Výsledky vyhledávání - "Protein structure-function"

Akademický článek

Hierarchical determinants in cytotoxic necrotizing factor (CNF) toxins driving Rho G-protein deamidation versus transglutamination

Autor: Nicholas B. Handy, Yiting Xu, Damee Moon, Jacob J. Sowizral, Eric Moon, Mengfei Ho, Brenda A. Wilson

Publikováno v: mBio, Vol 15, Iss 7 (2024)

ABSTRACT The cytotoxic necrotizing factor (CNF) family of AB-type bacterial protein toxins catalyze two types of modification on their Rho GTPase substrates: deamidation and transglutamination. It has been established that E. coli CNF1 and its close

Externí odkaz: https://doaj.org/article/0f54469769254026a3d75100382125eb

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Akademický článek

Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations

Autor: Ignacio de la Mora-de la Mora, Itzhel García-Torres, Luis Antonio Flores-López, Gabriel López-Velázquez, Gloria Hernández-Alcántara, Saúl Gómez-Manzo, Sergio Enríquez-Flores

Publikováno v: Molecules, Vol 29, Iss 21, p 5047 (2024)

Triosephosphate isomerase (TPI) dysfunction is a critical factor in diverse pathological conditions. Deficiencies in TPI lead to the accumulation of toxic methylglyoxal (MGO), which induces non-enzymatic post-translational modifications, thus comprom

Externí odkaz: https://doaj.org/article/af710411fdd9494393713ce2d7fc65e9

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Akademický článek

Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase

Autor: Larissa Dirr, Sven Cleeves, Isabel Ramón Roth, Linghui Li, Timm Fiebig, Thomas Ve, Susanne Häussler, Armin Braun, Mark von Itzstein, Jana I. Führing

Publikováno v: mBio, Vol 15, Iss 4 (2024)

ABSTRACTMultidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public hea

Externí odkaz: https://doaj.org/article/d8d00c4b95764f78a4b8670e9a0d7496

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Akademický článek

Unraveling the crystal structure of the HpaA adhesin: insights into cell adhesion function and epitope localization of a Helicobacter pylori vaccine candidate

Autor: Cyrielle Martini, Victoria Araba, Meriem Beniani, Paula Armoa Ortiz, Mimi Simmons, Mariem Chalbi, Abdelkader Mellouk, Majida El Bakkouri, Charles Calmettes

Publikováno v: mBio, Vol 15, Iss 3 (2024)

ABSTRACT Helicobacter pylori is a bacterium that exhibits strict host restriction to humans and non-human primates, and the bacterium is widely acknowledged as a significant etiological factor in the development of chronic gastritis, peptic ulcers, a

Externí odkaz: https://doaj.org/article/39537aff6626420ba731ee1d5ceb832a

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Akademický článek

Insights into virulence: structure classification of the Vibrio parahaemolyticus RIMD mobilome

Autor: Lisa N. Kinch, R. Dustin Schaeffer, Jing Zhang, Qian Cong, Kim Orth, Nick Grishin

Publikováno v: mSystems, Vol 8, Iss 6 (2023)

ABSTRACT Vibrio parahaemolyticus (Vpar) is a major cause of seafood-related gastroenteritis. A pandemic strain, RIMD2210633 (RIMD), has emerged from ancestors due to virulence mechanisms acquired through horizontal gene transfer (HGT). Mobile genetic

Externí odkaz: https://doaj.org/article/bffd9f8ec1e74b57ad8fc7455c22b703

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