. Beg, Miriam H. Meisler, Anthony Antonellis
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100324- (2024)
Summary: Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that complete the first step of protein translation: ligation of amino acids to cognate tRNAs. Genes encoding ARSs have been implicated in myriad dominant and re
Externí odkaz:
https://doaj.org/article/74fe00848b15473285079ab25600691e
Autor:
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Panpan Zhang, Jez L. Marston, Tongyi Fei, Manvendra Singh, Cedric Feschotte, Nicholas Collins, Matthew L. Bendall, Douglas F. Nixon
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding fu
Externí odkaz:
https://doaj.org/article/b795fcd1fa0147f6a7b6d5bddd81345f
Autor:
Jianjuan Zhang, Fubo Ji, Yaqi Tan, Lei Zhao, Yongzhi Zhao, Jiaxin Liu, Liyuan Shao, Jiong Shi, Meihua Ye, Xianglei He, Jianping Jin, Bin Zhao, Jun Huang, Stephanie Roessler, Xin Zheng, Junfang Ji
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma‐2 (LAMC2) with important oncogenic roles in iCCA is discovered. In a total of 231 cholangiocarcinoma patients (82
Externí odkaz:
https://doaj.org/article/93b88d3271324f46a375036d2ec012df
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9614 (2024)
Amylin promoter and transcriptional factors are well-established, inducible factors in the production of the main amyloidogenic pancreatic hormone, human islet amyloid peptide (hIAPP) or amylin. However, posttranscriptional mechanisms driving hIAPP e
Externí odkaz:
https://doaj.org/article/9d75eab399dc462c8e993296f582b2d9
Publikováno v:
Animals, Vol 14, Iss 15, p 2227 (2024)
Boar sperm quality serves as an important indicator of reproductive efficiency, playing a direct role in enhancing the output of livestock production. It has been demonstrated that mitochondrial protein translation is present in sperm and plays a cru
Externí odkaz:
https://doaj.org/article/15466039c3ae42c0adfea302f57346c2
Autor:
Yong-Jie Kou, Jin Gao, Rui Li, Zhi-Ya Ma, Hany M. Elsheikha, Xiao-Jing Wu, Xiao-Nan Zheng, Meng Wang, Xing-Quan Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7834 (2024)
Eukaryotic translation initiation factors (eIFs) are crucial for initiating protein translation and ensuring the correct assembly of mRNA-ribosomal subunit complexes. In this study, we investigated the effects of deleting six eIFs in the apicomplexan
Externí odkaz:
https://doaj.org/article/71149be794c04e1fa0954c0ad800af02
Autor:
Joyce Sun, Pete Hwang, Eric D. Sakkas, Yancheng Zhou, Luis Perez, Ishani Dave, Jack B. Kwon, Audrey E. McMahon, Mia Wichman, Mitsu Raval, Kristen Scopino, Daniel Krizanc, Kelly M. Thayer, Michael P. Weir
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5914 (2024)
The central dogma treats the ribosome as a molecular machine that reads one mRNA codon at a time as it adds each amino acid to its growing peptide chain. However, this and previous studies suggest that ribosomes actually perceive pairs of adjacent co
Externí odkaz:
https://doaj.org/article/1e7682c507a54bb69f63a991df6afcd8