Zobrazeno 1 - 10
of 893
pro vyhledávání: '"Protein transduction domain"'
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1776 (2024)
Hepatitis B virus (HBV) infection remains a major health threat with limited treatment options. One of various new antiviral strategies is based on a fusion of Staphylococcus aureus nuclease (SN) with the capsid-forming HBV core protein (HBc), termed
Externí odkaz:
https://doaj.org/article/8062dc1761924874a3646ad76707d6e8
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23488- (2024)
Background: Bain ischemia is a disease that occurs for various reasons, induces reactive oxygen species (ROS), and causes fatal damage to the nervous system. Protective effect of HPCA on ischemic injury has not been extensively studied despite its si
Externí odkaz:
https://doaj.org/article/874e41eb29b449a4a95e2e8c5627840d
Autor:
Jeehye Maeng, Kyunglim Lee
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 3009-3021 (2022)
Our research group reported in 2011 the discovery of a novel cell-penetrating moiety in the N-terminus of the human translationally controlled tumor protein (TCTP). This moiety was responsible for the previously noted membrane translocating ability o
Externí odkaz:
https://doaj.org/article/c3626895eb2943838f9b54fe0514e2ce
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Modern medicine has developed a myriad of therapeutic drugs against a wide range of human diseases leading to increased life expectancy and better quality of life for millions of people. Despite the undeniable benefit of medical advancements in pharm
Externí odkaz:
https://doaj.org/article/bded0362ad074fb094b6269dd39125c7
Autor:
Androulla N. Miliotou, Ioannis S. Pappas, George Spyroulias, Efthimia Vlachaki, Asterios S. Tsiftsoglou, Ioannis S. Vizirianakis, Lefkothea C. Papadopoulou
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 694-710 (2021)
The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through the development of safe and eff
Externí odkaz:
https://doaj.org/article/afd153d731564b958ed59676a877f44c
Autor:
Jeehye Maeng, Kyunglim Lee
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The intranasal route has emerged as a promising strategy that can direct delivery of drugs into the systemic circulation because the high-vascularized nasal cavity, among other advantages, avoids the hepatic first-pass metabolism. The nose-to-brain p
Externí odkaz:
https://doaj.org/article/9f95761fdfb44ee6ae2fa7b38dfb0598
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Yuan Yin, BeiBei Li, Linting Zhou, Jian Luo, Xueying Liu, Shilei Wang, Qun Lu, Wensong Tan, Ze Chen
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1933-1942 (2020)
ABSTRACTThe nucleoprotein (NP) is a highly conserved internal protein of the influenza virus, a major target for universal influenza vaccine. Our previous studies have proven NP-based subunit vaccine can provide partial protection in mice. It is repo
Externí odkaz:
https://doaj.org/article/7c47512fc4134beda381d2567cf5e9db
Autor:
Androulla N. Miliotou, Parthena F. Foltopoulou, Alexandra Ingendoh-Tsakmakidis, Asterios S. Tsiftsoglou, Ioannis S. Vizirianakis, Ioannis S. Pappas, Lefkothea C. Papadopoulou
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 286 (2023)
Mitochondrial disorders represent a heterogeneous group of genetic disorders with variations in severity and clinical outcomes, mostly characterized by respiratory chain dysfunction and abnormal mitochondrial function. More specifically, mutations in
Externí odkaz:
https://doaj.org/article/9409a121f06649b0b969862185ffe7b2
Autor:
Jin-Su Shin, Ilkoo Kim, Jae-Seung Moon, Chun-Chang Ho, Min-Sun Choi, Sankar Ghosh, Sang-Kyou Lee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T helper 17 (TH17) cells are involved in several autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA). In addition to retinoic acid receptor-related orphan nuclear receptor gamma t (ROR-γt), hypoxia-inducible factor-1α
Externí odkaz:
https://doaj.org/article/973874fd7c6b4e59a62379ff1bb1b713